DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and AP2A2

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001229766.1	Gene:	AP2A2 / 161	HGNCID:	562	Length:	940	Species:	Homo sapiens

Alignment Length:	904	Identity:	185/904 - (20%)
Similarity:	343/904 - (37%)	Gaps:	151/904 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LFQSKDVVLRRMVYLGIKEL-SSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQA 139
            |..|.....:::.||.|..| :|.:|.:.::.:::..|:..:...:...|:..:.|:....|.:|
Human    82 LLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEA 146

  Fly   140 VERYMKQCIV--DKNAAVSCAALVSSLRLANTAGDVVKR--WANEAQEALNSDNIMVQYHALGLL 200
            ....:.:.:|  |...:|..:|.:..|||..|:.|:|..  |.:.....||..::.|...|..|:
Human   147 FAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLI 211

  Fly   201 --------YHIRKSDRLAVSKLVNKLTRGS----------LKSPYAVCMLIRIACKLIEEEDIPS 247
                    ...:.|..||||:|...:|..|          :.:|:....|:|    |::....|.
Human   212 TTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLR----LLQCYPPPE 272

  Fly   248 EELSDSPLFTFIESCLRHKSE--------------MVIYEAAHAIVNLKNTNPRMLSPAFSILQL 298
            :......|...:|:.|....|              .|::||...|:: .::.|.:|..|.:.|..
Human   273 DPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIH-HDSEPNLLVRACNQLGQ 336

  Fly   299 FCSSPKATLRFAAVR---TLNKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESS 360
            |....:..||:.|:.   ||.....:|.|..|.....:..|.|:.:.||...|:..|......|:
Human   337 FLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSN 401

  Fly   361 VERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIV-DT 424
            ..:::.::.:::.......:..:|..:..|..||...:|..::.:..::|..|  :|.:..| ..
Human   402 APQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAG--DYVSEEVWYR 464

  Fly   425 IITIIEENADAKESGLSHLCEFIE--DCEHVSLAVRILHLLGKEGPFAA-----TPSKYIRFIYN 482
            :|.|:....|.:......:.|.::  .| |.:|.....::||:.|...|     :|......:::
Human   465 VIQIVINRDDVQGYAAKTVFEALQAPAC-HENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHS 528

  Fly   483 RVILESPIVRAAAVTAMAQFGASCPALLSNIL-VLLGRCQM-DPDDEVRDRATYYLSILNSERPE 545
            :..|.|...||..::...:|....|.:...|. ||....|: :.|.|::.||..||.:......:
Human   529 KFHLCSVPTRALLLSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTD 593

  Fly   546 LYKNYI------IERENCSLALLEK----SLVEHLNGDVDTRFDISI----------VPKAAIVK 590
            :....:      .|||:..||.|:|    |.|..|.   ||:.|.|:          ...:|:..
Human   594 ILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLE---DTKRDRSVDVNGGPEPAPASTSAVST 655

  Fly   591 PVIANDVMLVTSSAPRPPKITREEESAARLAQL--PGIQVLGPIHRSTAPIQLTESETEYTVQCI 653
            |..:.|::.:.::.|.|.........:..|..:  ....|:.|:    ||    .||..:.
Human   656 PSPSADLLGLGAAPPAPAGPPPSSGGSGLLVDVFSDSASVVAPL----AP----GSEDNFA---- 708

  Fly   654 KHIFGQHVVFQFDCLNTLSDQILENVRVELTLPEGFTT---RAVIPCPKLPYNDLQTTFVIVEFP 715
                      :|.|.|  :..:.||..:::.|...|..   |..|      :...:|:...:.|.
Human   709 ----------RFVCKN--NGVLFENQLLQIGLKSEFRQNLGRMFI------FYGNKTSTQFLNFT 755

  Fly   716 PDAANSIATFGATLRFVVKDCDPNT-GEPESEEGYDDEYMLEDLELTVAD--------------Q 765
            |....| ......|....|..||.. |..:.::..:.|.:.:..|..|.:              |
Human   756 PTLICS-DDLQPNLNLQTKPVDPTVEGGAQVQQVVNIECVSDFTEAPVLNIQFRYGGTFQNVSVQ 819

  Fly   766 IQKTRKNNFQVSWDAADS--EEWL-----QAEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENV 823
            :..|....||.:..|:..  :.|.     |.|...:..|...:...| |..||:|.|:|.|.|..
Human   820 LPITLNKFFQPTEMASQDFFQRWKQLSNPQQEVQNIFKAKHPMDTEV-TKAKIIGFGSALLEEVD 883

  Fly   824 PEGTH------LHTLLCSGTFRGGAEILVRAKL-ALSEGVTLNLTVRSTDQDVAELITA 875
            |...:      :||    .|.:.|..:.:...| |....:||..:..:..|.:.||::|
Human   884 PNPANFVGAGIIHT----KTTQIGCLLRLEPNLQAQMYRLTLRTSKEAVSQRLCELLSA 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	185/904 (20%)
		HEAT repeat	402..427	CDD:293787	4/25 (16%)
		HEAT repeat	439..465	CDD:293787	5/27 (19%)
		HEAT repeat	475..505	CDD:293787	5/29 (17%)
		HEAT repeat	512..538	CDD:293787	10/27 (37%)
		COP-gamma_platf	620..761	CDD:285908	27/146 (18%)
		Coatomer_g_Cpla	763..877	CDD:292991	31/141 (22%)
AP2A2	NP_001229766.1	Lipid-binding	5..80
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250\|UniProtKB:P18484	11..12
		Adaptin_N	29..591	CDD:279882	107/516 (21%)
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250\|UniProtKB:P18484	57..61
		Cnd1	<163..>235	CDD:289487	20/71 (28%)
		HEAT repeat	332..355	CDD:293787	5/22 (23%)
		HEAT repeat	369..398	CDD:293787	6/28 (21%)
		HEAT repeat	408..434	CDD:293787	2/25 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..682		16/71 (23%)
		Alpha_adaptinC2	718..821	CDD:197886	19/109 (17%)
		Alpha_adaptin_C	827..935	CDD:280460	26/112 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910