DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and AP2A1

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_011524858.1	Gene:	AP2A1 / 160	HGNCID:	561	Length:	994	Species:	Homo sapiens

Alignment Length:	952	Identity:	184/952 - (19%)
Similarity:	345/952 - (36%)	Gaps:	224/952 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LFQSKDVVLRRMVYLGIKEL-SSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQA 139
            |..|.....:::.||.|..| :|.:|.:.::.:::..|:..:...:...|:..:.::....|.:|
Human    99 LLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEA 163

  Fly   140 VERYMKQCIV--DKNAAVSCAALVSSLRLANTAGDVVK--RWANEAQEALNSDNIMVQYHALGLL 200
            ....:.:.:|  |...:|..:|.:..|||...:.|:|.  .|.......||..::.|...|:.|:
Human   164 FAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVVTAAVSLI 228

  Fly   201 YHIRKSD--------RLAVSKLVNKLTRGS----------LKSPYAVCMLIRIACKLIEEEDIPS 247
            ..:.|.:        .||||:|...::..|          :.:|:....|:|    |::....|.
Human   229 TCLCKKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLR----LLQCYPPPE 289

  Fly   248 EELSDSPLFTFIESCLRHKSE--------------MVIYEAAHAIVNLKNTNPRMLSPAFSILQL 298
            :......|...:|:.|....|              .:::|....|::. ::.|.:|..|.:.|..
Human   290 DAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHY-DSEPNLLVRACNQLGQ 353

  Fly   299 FCSSPKATLRFAAVR---TLNKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLL----KTG 356
            |....:..||:.|:.   ||.....:|.|..|..:..:..|.|:.:.||...|...|.    ::.
Human   354 FLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSN 418

  Fly   357 AESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSI 421
            |:..|..:::.:.|....|.:|    :|..:..|..||...::..::.:..::|..|  :|.:..
Human   419 AKQIVSEMLRYLETADYAIREE----IVLKVAILAEKYAVDYSWYVDTILNLIRIAG--DYVSEE 477

  Fly   422 V-DTIITIIEENADAKESGLSHLCEFIE--DCEHVSLAVRILHLLGKEGPFAA-----TPSKYIR 478
            | ..::.|:....|.:......:.|.::  .| |.::.....::||:.|...|     :|.....
Human   478 VWYRVLQIVTNRDDVQGYAAKTVFEALQAPAC-HENMVKVGGYILGEFGNLIAGDPRSSPPVQFS 541

  Fly   479 FIYNRVILESPIVRAAAVTAMAQFGASCPALLSNILVLL--GRCQMDPDDEVRDRATYYLSILNS 541
            .::::..|.|...||..::...:|....|...:.|..:|  |....:.|.|::.||..||::.:.
Human   542 LLHSKFHLCSVATRALLLSTYIKFINLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSV 606

  Fly   542 ERPELYKNYI------IERENCSLALLEK-------SLVEHLNGDVDTRFDIS--IVPKAAIVKP 591
            ...::....:      .|||:..||.|::       |.::....|..:. ||:  :.|..:.|..
Human   607 ASTDVLATVLEEMPPFPERESSILAKLKRKKGPGAGSALDDGRRDPSSN-DINGGMEPTPSTVST 670

  Fly   592 VIANDVMLVTSSAPRP-----------------------PKI--TREEESAARL----------- 620
            ...:..:|...:||.|                       |.:  |.||...:.|
Human   671 PSPSADLLGLRAAPPPAAPPASAGAGNLLVDVFDGPAAQPSLGPTPEEAFLSELEPPAPESPMAL 735

  Fly   621 ------AQLPGIQVLGPIHRSTAPIQLTESETEYTVQCIKHIFGQHVVFQFDCLNT---LSDQIL 676
                  |..||.:.:||      ||...:                .::.:|.|.|.   ..:|:|
Human   736 LADPAPAADPGPEDIGP------PIPEAD----------------ELLNKFVCKNNGVLFENQLL 778

  Fly   677 E-NVRVELTLPEG----------------FTTRAVIPCPKLPYNDLQTTFVI----VEFPPDAAN 720
            : .|:.|.....|                |:...|.|      .||||...:    |....|.
Human   779 QIGVKSEFRQNLGRMYLFYGNKTSVQFQNFSPTVVHP------GDLQTQLAVQTKRVAAQVDG-- 835

  Fly   721 SIATFGATLRFVVK-DC-----DPNTGEPESEEGYDDEYMLEDLELTVADQIQKTR--KNNFQVS 777
                 ||.::.|:. :|     .|.........|...:.:...|.:|:....|.|.  ..:|...
Human   836 -----GAQVQQVLNIECLRDFLTPPLLSVRFRYGGAPQALTLKLPVTINKFFQPTEMAAQDFFQR 895

  Fly   778 WDAADSEEWLQAEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENV---PEGTHLHTLLCSGTFR 839
            |....    |..::...:.......||..|..|:||.|:| |.:||   ||           .|.
Human   896 WKQLS----LPQQEAQKIFKANHPMDAEVTKAKLLGFGSA-LLDNVDPNPE-----------NFV 944

  Fly   840 GGAEILVRAKLALSEGVTL-----------NLTVRSTDQDVA 870
            |..  :::.| ||..|..|           .||:|::.:.|:
Human   945 GAG--IIQTK-ALQVGCLLRLEPNAQAQMYRLTLRTSKEPVS 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	184/952 (19%)
		HEAT repeat	402..427	CDD:293787	4/25 (16%)
		HEAT repeat	439..465	CDD:293787	4/27 (15%)
		HEAT repeat	475..505	CDD:293787	5/29 (17%)
		HEAT repeat	512..538	CDD:293787	9/27 (33%)
		COP-gamma_platf	620..761	CDD:285908	32/187 (17%)
		Coatomer_g_Cpla	763..877	CDD:292991	29/124 (23%)
AP2A1	XP_011524858.1	Adaptin_N	46..608	CDD:279882	102/520 (20%)
		HEAT repeat	349..372	CDD:293787	5/22 (23%)
		HEAT repeat	386..415	CDD:293787	6/28 (21%)
		HEAT repeat	425..451	CDD:293787	5/29 (17%)
		Alpha_adaptinC2	772..875	CDD:197886	20/115 (17%)
		Alpha_adaptin_C	881..989	CDD:280460	29/122 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910