DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and AgaP_AGAP001267

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_321886.5	Gene:	AgaP_AGAP001267 / 1281911	VectorBaseID:	AGAP001267	Length:	929	Species:	Anopheles gambiae

Alignment Length:	984	Identity:	188/984 - (19%)
Similarity:	359/984 - (36%)	Gaps:	274/984 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDV-IIVTSSLTKDMTGKEDLYRAAAI 125
            |.::.:..|..:....|:.::.|:::|||.:...:....|: |:..::..||......|.||.|:
Mosquito    43 VGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDTNPLIRALAV 107

  Fly   126 RALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVV--KRWANEAQEALNSD 188
            |.:..|..:.:.:.:...:::|:.|::..|...|.|...:|.:.:..:|  :.:.::.::.|:..
Mosquito   108 RTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLYDISSSMVEDQGFLDQLKDLLSDS 172

  Fly   189 NIMVQYHALGLLYHIRKS----------DRLAVSKL---VNKLTRGSLKSPYAVCMLIRIACKLI 240
            |.||..:|:..|..|.::          :.:.::||   :|:.|...     .|.:|..:|
Mosquito   173 NPMVVANAVAALSEINEASASGQPLVEMNSVTINKLLTALNECTEWG-----QVFILDSLA---- 228

  Fly   241 EEEDIPSEELSDSPLFTFIESCLRHKSEMVIYEAAHAIVNL------KNTNPRMLSPAFS--ILQ 297
              ...|.:|.....:...|...|.|.:..|:..|...::.|      .|....||:...:  ::.
Mosquito   229 --NYTPKDEREAQSICERITPRLAHANAAVVLSAIKVLMKLLEILAGDNDFCSMLTKKLAPPLVT 291

  Fly   298 LFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRS--VATLAITTLLKTGAESS 360
            |..|.|:  :::.|:|.:|.:....|..:   ..:::......|..  |....:..:::...:|:
Mosquito   292 LLSSEPE--VQYVALRNINLIVQKRPDIL---KHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSN 351

  Fly   361 VERLMKQISTFVAEISDEFKVVVVQAI--CALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVD 423
            :.:::.::..:..|:..:|....|:||  ||:..:...:..|  :.|..:::.:.....:.:||
Mosquito   352 IAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCV--STLLDLIQTKVNYVVQEAIV- 413

  Fly   424 TIITIIEENADAKESGLSHLCEFIEDCEHVSLAVRILHLLGKEGPFAATPSKYIRFIYNRVIL-- 486
            .|..|..:..:..||.:|.|||.::..:.......::.::|          :|...|.|...|
Mosquito   414 VIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIG----------EYAERIDNADELLD 468

  Fly   487 --------ESPIVRAAAVTAMAQFGASCPA----LLSNILVLLGRCQMDPDDEVRDRATYYLSIL 539
                    |:..|:...:||:.:.....||    |:.:||.|..:...:||  :|||...|..:|
Mosquito   469 GFLEGFQDENAQVQLQLLTAVVKLFLKRPADTQELVQHILSLATQDSDNPD--LRDRGFIYWRLL 531

  Fly   540 N-----------------SERPELYKNYIIERENCSLALL-------------------EKSL-- 566
            :                 ||..:|.:..:::...|.::.|                   .|||
Mosquito   532 STDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEGRGAGVRKSLPN 596

  Fly   567 ---------------------VEHLNGDVDTRFDISIVPKAAIVKPVIAN--------DVML--- 599
                                 .|.|.||: ...||......|...|..:|        |::|
Mosquito   597 RSASAAGEDSSSVQEATVIPNQESLIGDL-LSMDIGAPAAPAAPAPASSNVDLLGGGLDILLGGG 660

  Fly   600 ------VTSSAPRP---------------------------PKITREEESAARLAQLP-----GI 626
                  ...:||.|                           ||||          .||     |:
Mosquito   661 PVASNDAAPAAPAPAGGSAAGGLLGDIFGIGPVSSSNMIQIPKIT----------WLPADKGKGL 715

  Fly   627 QVLGPIHRSTAPIQL--------TESETEYTVQCIKHIFGQHVVFQFDCLNTLSDQILENVRVEL 683
            ::.|...|....:.:        .::.|.:.:|..|:.||   :.....|.....|..::|...|
Mosquito   716 EIQGTFSRRAGQVYMDMTFTNKAMQAMTGFAIQLNKNSFG---LVPSAPLQVAPLQPSQSVDTSL 777

  Fly   684 TLPEGFTTRAVIPCPKL-PYNDLQTTFVIVEFPPDAANSIATF-------GATLRFVVKDCDPNT 740
            .|  |.|.    |..:: |.|:||...         .|::..|       |..| ||
Mosquito   778 AL--GTTG----PVQRMEPLNNLQVAI---------KNNVDIFYFACLVHGNVL-FV-------- 818

  Fly   741 GEPESEEGYDDE--YMLEDLELTVADQIQKTRKNNFQVSWDAADSEEWLQAEDTFVLSAVTTLQD 803
                 |:|..|:  ::....|:..|::||    .|.......||:          |.:.:|.  :
Mosquito   819 -----EDGQLDKRVFLTTWKEIPAANEIQ----YNLHGIVGTADT----------VAAKMTA--N 862

  Fly   804 AVNTIVKILGLGAANLSENVPEGTHLHTLLCSGTFRGGAEILVRAKLAL-SEGVTLNLTVRSTDQ 867
            ::.||.|          .|| ||..:  |..|........:|:..||:. |...||:|..||.
Mosquito   863 SIFTIAK----------RNV-EGQDM--LYQSLKLTNNIWVLLELKLSPGSSDATLSLKTRSV-- 912

  Fly   868 DVAELITAA 876
            :|..:|.||
Mosquito   913 EVGAIIFAA 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	188/984 (19%)
		HEAT repeat	402..427	CDD:293787	4/24 (17%)
		HEAT repeat	439..465	CDD:293787	4/25 (16%)
		HEAT repeat	475..505	CDD:293787	8/39 (21%)
		HEAT repeat	512..538	CDD:293787	9/25 (36%)
		COP-gamma_platf	620..761	CDD:285908	32/163 (20%)
		Coatomer_g_Cpla	763..877	CDD:292991	30/115 (26%)
AgaP_AGAP001267	XP_321886.5	Adaptin_N	38..535	CDD:279882	100/522 (19%)
		HEAT repeat	51..75	CDD:293787	6/23 (26%)
		HEAT repeat	87..114	CDD:293787	7/26 (27%)
		Cnd1	99..269	CDD:289487	35/180 (19%)
		HEAT repeat	121..151	CDD:293787	6/29 (21%)
		HEAT repeat	160..186	CDD:293787	6/25 (24%)
		HEAT repeat	197..229	CDD:293787	7/42 (17%)
		HEAT repeat	393..417	CDD:293787	5/26 (19%)
		HEAT repeat	429..458	CDD:293787	6/38 (16%)
		HEAT repeat	465..495	CDD:293787	5/29 (17%)
		HEAT repeat	506..542	CDD:293787	10/37 (27%)
		Alpha_adaptinC2	709..807	CDD:197886	22/115 (19%)
		B2-adapt-app_C	817..927	CDD:198088	36/149 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910