DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and AgaP_AGAP000161

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_310978.5	Gene:	AgaP_AGAP000161 / 1272102	VectorBaseID:	AGAP000161	Length:	1058	Species:	Anopheles gambiae

Alignment Length:	706	Identity:	138/706 - (19%)
Similarity:	264/706 - (37%)	Gaps:	180/706 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RREKDDEEDGPSNAYQNLEKTSVLQETRTFNETPVNPRKCIHILTKILYLINQGEQLVAREATDC 69
            |..||:|....:...:.::     ||.|..|.:..:     :.:.|:.||     |:...:.:..
Mosquito    26 RNNKDNEAKYIAQCIEEIK-----QELRQDNVSVKS-----NAVAKLTYL-----QMCGYDISWA 75

  Fly    70 FFAMTKLFQSKDVVLRRMVYLGIKE-LSSIAEDVIIVTSSLTKDMTGKEDLYRAAAIRAL-CSIT 132
            .|.:.::..|.....:|:.||...: ....:|.:::.|:.:.||::.........|:..| |.|:
Mosquito    76 GFNIIEVMSSNRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLSSTNQYDAGVALSGLSCFIS 140

  Fly   133 DN----------TMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNS 187
            .:          |::.:.:.|::.           .|::...::.....:.::....:.:|.|..
Mosquito   141 TDLSRDLANDIMTLMSSTKPYLRM-----------KAVLMMYKVFLRYPEALRPAFPKLKEKLED 194

  Fly   188 DNIMVQYHALGLLYHI-RKSDR--LAVSKLVNKLTRGSLKSPYAVCMLI--------------RI 235
            .:..||..|:.::..: ||:.:  |:::.:..||...|..:    .|||              |:
Mosquito   195 PDPSVQSAAVNVICELARKNPKNYLSLAPIFFKLMTTSTNN----WMLIKIIKLFGALTPLEPRL 255

  Fly   236 ACKLIEEEDIPSEELSDSPLFTFIESCLRHKSEMVIYEAAHAIVN-LKNTNPRMLSPAFSI---- 295
            ..||||            ||...|...:...:..::||..:.::. |.:.:..|.:.:.||
Mosquito   256 GKKLIE------------PLTNLIHRQVVTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCV 308

  Fly   296 --LQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLL----K 354
              |::........|::..:..::|:..|||.:|.|....:...:.|.:.|:...|:..|.    |
Mosquito   309 QKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQTHKDLILACLDDKDESIRLRALDLLYGMVSK 373

  Fly   355 TGAESSVERLMKQISTFVAEIS---DEFKVVVVQAICA-----LCTKYPRKHTVLMNFLSGMLRE 411
            ......|.||:..:..  ||.|   ||....|:: ||:     ..|.:....|||:..:   |.|
Mosquito   374 KNLMEIVRRLLGHMER--AEGSSYRDELLYKVIE-ICSQGSYQYVTNFEWYLTVLVELI---LLE 432

  Fly   412 EGGLE-----------------YKTSIVDTIITIIE-------ENADAKESGLSHLCEFI--EDC 450
            .|...                 .:|..|:.:.|::|       .|...:|  :.:...:|  |..
Mosquito   433 SGSRHGRLIAGQLLDVAIRVQAVRTFAVNEMATLLETYPVTAAPNGTMQE--VLYAAAWIVGEFA 495

  Fly   451 EHVSLAVRILHLLGKEGPFAATPSKYIRFIY--NRVILESPIVRAAAVTAMAQFGAS----CPAL 509
            .|:....|.|.:|.:..|.|.    :|:.:|  |.:.|.:.:|..|   ...:.||:    |..|
Mosquito   496 PHLDGPERTLAVLLQPKPVAG----HIQAVYVQNALKLFAHLVGEA---VRQRDGAAIERHCQTL 553

  Fly   510 LSNILVLLGRCQMDPDDEVRDRAT--YYLSILNSERPELYKNYIIERENCSLALLEKSLVEHLNG 572
            ...:...|.    ..|.||::||:  |:|.:|                          |.|.|.|
Mosquito   554 AEGLRSYLS----SADIEVQERASSVYFLVVL--------------------------LRESLGG 588

  Fly   573 DVDTRFDISIVPKAAIVK--PVIANDVMLVTSSAPRP--PKITREEESAARLAQLP 624
            ..:.:...:.|....:::  |.||.|:..:.:|...|  ||       |.|..|||
Mosquito   589 GANQQHAAAPVADGGLLELTPDIATDLQGLFASELNPVAPK-------AQRKVQLP 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	135/700 (19%)
		HEAT repeat	402..427	CDD:293787	5/41 (12%)
		HEAT repeat	439..465	CDD:293787	6/27 (22%)
		HEAT repeat	475..505	CDD:293787	7/31 (23%)
		HEAT repeat	512..538	CDD:293787	8/27 (30%)
		COP-gamma_platf	620..761	CDD:285908	3/5 (60%)
		Coatomer_g_Cpla	763..877	CDD:292991
AgaP_AGAP000161	XP_310978.5	Adaptin_N	32..572	CDD:279882	112/600 (19%)
		HEAT repeat	151..172	CDD:293787	3/31 (10%)
		HEAT repeat	184..212	CDD:293787	5/27 (19%)
		Cnd1	<192..265	CDD:289487	20/88 (23%)
		HEAT repeat	220..258	CDD:293787	7/41 (17%)
		HEAT repeat	270..295	CDD:293787	3/24 (13%)
		HEAT repeat	304..333	CDD:293787	3/28 (11%)
		BLVR	696..855	CDD:283923
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910