DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gammaCOP and AP2A_ANOGA

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_310153.4	Gene:	AP2A_ANOGA / 1271372	VectorBaseID:	AGAP009538	Length:	934	Species:	Anopheles gambiae

Alignment Length:	898	Identity:	187/898 - (20%)
Similarity:	353/898 - (39%)	Gaps:	148/898 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LFQSKDVVLRRMVYLGIKELSSIAEDVI-IVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQA 139
            |..|.....:::.||.|..|.:...|:| ::..|:..|:..:..::...|::.:.:|....|.:|
Mosquito    81 LLSSNKYSEKQIGYLFISVLVNTNSDLIKLIIQSIKNDLQSRNPIHVNLALQCIANIGSQDMAEA 145

  Fly   140 VERYMKQCIV--DKNAAVSCAALVSSLRLANTAGDVVK--RWANEAQEALNSDNIMVQYHALGLL 200
            ....:.:.:|  |....|..:|.:..|||..|..|::.  .|.:.....||..::.|...|..|:
Mosquito   146 FSNEIPKLLVSGDTMDVVKQSAALCLLRLFRTCPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLI 210

  Fly   201 YHIRKSD--------RLAVSKLVNKLTRG----------SLKSPYAVCMLIRIACKLIEEEDIPS 247
            ..:.|.:        .||||:|...:|..          .:.:|:....|:|    |::..:.|:
Mosquito   211 DALVKKNPEEYKGCVSLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLR----LLQNYNPPT 271

  Fly   248 EELSDSPLFTFIESCL----------------RHKS--EMVIYEAAHAIVNLKNTNPRMLSPAFS 294
            |   |..:...:..||                :|.:  ..|::||.:.|:: .::.|.:|..|.:
Mosquito   272 E---DPGVRGRLNECLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIH-NDSEPSLLVRACN 332

  Fly   295 ILQLFCSSPKATLRFAAVRTLNKVA---MTHPAAVTTCNLDLEGLITDSNRSVATLAITTLL--- 353
            .|..|.|:.:..||:.|:.::..:|   .:|.|......:.:..:..:.:.||...|:..|.
Mosquito   333 QLGQFLSNRETNLRYLALESMCHLATSEFSHEAVKKHQEVVILSMKMEKDVSVRQQAVDLLYAMC 397

  Fly   354 -KTGAESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEY 417
             ::.||..|:.::..:.|....|.:|    :|..:..|..||...:|..::.:..::|..|  :|
Mosquito   398 DRSNAEEIVQEMLNYLETADYSIREE----MVLKVAILAEKYATDYTWYVDVILNLIRIAG--DY 456

  Fly   418 KTSIV-DTIITIIEENADAKESGLSHLCEFIE--DCEHVSLAVRILHLLGKEGPFAA-----TPS 474
            .:..| ..:|.|:....:.:......:.|.::  .| |.::.....::||:.|...|     .|.
Mosquito   457 VSEEVWYRVIQIVINREEVQGYAAKTVFEALQAPAC-HENMVKVGGYILGEFGNLIAGDSRSAPM 520

  Fly   475 KYIRFIYNRVILESPIVRAAAVTAMAQFGASCPALLSNILVLLGRCQ--MDPDDEVRDRATYY-- 535
            ...:.::::..|.|.:.||..::...:|....|.:...|..:..:..  ...|.|::.||:.|
Mosquito   521 VQFKLLHSKYHLCSSMTRALLLSTYIKFINLFPEIRGTIQDVFRQHSNLRSADAELQQRASEYLQ 585

  Fly   536 LSILNS---------ERPELYKNYIIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAAIVKP 591
            |||:.|         |.|.     ..|||:..||:|:|.....:..:.:.|...|.||.:.  ..
Mosquito   586 LSIVASTDVLATVLEEMPS-----FPERESSILAVLKKKKPGRVPENAEIRETKSPVPNSH--NN 643

  Fly   592 VIANDVMLVTSSA------------PRPPKITREEESAARLAQLPGIQVLGPIHRSTAPIQLTES 644
            ..:|.....||||            ..||        |::...|  |.|||.|: |||     ..
Mosquito   644 AHSNAQTNHTSSANNANASSDLLGLSTPP--------ASQSGTL--IDVLGDIY-STA-----NG 692

  Fly   645 ETEYTVQCIKHIFGQH-VVFQFDCLNT-LSDQILENVRVELTLPEGFTTRAVIP--CPKLPYNDL 705
            .:.......|.:|..: |:|:.|.|.. :..:..:|:. .|.|..|..|:..:.  .|.|.::..
Mosquito   693 NSNVVNNSKKFVFKNNGVLFENDLLQIGVKSEFRQNLG-RLGLYYGNKTQTALQNFVPTLQWSAE 756

  Fly   706 QTTFVIVEFPPDAANSIATFGATL-RFVVKDC-DPNTGEPE-----SEEGYDDEYMLEDLELTVA 763
            ....:.|:.  .|.......||.: :.:..:| |...|.|.     ...|...:.:..:|.||:.
Mosquito   757 DALKLNVQI--KAVEPTLEAGAQIQQLLTAECIDHYLGAPSIVISFRVSGGAPQKITVNLPLTIN 819

  Fly   764 DQIQKTRKN--NFQVSWDAADSEEWLQAEDTFVLSAVTTLQDAVNTIVKILGLGAANLSENVPEG 826
            ...:.|..|  :|...|.....|: .:|:..|.......|..|.|   |:.|.|...|....|..
Mosquito   820 KFFEPTEMNAESFFARWRNLGGEQ-QRAQRVFKAQQPLDLPGARN---KLTGFGMQLLDSIDPNP 880

  Fly   827 THLHTLLCSGTFRGGAE---ILVRA---KLALSEGVTLNLTVRSTDQDVAELI 873
            .:   ::|:|.....|.   .|:|.   |.|....:|:..::.:..|::.:|:
Mosquito   881 DN---MVCAGIIHTQAHKVGCLLRLEPNKQAQMFRLTIRSSLEAVTQEICDLL 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	187/898 (21%)
		HEAT repeat	402..427	CDD:293787	4/25 (16%)
		HEAT repeat	439..465	CDD:293787	4/27 (15%)
		HEAT repeat	475..505	CDD:293787	5/29 (17%)
		HEAT repeat	512..538	CDD:293787	7/29 (24%)
		COP-gamma_platf	620..761	CDD:285908	32/151 (21%)
		Coatomer_g_Cpla	763..877	CDD:292991	25/119 (21%)
AP2A_ANOGA	XP_310153.4	Adaptin_N	28..586	CDD:279882	103/519 (20%)
		Alpha_adaptinC2	711..815	CDD:197886	19/106 (18%)
		Alpha_adaptin_C	821..929	CDD:280460	24/114 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910