DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and Ap1g2

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_031481.2	Gene:	Ap1g2 / 11766	MGIID:	1328307	Length:	791	Species:	Mus musculus

Alignment Length:	684	Identity:	128/684 - (18%)
Similarity:	259/684 - (37%)	Gaps:	157/684 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NLEKTSVLQETR----TFNETPVNPRKCIHI---------------LTKILYLINQGEQLVAREA 66
            :|....:::|.|    ...|..|..::|..|               |.|:||:     .::...|
Mouse     5 SLRLQDLIEEIRGAKTQAQEREVIQKECAQIRASFRDGDPLQRHRQLAKLLYV-----HMLGYPA 64

  Fly    67 ----TDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDV-IIVTSSLTKDMTGKEDLYRAAAIR 126
                .:|.    ||..|.....:|:.|||...|.....|. :::|:|:..|::......:..|:.
Mouse    65 HFGQMECL----KLIASPRFTDKRVGYLGAMLLLDERHDSHLLITNSIKNDLSQGNQPVQGLALC 125

  Fly   127 ALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIM 191
            .|.::....|.:.:...:::.::..:..|...|:::::.:.....::...:.....:.|...:..
Mouse   126 TLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKDPELSGIFLPPCTKLLRERHHG 190

  Fly   192 VQYHALGL-----------LYHIRKSDRLAVSKLVNKLTRG--------SLKSPYAVCMLIRIAC 237
            :|...:.|           |.|.||.....|..|...:|.|        .:..|:....::|:..
Mouse   191 IQLGTVTLITELCERNPAALRHFRKVVPQLVQILRTLVTTGYSTEHSISGVSDPFLQVQILRLLR 255

  Fly   238 KLIEEEDIPSEELSD--SPLFTFIESCLRHKSEMVIYE------AAHAIVNLKNTNPRMLSPAFS 294
            .|....:..||.::|  :.:.|..::. |:....|:.|      |.|:...|     |:|  |.:
Mouse   256 ILGRNHEESSETMNDLLAQVATNTDTS-RNAGNAVLLETVLTIMAIHSAAGL-----RVL--AVN 312

  Fly   295 ILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAES 359
            ||..|..:....:|:.|:.:|.::..:..:||......:...:.:::.|::..|:...|.....|
Mouse   313 ILGRFLLNNDKNIRYVALTSLLQLVQSDHSAVQRHRSTVVECLQETDASLSRRALELSLALVNSS 377

  Fly   360 SVERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSG-MLREEGGLEYKTSIVD 423
            :|..:|:::..|:.....:     ::|.||                || :|..|.....|...:|
Mouse   378 NVRAMMQELQAFLESCPPD-----LRADCA----------------SGILLAAERFAPSKRWHID 421

  Fly   424 TIITII-EENADAKESGLSHLCEFIEDCEHV-SLAVRILH------------------LLGKEG- 467
            ||:.:: ...|..::..:::|.:.|.:.|.: :.:||.|:                  .:|:.|
Mouse   422 TILHVLTTAGAHVRDDAVANLTQLIGEAEELHTYSVRRLYSALAEDISQQPLVQVAAWCIGEYGD 486

  Fly   468 -----------PFAATPSKYIRFIYNRVILES----PIVRAAAVTAMAQFGASCPA---LLSNIL 514
                       ||.......:..:  ..:|:|    |..|..|:||:.:.......   .:..::
Mouse   487 LLLEGNCEETEPFQVEEEDVLALL--EKVLQSHMSLPATRGYAITALMKLSTRLRGDNNRIRQVV 549

  Fly   515 VLLGRCQMDPDDEVRDRATYYLSILNSERPELYKNYIIERENCSLALLEK-SLVEHLNGDVDTRF 578
            .:.|.|   .|.|::.||..|.:        |::.|    ::...|:||| .|||  .||..
Mouse   550 SIYGSC---VDLELQQRAVEYNT--------LFQKY----DHMRAAILEKMPLVE--RGDPH--- 594

  Fly   579 DISIVPKAAIVKPVIANDVMLVTSSAPRPPKITR 612
                |.:....|...|.. :.||:.||..|:.|:
Mouse   595 ----VKEGGKEKQTEAQP-LEVTAPAPTEPQATK 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	128/684 (19%)
		HEAT repeat	402..427	CDD:293787	8/25 (32%)
		HEAT repeat	439..465	CDD:293787	6/44 (14%)
		HEAT repeat	475..505	CDD:293787	7/33 (21%)
		HEAT repeat	512..538	CDD:293787	7/25 (28%)
		COP-gamma_platf	620..761	CDD:285908
		Coatomer_g_Cpla	763..877	CDD:292991
Ap1g2	NP_031481.2	Adaptin_N	24..575	CDD:279882	107/605 (18%)
Ap1g2	NP_031481.2	Alpha_adaptinC2	678..786	CDD:197886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910