DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gammaCOP and ap4b1

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_002932178.2	Gene:	ap4b1 / 100495149	XenbaseID:	XB-GENE-949306	Length:	724	Species:	Xenopus tropicalis

Alignment Length:	627	Identity:	125/627 - (19%)
Similarity:	246/627 - (39%)	Gaps:	103/627 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RKCIHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDV-IIV 105
            |..||   |::..:.||.     :.:..|..|.|...:.|:|.:::|||.:...:....|: ::.
Frog    30 RNVIH---KVIRHMTQGV-----DVSSVFMEMVKASATVDIVQKKLVYLYMCTYACQKPDLALLA 86

  Fly   106 TSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTA 170
            .::|.||.:....:.|..|:|::|::....:::.:::.:...:.||.:.|...|::...::.:..
Frog    87 INTLCKDCSDPNPMVRGLALRSMCNLRMPGIIEYIQQPIHNGLRDKASYVRRVAVLGCSKMHSQQ 151

  Fly   171 GDVVKRW--ANEAQEALNSDNIMVQYHALGLLYHIRKSDRLAVSKLVNKLTRGSLKSPYAVCMLI 233
            |||....  .||....|...:.:|..:.|..|..|.|.:...|   :||        |.|..:|.
Frog   152 GDVEVDGVVVNELYSLLRDPDPIVVVNCLRALEEILKGEGGVV---INK--------PIAHHLLN 205

  Fly   234 RIA-----------CKLIEEEDIPSEELSDSPLFTFIESCLRHKSEMVIYEAAHAI----VNLKN 283
            |:|           ..|:.......:||.|  :...:::.|:.....|:..|....    |...|
Frog   206 RMAELDQWGQSEVLGFLLRYNPKTEDELFD--ILNLLDNFLKSNHTSVVMGATKLFLVLAVEFPN 268

  Fly   284 TNPRMLSPAFSILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTT------CNLDLEGLITDSNR 342
            ....:|......|....:|....:.|||:..:.::..:.|...::      |:.:....|.....
Frog   269 VQRDVLGRLKGPLLAASASESKEMCFAALCHVREILRSMPGHFSSHYKKFFCSYNDPHYIKSQKM 333

  Fly   343 SVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFKVVVVQAICALCTKYPRKHTVLMNFLSG 407
            .:       |.:...:.:|..:::::.....:||.:.....:.||..:...:..|   .:..||.
Frog   334 DI-------LCELVNDENVHNVLEELRICCTDISVQLAQTAIFAIGRIAKTFSEK---CVKILSQ 388

  Fly   408 MLREEGGLEYKTSIVDTIITIIEENADAKESGLSHLCEFIEDCEHV---SLAVR-ILHLLGKEGP 468
            :|  |...|:.||   .:|....:........::.:|..:..||.:   :...| ::.|||..|.
Frog   389 LL--EFNQEHITS---AVIQTFRDLVWLCPQCIAKVCLALPGCEEIIQDNEGKRALIWLLGMHGD 448

  Fly   469 FAATPSKYI--RFIYNRVILESPIVRAAAVTAMAQFGASCPALLSNILVLLGR----C-QMDPDD 526
            ..:. :.||  .|:.|.....||.|:...:||:.:...|.||...:   :|||    | :.:.|.
Frog   449 VISN-APYILEDFVDNIKTEISPTVKIELLTAVVRLFLSRPAECQD---MLGRLIYYCIEEEIDM 509

  Fly   527 EVRDRATYYLSILNSERPELYKNYIIERENCSLALLEKSLVEHLN-------------------- 571
            .||||..:|..:|.|...|..:.....:.:.:|::||....:.:|
Frog   510 AVRDRGLFYYRLLASGVNEAKQVMNSPKSDPTLSVLENQTDQPINTWVPAFNTLMPLHDIKHGLA 574

  Fly   572 ------GDVDTRFDISIVPKAAIVKPVIANDVMLVTSSAPRP 607
                  ||.....:|::  ||.:..|:.|.|:.|.::....|
Frog   575 LTAGSEGDHHVSEEINL--KADLGNPLDAADLTLESNITMTP 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	125/627 (20%)
		HEAT repeat	402..427	CDD:293787	7/24 (29%)
		HEAT repeat	439..465	CDD:293787	6/29 (21%)
		HEAT repeat	475..505	CDD:293787	9/31 (29%)
		HEAT repeat	512..538	CDD:293787	10/30 (33%)
		COP-gamma_platf	620..761	CDD:285908
		Coatomer_g_Cpla	763..877	CDD:292991
ap4b1	XP_002932178.2	Adaptin_N	11..522	CDD:366724	108/531 (20%)
		HEAT repeat	86..113	CDD:293787	7/26 (27%)
		HEAT repeat	120..150	CDD:293787	4/29 (14%)
		HEAT repeat	159..185	CDD:293787	6/25 (24%)
		B2-adapt-app_C	612..716	CDD:370272	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910