DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gammaCOP and ap1g2

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_012817266.2	Gene:	ap1g2 / 100124756	XenbaseID:	XB-GENE-995680	Length:	787	Species:	Xenopus tropicalis

Alignment Length:	787	Identity:	145/787 - (18%)
Similarity:	282/787 - (35%)	Gaps:	188/787 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EKTSVLQETRTFN-ETPVNPRKCIHI---------------LTKILYLINQGEQLVAREA----T 67
            |....::..:|.| |..|..|:|..|               |.|:||:     .::...|    .
Frog     9 ELIRAIRSVKTQNEEREVIQRECADIRSSFRDEDSLYRGRSLAKLLYV-----HMLGYPAHFGQM 68

  Fly    68 DCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDV-IIVTSSLTKDMTGKEDLYRAAAIRALCSI 131
            :|.    ||..|.....:|:.|||...|....:|. :::|:|:.:|:.....:.:..|:..|..:
Frog    69 ECL----KLIASSKFTDKRIGYLGAMMLLDERQDAHLLITNSMKRDLEHSSPVVQGLALCTLACL 129

  Fly   132 TDNTMLQAVERYMKQCIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHA 196
            ....|.:.:...::..:.:....|...|::.::.:.....::|:.:...::|.|......|.|.|
Frog   130 GSTEMCRDLAGEVEHLLQNSTGHVKKKAVLCAVHIIRKVPELVEMFVPVSEELLGEKRHGVLYGA 194

  Fly   197 LGLLYHI-------RKSDRLAVSKLVNKLTR-----------GSLKSPYAVCMLIRIACKLIEEE 243
            :.|:..|       .|..|..:..|:.||.:           ..:..|:....|:|: .|::.:.
Frog   195 VLLVTEICRRQPEACKRFRKLLPLLLQKLRQVMSGYSPDHVVSGVTDPFLQVRLLRL-LKILGQN 258

  Fly   244 DIPSEELSD--SPLFTFIESCLRHKS---EMVIYEAAHAIVNLKNTNP-RMLSPAFSILQLFCSS 302
            |   |.:.|  |.|...:.:|...:|   ..|:||....||:.|:.:. |:|  |.:||..|..|
Frog   259 D---ESVCDAMSDLLAQVSTCTDTQSNAGNSVLYETVLTIVDTKSASGLRVL--AVNILGRFLLS 318

  Fly   303 PKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQ 367
            ....:|:.|:.:||::..:..|||......:...:..::.|:...|:........|:::..:||:
Frog   319 SDKNIRYVALTSLNRLVQSDYAAVQRHRGTIVECLRQTDTSLNKKALELCFALVNETNILPMMKE 383

  Fly   368 ISTFVAEISDEFKVVVVQAICALCTKY---PRKHTVLMNFLSGMLREEGGLEYKTSIVDTII-TI 428
            :..|:.....|.|......|.....::   .|.|                       :|||: |:
Frog   384 LQRFLQTCPLELKQQCTSGIFLCAERFSPSTRWH-----------------------IDTIMGTL 425

  Fly   429 IEENADAKESGLSHLCEFIEDCE--HVSLAVRILHLLGK-------------------------- 465
            :......::..:|||...|....  |..:..|:...:.|
Frog   426 VTAGESVRDDAVSHLIHLISGASELHGYIVHRLFLAVSKDIGQQPLVQVAAWCIGEYGELLISGS 490

  Fly   466 -EGPFAATPSKYIRFIYNRVILES----PIVRAAAVTAMAQFG---ASCPALLSNILVLLGRCQM 522
             |.|...|....:..:..  ||:|    |..||..:||:.:..   ..|...:..::.:...|.
Frog   491 SEEPVKVTEDDVLDVLEG--ILQSHISLPNTRAYTLTAIMKLSTRFTRCVDRIRRVVSIYSSCH- 552

  Fly   523 DPDDEVRDRATYYLSILNSERPELYKNYIIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAA 587
              |.|::.||..|.:        |:|.|    ::...|:|||..:...:...:....|..:.:|.
Frog   553 --DVELQQRAVEYNA--------LFKKY----DHMRSAILEKMPLSEKSATEENETAIPELSEAT 603

  Fly   588 IVKPV----------------------IANDVMLVTSSAPRPPKITREEESAARLAQLPGIQVLG 630
            ...|:                      ::.|:.:.|||...|| :.:...|.:.|..|    :..
Frog   604 ERSPLDNSQINFAQPESQVTDLLGLLEVSTDMTMNTSSTAGPP-LPQNVTSGSSLLDL----LDE 663

  Fly   631 PIHRSTAPIQLTESETEYTVQCIKHIFGQHVVFQF------DCLNTLSDQILENVRVELTLPEGF 689
            |::....|:.:...:            |..|.|.|      ..|..::.....:..:.:|   .|
Frog   664 PVNHEMPPLVVYSKD------------GLQVEFSFMRPPSNPALLVITSSATNSSSITIT---DF 713

  Fly   690 TTRAVIP 696
            ..:|.:|
Frog   714 QLQAAVP 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	145/787 (18%)
		HEAT repeat	402..427	CDD:293787	3/25 (12%)
		HEAT repeat	439..465	CDD:293787	6/27 (22%)
		HEAT repeat	475..505	CDD:293787	8/36 (22%)
		HEAT repeat	512..538	CDD:293787	6/25 (24%)
		COP-gamma_platf	620..761	CDD:285908	13/83 (16%)
		Coatomer_g_Cpla	763..877	CDD:292991
ap1g2	XP_012817266.2	Adaptin_N	23..571	CDD:396262	115/602 (19%)
ap1g2	XP_012817266.2	Alpha_adaptinC2	674..782	CDD:197886	9/62 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910