DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gammaCOP and ap1g2

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001276787.1	Gene:	ap1g2 / 100007877	ZFINID:	ZDB-GENE-030616-587	Length:	794	Species:	Danio rerio

Alignment Length:	812	Identity:	164/812 - (20%)
Similarity:	319/812 - (39%)	Gaps:	149/812 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EKTSVLQ----ETRT-FNETPVNPRKCIHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDV 82
            |:..::|    |.|. |.:|....|.  |.|.|:||:     .::...|........:|..|...
Zfish    22 EERGIIQKECAEIRAQFRQTDNGERS--HSLAKLLYV-----HMLGYPAHFGQMECVRLIASPRY 79

  Fly    83 VLRRMVYLGIKELSSIAEDV-IIVTSSLTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQ 146
            ..:|:.|||...|....:|. :::|:|:..|::......::.|:..|..:..:.|.:.:...:::
Zfish    80 SEKRIGYLGAMMLLDEKQDASLLITNSIKNDLSHSSQYVQSLALCTLACMGSSEMCRDLAPEIER 144

  Fly   147 CIVDKNAAVSCAALVSSLRLANTAGDVVKRWANEAQEALNSDNIMVQYHALGLLYHI--RKSD-- 207
            .:....:.:...|.:.::.:.....::.:.:...|:..|:..|..|.:.|:.|:..:  |.::
Zfish   145 LLRASTSYIKKKATLCAVHIIRKVPELAELFTPSARSLLSEKNHGVLHGAVVLITELCERNAETL 209

  Fly   208 ---RLAVSKLVNKLTRGSLKSPYA----------------VCMLIRIACKLIEEEDIPSEELSD- 252
               |.||.:||. :.:|.:.|.|:                :..|:||   |....|..|:.::|
Zfish   210 DKFRKAVPELVT-IMKGLVTSSYSPEHNVAGISDPFLQVRILRLLRI---LGHNNDSASDAMNDL 270

  Fly   253 -SPLFTFIESCLRHKSEMVIYEAAHAIVNLKNTNPRMLSPAFSILQLFCSSPKATLRFAAVRTLN 316
             :.:.|..:|. :.....|:||....|::: |:...:...|.:||..|..:....:|:.::.:|.
Zfish   271 LAQVATNTDSS-KTAGSAVLYETVLTIMDI-NSESGLRVLAVNILGRFLLNNDRNIRYISMTSLQ 333

  Fly   317 KVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISDEFKV 381
            |:..|...||......:...:.|.:.||...|:...|...:..::..:||::..|::....|.:.
Zfish   334 KIVQTDHNAVQRHRGTIVDCLKDQDTSVKRRALELSLALVSPVNIRSMMKELLIFLSSCPVELRS 398

  Fly   382 VVVQAICALCTKY-PRKHTVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENADAKESGLSHLCE 445
            .....|.....:| |.|...:...|. :|...|| :.:...|..:|.:|...::.....:..|..
Zfish   399 QTASGIFNAAERYSPSKRWHIDTILH-VLTTAGG-DVRDETVPNLIQLITTASELHCYTVHKLYR 461

  Fly   446 -FIEDCEHVSLAVRILHLLGKEG------------PFAATPSKYIRFIYNRVILES----PIVRA 493
             .::|....||.......:|:.|            |...|....:..:  ..:|:|    |..|.
Zfish   462 ALVKDISQQSLVQVACWCIGEYGDLLLKGECEEIEPVQVTEDDVLDAL--ETVLQSHMSAPATRG 524

  Fly   494 AAVTAMAQFGASCP---ALLSNILVLLGRCQMDPDDEVRDRATYYLSILNSERPELYKNY----- 550
            .|:||..:......   ..:.:|:.:.|.|   .|.|::.||..|.:        |:|.|
Zfish   525 FALTATMKLSTRITDNVDRIRSIVSIYGSC---IDLELQQRAVEYNA--------LFKKYDHMRA 578

  Fly   551 -IIERENCSLALLEKSLVEHLNGDVDTRFDISIVPKAAIVKPVI----AN------DVMLVTSSA 604
             ::||    :.|:||:...|.|||...........|...|:|::    ||      |::..|.:.
Zfish   579 AVLER----MPLMEKNSPGHTNGDSSGEIKEPEPAKTKPVEPILLSEPANQVCDLLDLLGGTDTP 639

  Fly   605 PRP---PKITREEESAARLAQLPGIQVLGPIHRSTAP-------------IQL-TESETEYTVQC 652
            .:|   |..|....|:|.|     :.:||.:..:..|             ||. ::::|:.||..
Zfish   640 VQPSSAPTSTATTTSSADL-----LDLLGGLEPTPVPAVTVYEKNGVSLKIQCDSQTDTDITVTL 699

  Fly   653 IKHIFGQHVVFQFDCLNTLSDQILENVRVELTLPEG----------FTTRAVIPCP--------- 698
            |.....|:.:..|    ||...:.::|::::..|.|          .|...::..|
Zfish   700 IASNSTQNDISNF----TLQAAVPKSVQLQMKAPSGNVIAAHGLGQVTQTVLLNNPNKVSLKMRV 760

  Fly   699 KLPYND----LQTTFVIVEFPPDAANSIATFG 726
            ::.|:|    ||.|..|..||..:.||..:.|
Zfish   761 RVSYSDQGTMLQDTVQIDSFPSPSWNSQPSIG 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	164/812 (20%)
		HEAT repeat	402..427	CDD:293787	5/24 (21%)
		HEAT repeat	439..465	CDD:293787	4/26 (15%)
		HEAT repeat	475..505	CDD:293787	7/33 (21%)
		HEAT repeat	512..538	CDD:293787	8/25 (32%)
		COP-gamma_platf	620..761	CDD:285908	30/144 (21%)
		Coatomer_g_Cpla	763..877	CDD:292991
ap1g2	NP_001276787.1	Adaptin_N	23..574	CDD:279882	111/578 (19%)
ap1g2	NP_001276787.1	Alpha_adaptinC2	675..781	CDD:197886	21/109 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910