DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gammaCOP and ap3b2

DIOPT Version :9

Sequence 1:	NP_001263145.1	Gene:	gammaCOP / 43717	FlyBaseID:	FBgn0028968	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_021326282.1	Gene:	ap3b2 / 100000165	-ID:	-	Length:	1091	Species:	Danio rerio

Alignment Length:	859	Identity:	161/859 - (18%)
Similarity:	308/859 - (35%)	Gaps:	245/859 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 IHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDVVLRRMVYLGIKELSSIAEDVIIVT-SS 108
            :..:.:|:.:|.:|     :.|:|.|.|:.|....|::.::::||:.:...:...:|:.::: |:
Zfish    11 LEAMKRIVAMIARG-----KNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSIST 70

  Fly   109 LTKDMTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQCIVD------KNAAVSCAAL------- 160
            ..:.:.....|.||:|:|.|.||....::..:...:|:...|      |.||.:...|
Zfish    71 FQRGLKDPNQLIRASALRVLSSIRVTIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLHSLDPDQ 135

  Fly   161 ------VSSLRLAN----TAGDVVKRWANEAQEALNSDNIMVQYHAL-GLLYHIRKSDRLAVSKL 214
                  |....||:    .||.||..:.....:.:  |.|...|..| .||..:.:..::.:..:
Zfish   136 KDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPDRI--DLIHKNYRKLCNLLIDVEEWGQVVIINM 198

  Fly   215 VNKLTRGSLKSPYAVCMLIRIACKLIEE---------EDIPSEELSDSPLFTFIESCLRHKSEMV 270
            :.:..|....:|       .|...|:||         :|   ||..|..    .|:....|.:..
Zfish   199 LTRYARTQFLNP-------NINESLLEEGSEKAFYASDD---EEDEDKK----AEAAALAKRKPY 249

  Fly   271 IYEAAHAIVNLKNTNP----RMLSPAFSILQL-FCSSPKATLRFAAVRTLNKVAMTHPAA----- 325
            :.:..|.:: |:||.|    |..:...::.|| |..:|||.:...| :.|.::..:|...
Zfish   250 VMDPDHRLL-LRNTKPLLQSRNAAVVMAVAQLYFHLAPKAEVGVIA-KALVRLMRSHSEVQYVVL 312

  Fly   326 --VTTCNLDLEGLI-----------TDSNRSVATLAITTLLKTGAESSVERLMKQISTFVAEISD 377
              |.|..:...|:.           ||..: :..|.:..|.....|:::..::::..|::..:..
Zfish   313 QNVATMTIKRRGMFEPYLKSFYIRSTDPTQ-IKILKLEVLTNLANETNISTILREFQTYIKSMDK 376

  Fly   378 EFKVVVVQAICALCTKYPRKHTVLMNFLSGMLREEGGLEYKTSIVDTIITIIEENADAKESGLSH 442
            :|....:|||....|.........:|.|..:|.....|....|:| .|..:::...:.....:.|
Zfish   377 DFVAASIQAIGRCATNIGEVRDTCLNGLVQLLSNRDELVVAESVV-VIKKLLQMQPEQHSDIIKH 440

  Fly   443 LCEFIEDCEHVSLAVRILHLLGKEGPFAATPSKYIRFIYNRVILESPIVRAAAVTAMAQFGASCP 507
            :.:.|::                                    ::.|:.||:.:..:.::....|
Zfish   441 MAKLIDN------------------------------------IQVPMARASILWLIGEYCEHVP 469

  Fly   508 ALLSNILVLLGRCQMDPDDEVRDR-----ATYYLSILNSERPELYKNYIIERENCSLALLEKSLV 567
            .:..::|..:.:...:.:|.|:.:     |..||:  ||::.:|...|::            :|.
Zfish   470 KIAPDVLRKMAKTFTNEEDIVKLQIINLAAKLYLT--NSKQTKLLTQYVL------------NLA 520

  Fly   568 EHLNGDVDTRFDIS---------IVP---KAAIVKPVIANDVMLVTSSAP--RPPKITREEESAA 618
            ::     |..:||.         |||   ..|:.|  .|..:.|....||  ..|...|:.....
Zfish   521 KY-----DQNYDIRDRARFIRQLIVPTDKSGALSK--YAKKLFLALKPAPVLESPFKDRDHFQLG 578

  Fly   619 RLAQLPGIQVLG----PIHRSTAPIQLTESETEYTVQCIKHIFGQHVVFQFDCLNTLSDQILENV 679
            .|:.|...:..|    |....:||                                  |..:.||
Zfish   579 SLSHLLNAKASGYQELPDWPESAP----------------------------------DPSVRNV 609

  Fly   680 RVELTLPEGFTTRAVIP----C-----------PKLPYNDLQTTFVIVEFPPDAANSIATFGATL 729
            .| :.|.|..||...||    |           .|..|:|.:..    ..|.::|:|.:..|:..
Zfish   610 EV-IRLLERVTTLTSIPEWSKCTSRKDRKEKKVEKPFYSDSEGE----SGPTESADSESDSGSGS 669

  Fly   730 RFVV-----------KDCDPNTGEPESEEGYDDEYMLEDLELTVADQIQKTRKNNFQVS------ 777
            ....           .:.:.:..|.||||..:||   ||         ||.:|...:.:
Zfish   670 ESASGSEESRSARSGSESEDSGEESESEEEEEDE---ED---------QKKKKKRLEKTKARKAV 722

  Fly   778 WDAADSEEWLQAED 791
            .::|:||:...|||
Zfish   723 EESAESEQSSGAED 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gammaCOP	NP_001263145.1	SEC21	11..877	CDD:227565	161/859 (19%)
		HEAT repeat	402..427	CDD:293787	7/24 (29%)
		HEAT repeat	439..465	CDD:293787	2/25 (8%)
		HEAT repeat	475..505	CDD:293787	3/29 (10%)
		HEAT repeat	512..538	CDD:293787	6/30 (20%)
		COP-gamma_platf	620..761	CDD:285908	33/170 (19%)
		Coatomer_g_Cpla	763..877	CDD:292991	9/35 (26%)
ap3b2	XP_021326282.1	Adaptin_N	1..543	CDD:307641	111/611 (18%)
		HEAT repeat	67..94	CDD:293787	8/26 (31%)
		HEAT repeat	101..131	CDD:293787	6/29 (21%)
		HEAT repeat	138..164	CDD:293787	7/25 (28%)
		AP3B1_C	806..948	CDD:317233
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910