DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mey and F52C9.5

DIOPT Version :9

Sequence 1:	NP_001287622.1	Gene:	mey / 43715	FlyBaseID:	FBgn0039851	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001367876.1	Gene:	F52C9.5 / 186097	WormBaseID:	WBGene00018675	Length:	645	Species:	Caenorhabditis elegans

Alignment Length:	430	Identity:	97/430 - (22%)
Similarity:	144/430 - (33%)	Gaps:	127/430 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LSVEPAEAIAASPPGSIGDSSGASAAAPVPPAAASAAAVAETKADDLD----------------P 123
            ||:...|:.:::|.....||      .|.||.:|...|:| |..|..|                |
Worm   219 LSMINGESSSSAPSSEDEDS------PPSPPPSAPIVALA-TNTDKRDEHEEMTETIEDITVASP 276

  Fly   124 TPMATPSGSSSVDEDCEPDMIGFELITGYVLSAPSKQLETLPGTLMLTDCLEACQANE------S 182
            :..:.|.|..|.....|    ||||.:       ....|.:.|.  :.:|.:||..|:      .
Worm   277 SSDSCPRGKQSTFLRTE----GFELFS-------HDDQELVVGD--VAECAKACIENKINGVALK 328

  Fly   183 CSAVNY--ETGLCVMFRSTADQLP---GSLSRSQYPVFTVYAQKSCFG---VRPCSKAWCIDRVQ 239
            |.:.::  .|..|. |.|.| .:|   |.|.:.:   ...|.:|.|..   |..|...:.....|
Worm   329 CKSFDFLSSTSTCA-FTSEA-AVPVGNGQLKQRE---DASYHEKICVSKSFVESCPSTFFSRHPQ 388

  Fly   240 ----GYRLPERAKASQSVATRRDCIELCLGETE---FTCRSANYYAHSGL--CELSDMDRIT--- 292
                |:     |::.....:...|.:.||...:   |.|.|..||.....  |.|:..:|.|
Worm   389 MILVGF-----AESVSDSPSFEHCFDTCLNSYQLFGFNCTSGMYYFEENQLNCILNSENRNTQRE 448

  Fly   293 LSDEANIAAYDGADYLENNCAEEPSKLCEFKRVAGRILKTVDSV--------HQNV-------QT 342
            |..|.|.   |..||.|..|....||..:.|....|..:| |::        |::|       ::
Worm   449 LFTEENT---DIVDYFEVECTTPRSKQSKRKMAGVRNFET-DAIGADKMVTDHEDVEEDGSKWES 509

  Fly   343 LDECRDLCLTAPFRCHSYDYNE------------------------TGELVCRLSHHSRATLTDL 383
            ..||:|...|....|.:::..|                        .|||............||.
Worm   510 WSECQDGKQTRRKICANFNQIEDCAEEVRDCVDEIDSTDMRMSIKRAGELENNDHEQIEDNNTDA 574

  Fly   384 SE-PYLSIEEAATYEQ-----------SACYNVSIDCRSG 411
            || |..:.||.|..:|           :.|..|.:.|..|
Worm   575 SEDPVPTKEEIAEVKQKIRRTGFKCPLNECCRVFLSCSYG 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mey	NP_001287622.1	PAN_1	146..223	CDD:278453	20/87 (23%)
		PAN_AP_HGF	233..311	CDD:238532	22/89 (25%)
		PAN_AP_HGF	319..>380	CDD:238532	15/99 (15%)
		ZP	408..642	CDD:214579	2/4 (50%)
F52C9.5	NP_001367876.1	PAN_AP	132..213	CDD:214680
		PAN_1	287..369	CDD:394981	23/99 (23%)
		PAN_AP_HGF	383..462	CDD:238532	21/86 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157388
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030