DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mey and cutl-17

DIOPT Version :9

Sequence 1:	NP_001287622.1	Gene:	mey / 43715	FlyBaseID:	FBgn0039851	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001379101.1	Gene:	cutl-17 / 185474	WormBaseID:	WBGene00009541	Length:	912	Species:	Caenorhabditis elegans

Alignment Length:	734	Identity:	148/734 - (20%)
Similarity:	267/734 - (36%)	Gaps:	220/734 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 FELITGYVLSAPSKQLETLPGTLMLTDCLEACQANES-----C-SAV-NYETGLCVMFRSTADQL 203
            ||.....:|...:.::.|:.|   |:|||..|..::.     | ||: .||||.|:|.|......
Worm   119 FERYPQSILIGHAMKVLTVDG---LSDCLSKCALSQRSYDFLCKSAIYYYETGECIMNRDNKFIY 180

  Fly   204 PGSLSRSQYPVFTVYAQKSCFGVRPCSKA----WCIDRVQGYRLPERAKASQSVATRRDCIELC- 263
            |.....:.......|.:.:|..| .|...    |.  |.:.|.:.|........:..::|.:||
Worm   181 PKLFKTNILDTLVDYFENNCADV-SCKPEETLHWV--RTEEYLIDESKDVIVESSDAQECNQLCQ 242

  Fly   264 ---LGETEFTCRS---------------ANYYAHSGLCELSDMDRITLSDEANIAAYDGADYLEN 310
               :||..|.|::               ::|..|.|            ....|:|..:..:|.|.
Worm   243 NNKIGEENFPCKAFAYSNSKQECHLTAESSYVGHKG------------DKRFNLAPLNSGEYFEK 295

  Fly   311 NCAEEPSKL----CEFKRVAGRIL----KTVDSVHQNVQTLDECRDLCLTAPFRCHSYDYNETGE 367
            .|.  |:.|    ..|:.||.|::    ||:.::.|:     ||...|:....||.|..|....:
Worm   296 YCL--PTNLQCIEASFELVANRMMTSAYKTISALSQH-----ECLSQCMNDGARCSSATYFYMDD 353

  Fly   368 LVCRLSHHSR---------ATLTDL---------SEPYLSI-------------EEAATYEQS-- 399
             .|:||..|:         |..||.         .:|.|:.             ||..|.|:|
Worm   354 -ECQLSDISQFSRPNEFVVANFTDYFDKICDPADPKPMLTTPETPPELIQNSVDEEETTSERSIA 417

  Fly   400 ------------------------------ACYNV------------------------------ 404
                                          |.:.|
Worm   418 QGAANFEVATTGTSVEFEDDNLLKDNQAVDAVHGVTTTTNIGEKRETKVEIEETVIDDADEFSRE 482

  Fly   405 ------------------------SIDCRSGEMITKIRTSKLFDGKVYAKGAPKSCAVNVNNSLE 445
                                    |.:||...:...::.:....|.:|.|....||..:.:|:..
Worm   483 IDDSHEESPLTSSEESEGRVKARLSTECRMSGISVSLKFATPTSGTIYIKDHFSSCRQSFSNTSF 547

  Fly   446 FDLKMRY---NDLECNVRQSAYGRYMNDIVIQHHDM----IVTSSDLGLAVSCQYD-LTNKTVVN 502
            .:|.:.:   :|.:|...:|...::..::|::.:||    :||:.|....|||.:. :.:|..:.
Worm   548 AELHIPFPTEDDSKCGGIESEPHKWDYNVVVERNDMKTPSLVTTKDKTFQVSCDFSKIADKNQLA 612

  Fly   503 NVDLGVTGEIESTLSEEIIVDSPNVIMKITARDGSDMKRIAEVGDPLALRFEIVDANSPYEIFVR 567
            .:...|.|:::          |..|:|:| .|:|..:..: .:|..::||:.::|.......|:.
Worm   613 ALKPKVEGDVK----------SEKVLMEI-VRNGQAVTTV-PLGAEVSLRWTVIDETDKLGFFIN 665

  Fly   568 ELVA--MDGTDS-AEITLIDANGCPTDQYIMSAM-QKLANNRKVLLSQFDAFKFPSSELVQFRAL 628
            |.:|  :.|... .|...|...|||.::.....: ..:..|.:|..::...|:|..|..|:.:..
Worm   666 ECIAERVGGQPPYPEPLKIIYQGCPEEKVRNRLLHDPVVKNGEVYSTKMKVFRFDGSRRVRIKCS 730

  Fly   629 VTPCIPRCEPVICDNDENGELKSLLSYGRRKRSVLNGTDGVELAIKSERQKRDVSHQAAGDENIL 693
            :..|:.:|.|||||   :.|::::.|:||:||:     ..||..:|:..:|.....:       :
Worm   731 IDVCVEKCPPVICD---DLEIRNVDSFGRKKRN-----SNVEKWLKAGNKKETRKRR-------M 780

  Fly   694 LVQSIQITDKFAFNGADAP 712
            :..::.|||:...|....|
Worm   781 VTGTLTITDEEETNTTVKP 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mey	NP_001287622.1	PAN_1	146..223	CDD:278453	22/83 (27%)
		PAN_AP_HGF	233..311	CDD:238532	18/96 (19%)
		PAN_AP_HGF	319..>380	CDD:238532	20/77 (26%)
		ZP	408..642	CDD:214579	54/245 (22%)
cutl-17	NP_001379101.1	PAN_1	26..106	CDD:394981
		PAN_AP_HGF	114..199	CDD:238532	22/82 (27%)
		PAN_AP	208..295	CDD:214680	17/100 (17%)
		PAN_AP_HGF	308..380	CDD:238532	21/77 (27%)
		Zona_pellucida	509..744	CDD:421542	54/246 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I5679
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H119456
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17001
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	7.000