DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mey and noah-1

DIOPT Version :9

Sequence 1:	NP_001287622.1	Gene:	mey / 43715	FlyBaseID:	FBgn0039851	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001250022.1	Gene:	noah-1 / 172261	WormBaseID:	WBGene00016422	Length:	1052	Species:	Caenorhabditis elegans

Alignment Length:	738	Identity:	166/738 - (22%)
Similarity:	276/738 - (37%)	Gaps:	203/738 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 ATPSGSSSVDEDCEPDMIGFELITGYVLSAPSKQLETLPGTLMLTDCLEAC--QANESCSAVNYE 189
            |.|.|.|.:                :||.|.:.:        .:.:|:..|  .|.|.|.:.||:
Worm   402 ALPEGESEL----------------HVLKASAAK--------GIKECVAKCFGLAPEKCRSFNYD 442

  Fly   190 --TGLCVMFRSTADQLPGSLSRSQYPVFTVYAQKSCFGV-RPCS--------KAWCIDRVQGYRL 243
              |..|.:.............|....::.::    |..| ..||        ..:...:.:|  :
Worm   443 KKTKSCDLLYLDGHNTLQPQVRQGVDLYDLH----CLAVENDCSANKDDALFSRYLHTKQRG--I 501

  Fly   244 PERAKASQSVATRRDCIELCLGETEFTCRSANYYAHSGLCELSDMDRITLSDEANIAAYDGADYL 308
            |.:.   ..|.:...|:|:|.|..  ||..|||....|.|.|.|    .:.|:|.|..:  .|:.
Worm   502 PAKV---YKVVSLNSCLEVCAGNP--TCAGANYNRRLGDCTLFD----AIDDDAEINEH--TDFY 555

  Fly   309 ENNC--------AEEPSKLCEFK-RVAGRILKTVDSVHQNVQTLDECRDLCLTAPFRCHSYDYNE 364
            :|.|        |...:.:.|.| ||:|.:::..||..|.:.|                    .:
Worm   556 KNLCVTKEIDTGASAAANVPETKHRVSGTVVEGKDSKSQLLAT--------------------KK 600

  Fly   365 TGELVCRLSHHSRA--TLTDLSEPYLSIEEAATYEQSAC--YNVSIDCRSGEMITKIRTSKLFDG 425
            ..:...:.:.|.||  :...:..|   :|..|...|:.|  ..:.:...:||.         |.|
Worm   601 VKKPTIKNTEHRRAPESTVPIGPP---VEVKAEAIQTICNYEGIKVQINNGEP---------FSG 653

  Fly   426 KVYAKGAPKSCAVNVNNS--------LEFDLKMRYNDL--------------------------- 455
            .::.|....:|.|.|.||        |..|..||...|
Worm   654 VIFVKNKFDTCRVEVANSNAATLVLGLPKDFGMRPISLDNIDDNETGKNKTKKGEETPLKDEIEE 718

  Fly   456 -----------ECNVRQSAYGRYMNDIVIQHHDM----IVTSSDLGLAVSCQY-DLTNKTVVNNV 504
                       :|.:.....|.|.:.:|||.:::    :|||.|....|||.| .:....|....
Worm   719 FRQKRQAAEFRDCGLVDLLNGTYKSTVVIQTNNLGIPGLVTSMDQLYEVSCDYSSMLGGRVQAGY 783

  Fly   505 DLGVTGEIESTLSE---EIIVDSPNVIMKITARDGSDMKRI-AEVGDPLALRFEIVDANSPYEIF 565
            ::.|||. |:.|.:   :|.:.:| |:|::...||::...: |::||.|.||:||:..:...:.|
Worm   784 NMTVTGP-EANLIQPRGKIELGNP-VLMQLLNGDGTEQPLVQAKLGDILELRWEIMAMDDELDFF 846

  Fly   566 VRELVAMDGTDSA------EITLIDANGCPTDQYIMSAMQKL------ANNRKVLLSQFDAFKFP 618
            |:...|..|....      ::.||| .||||.    :..|||      ..:..|..::..||:|.
Worm   847 VKNCHAEPGVAGGKAGAGEKLRLID-GGCPTP----AVAQKLIPGAIEIKSSAVKTTKMQAFRFD 906

  Fly   619 SSELVQFRALVTPCIPRCEPVICDNDENGELKSLLSYGRRKRSVLNGTDGVELAIKSERQKRDVS 683
            ||..::....|..|...||||.|  ...|.:|.  |:||:||.|.|..:      :.|..:..:.
Worm   907 SSASIRVTCEVEICKGDCEPVEC--ALTGGVKK--SFGRKKREVSNNIE------EFETNRYLIP 961

  Fly   684 HQAAGDENILLVQSIQ-----ITDKFAFNGADAPGGSGSEAGGLDGLAK--LQLDLGTKSDTCIN 741
            .::....:|:::..:|     :.:..|.          |.|..||.|.:  .::.:..:...|:|
Worm   962 RRSHATTSIVIIDPLQQVCTKVNEPVAM----------SRASTLDLLREDAHEVQMIEEGSICLN 1016

  Fly   742 GYG-FIIAGALFLLL--QLTVIA 761
            ... |.|.|.|.:|:  |..|||
Worm  1017 SVTVFAIFGTLAVLILGQTVVIA 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mey	NP_001287622.1	PAN_1	146..223	CDD:278453	13/80 (16%)
		PAN_AP_HGF	233..311	CDD:238532	20/77 (26%)
		PAN_AP_HGF	319..>380	CDD:238532	12/63 (19%)
		ZP	408..642	CDD:214579	75/300 (25%)
noah-1	NP_001250022.1	PAN_AP_HGF	107..189	CDD:238532
		PAN_AP_HGF	201..282	CDD:238532
		PAN_AP_HGF	295..379	CDD:238532
		PAN_AP_HGF	391..473	CDD:238532	17/94 (18%)
		PAN_APPLE	485..557	CDD:294081	20/84 (24%)
		Zona_pellucida	<818..920	CDD:278526	29/106 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I5679
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H119456
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005301
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010