DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl1 and loxl2a

DIOPT Version :9

Sequence 1:	NP_524607.1	Gene:	Loxl1 / 43712	FlyBaseID:	FBgn0039848	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001092714.1	Gene:	loxl2a / 565508	ZFINID:	ZDB-GENE-070818-1	Length:	737	Species:	Danio rerio

Alignment Length:	308	Identity:	137/308 - (44%)
Similarity:	178/308 - (57%)	Gaps:	13/308 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EGRVEVSFDFGAS--WGTICSTSWSMREANVVCRQLGLGYASKASQGTEH--GDSRKYPWGMVGT 110
            ||||||..:...|  |||:||.:|.:.||.|||||||||:||.|.|.|.:  ||:......|.|.
Zfish   413 EGRVEVLAEKNGSLVWGTVCSENWGIIEAMVVCRQLGLGFASHAFQETWYWAGDANADNVVMSGV 477

  Fly   111 LCRGTERRLADCIRESHYPNLCNARNHNVSIAACVSHSADLEIGLVDIERTARLEAVPMSRLTCA 175
            .|.|||..|..|:....:.|.........:..:|...:.||.:....:|:|..||..||..|.||
Zfish   478 RCSGTEMSLPQCLHHGKHINCPKGGGRFAAGVSCSDTAPDLVLNAQLVEQTTYLEDRPMYALQCA 542

  Fly   176 MEEHCVSADAYEIRRTNPHAA-RILLRFSVKASNVGTADVSPYANYKEWVWHQCHRHYHSMNVFA 239
            :||:|:|:.|    |.|.|:: |.|||||.:..|||.:|..|...|..|.||:||||||||.||.
Zfish   543 LEENCLSSTA----RKNDHSSYRRLLRFSSQIHNVGQSDFRPKLGYHAWTWHECHRHYHSMEVFT 603

  Fly   240 TFDVYDLNYRKVAQGHKASFCLMDSECRPGVRQKYTCGN-TTQGISVGCADTYTDVLDCQWVDVT 303
            .:|:..||..|||:||||||||.|:.|..|:.::|.|.| ..|||:|||.|||...:||||:|||
Zfish   604 HYDLLSLNGTKVAEGHKASFCLEDTHCDEGISKRYHCANFGEQGITVGCWDTYRHDIDCQWIDVT 668

  Fly   304 RVPINRRYILRVALNPEYKLGEISFENNGAECLLDYTGVRQTTRIFNC 351
            .|... .||.:|.:||.|.:.|..:.||..:|...|.|.|..|  ::|
Zfish   669 DVKPG-DYIFQVVINPNYDVAESDYTNNVMKCKCRYDGYRIWT--YSC 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl1	NP_524607.1	SRCR	50..137	CDD:278931	40/90 (44%)
		SR	50..136	CDD:214555	40/89 (45%)
		Lysyl_oxidase	149..343	CDD:279521	93/195 (48%)
loxl2a	NP_001092714.1	SR	29..130	CDD:214555
		SRCR	38..130	CDD:278931
		SR	173..269	CDD:214555
		SRCR	173..269	CDD:278931
		SR	294..393	CDD:214555
		SRCR	299..393	CDD:278931
		SR	403..512	CDD:214555	40/98 (41%)
		SRCR	408..512	CDD:278931	40/98 (41%)
		Lysyl-oxidase like. /evidence=ECO:0000250	516..718		96/205 (47%)
		Lysyl_oxidase	516..709	CDD:279521	94/197 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581831
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KG1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376277at33208
OrthoFinder	1	1.000	-	-		FOG0000389
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.810