DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl1 and Loxl4

DIOPT Version :9

Sequence 1:	NP_524607.1	Gene:	Loxl1 / 43712	FlyBaseID:	FBgn0039848	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_001101062.1	Gene:	Loxl4 / 309380	RGDID:	1308588	Length:	758	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	139/320 - (43%)
Similarity:	179/320 - (55%)	Gaps:	13/320 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 NKAALAGIQVLREGRVEVSFDFGA--SWGTICSTSWSMREANVVCRQLGLGYASKASQGTEH--G 98
            ||..|||.:...||.|||..:...  .|||:||..|.:.||.|.|||||||:|:.|.:.|.:  |
  Rat   421 NKVRLAGGRNSEEGVVEVQVEVNGVPRWGTVCSDHWGLTEAMVTCRQLGLGFANFAIKDTWYWQG 485

  Fly    99 DSRKYPWGMVGTLCRGTERRLADCIRESHYPNLCNARNHNVSI-AACVSHSADLEIGLVDIERTA 162
            ........|.|..|.|||..|..|.|  |.|..|:..:...|. .||::.:.||.:....::.||
  Rat   486 TPEAKEVVMSGVRCSGTEMALQQCQR--HGPVHCSHGSGRFSAGVACMNSAPDLVMNAQLVQETA 548

  Fly   163 RLEAVPMSRLTCAMEEHCVSADAYEIRRTNPHAARILLRFSVKASNVGTADVSPYANYKEWVWHQ 227
            .||..|:|.|.||.||:|:|..|..:  ..|:..|.|||||.:..|:|.||..|.|....|:|||
  Rat   549 YLEDRPLSMLYCAHEENCLSKSADHM--DWPYGHRRLLRFSSQIYNLGRADFRPKAGRHSWIWHQ 611

  Fly   228 CHRHYHSMNVFATFDVYDLNYRKVAQGHKASFCLMDSECRPGVRQKYTCGN-TTQGISVGCADTY 291
            |||||||:.||..:|:..||..|||:||||||||.|:.|..||:::|.|.| ..||::|||.|||
  Rat   612 CHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPSGVQRRYACANFGEQGVAVGCWDTY 676

  Fly   292 TDVLDCQWVDVTRVPINRRYILRVALNPEYKLGEISFENNGAECLLDYTGVRQTTRIFNC 351
            ...:||||||:|.|... .||.:|.:||...:.|..|.||...|...|.|  |...:.||
  Rat   677 RHDIDCQWVDITDVSPG-DYIFQVVVNPTNDVAESDFSNNMIRCRCKYDG--QRVWLHNC 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl1	NP_524607.1	SRCR	50..137	CDD:278931	37/90 (41%)
		SR	50..136	CDD:214555	37/89 (42%)
		Lysyl_oxidase	149..343	CDD:279521	91/194 (47%)
Loxl4	NP_001101062.1	SR	33..133	CDD:214555
		SRCR	42..133	CDD:278931
		SR	175..287	CDD:214555
		SRCR	177..287	CDD:278931
		SR	313..413	CDD:214555
		SRCR	318..413	CDD:278931
		SR	447..530	CDD:214555	33/84 (39%)
		SRCR	447..530	CDD:278931	33/84 (39%)
		Lysyl_oxidase	535..730	CDD:279521	92/199 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KG1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376277at33208
OrthoFinder	1	1.000	-	-		FOG0000389
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45817
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.880