DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl1 and Loxl2

DIOPT Version :9

Sequence 1:	NP_524607.1	Gene:	Loxl1 / 43712	FlyBaseID:	FBgn0039848	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	XP_038949076.1	Gene:	Loxl2 / 290350	RGDID:	1308435	Length:	823	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	137/320 - (42%)
Similarity:	179/320 - (55%)	Gaps:	15/320 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KAALAGIQVLREGRVEVSFDFGAS--WGTICSTSWSMREANVVCRQLGLGYASKASQGT--EHGD 99
            |..|.|.:...||||||..:...|  ||.:|..:|.:.||.|||||||||:||.|.|.|  .||:
  Rat   484 KVRLNGGRNPYEGRVEVLTERNGSLVWGNVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGN 548

  Fly   100 SRKYPWGMVGTLCRGTERRLADCIRESHYPNLC--NARNHNVSIAACVSHSADLEIGLVDIERTA 162
            .......|.|..|.|||..||.|..:...  :|  ....:...: ||...:.||.:....:::||
  Rat   549 IFANKVIMSGVKCSGTELSLAHCRHDEEV--VCPEGGVQYGAGV-ACSETAPDLVLNAEIVQQTA 610

  Fly   163 RLEAVPMSRLTCAMEEHCVSADAYEIRRTNPHAARILLRFSVKASNVGTADVSPYANYKEWVWHQ 227
            .||..||:.|.|||||:|:||.|.....|..|  |.|||||.:..|.|.:|..|......|:||.
  Rat   611 YLEDRPMALLQCAMEENCLSASAVHTDPTRGH--RRLLRFSSQIHNNGQSDFRPKNGRHAWIWHD 673

  Fly   228 CHRHYHSMNVFATFDVYDLNYRKVAQGHKASFCLMDSECRPGVRQKYTCGN-TTQGISVGCADTY 291
            ||||||||.||..:|:..||..|||:||||||||.|:||...:::.|.|.| ..|||::||.|.|
  Rat   674 CHRHYHSMEVFTYYDLLSLNGTKVAEGHKASFCLEDTECEGDIQKSYECANFGEQGITMGCWDMY 738

  Fly   292 TDVLDCQWVDVTRVPINRRYILRVALNPEYKLGEISFENNGAECLLDYTGVRQTTRIFNC 351
            ...:||||:|:|.||.. .|:.:|.:||.|::.|..|.||..:|...|.|.|  ..::||
  Rat   739 RHDIDCQWIDITDVPPG-DYLFQVVINPNYEVPESDFSNNIMKCRSRYDGYR--IWMYNC 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl1	NP_524607.1	SRCR	50..137	CDD:278931	39/92 (42%)
		SR	50..136	CDD:214555	39/91 (43%)
		Lysyl_oxidase	149..343	CDD:279521	90/194 (46%)
Loxl2	XP_038949076.1	SR	73..174	CDD:214555
		SR	216..316	CDD:214555
		SR	348..475	CDD:214555
		SR	485..593	CDD:214555	42/110 (38%)
		Lysyl_oxidase	598..797	CDD:395944	93/203 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341806
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KG1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D376277at33208
OrthoFinder	1	1.000	-	-		FOG0000389
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45817
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.810