Protein Alignment Loxl1 and DMBT1

DIOPT Version :10

• Sequence 1: NP_524607.1
• Gene: Loxl1 / 43712
• FlyBaseID: FBgn0039848
• Length: 360
• Species: Drosophila melanogaster
• Sequence 2: NP_001364459.1
• Gene: DMBT1 / 1755
• HGNCID: 2926
• Length: 2542
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 74/322 - (22%)
• Similarity: 113/322 - (35%)
• Gaps: 77/322 - (23%)

  Fly    51 GRVEVSFDFGASWGTICSTSWSMREANVVCRQLGLGYASKASQGTEHGDSRKYPWGMVGTLCRGT 115
            ||||:.  .|.:|||:|..||:::||.|||||||.|.|..| .|..:..|...|..:....|.||
Human  2026 GRVEIY--HGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSA-LGNAYFGSGSGPITLDDVECSGT 2087

  Fly   116 ERRLADCIRESHYPNLCNARNHNVSIAACVSHSADLEIGLVDIERTARLEAVPMSRLTCAMEEHC 180
            |..|..|.....:.:.||.|.               :.|::                 |:...
Human  2088 ESTLWQCRNRGWFSHNCNHRE---------------DAGVI-----------------CSGNH-- 2118

  Fly   181 VSADAYEIRRTNPHAARILLRFSVKASNVGTADVSP--YANYKEWVWH-QCHRHYHSMNVFAT-- 240
            :|..|..:..|.|:.......|..:.|...::...|  |.|..:.||. :...:|....:|..
Human  2119 LSTPAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQ 2183

  Fly   241 ---------FDVYDLNYR------KVAQGHKASFC----------LMD-SECRPGVRQKYTCGNT 279
                     .:|:|..||      :|..|.:.||.          :.| |..|.|.|.:|....:
Human  2184 LEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPS 2248

  Fly   280 TQGISVGC---------ADTYTDVLDCQWVDVTRVPINRRYILRVALNPEYKLGEISFENNG 332
            ....::.|         :.:|...|.....|:.....|..|..|..:.|...:..|.:...|
Human  2249 NDSTNLLCLPNHMQASVSRSYLQSLGFSASDLVISTWNGYYECRPQITPNLVIFTIPYSGCG 2310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Loxl1	NP_524607.1	SR	50..136	CDD:214555	34/84 (40%)
		Lysyl_oxidase	149..351	CDD:460102	39/224 (17%)
DMBT1	NP_001364459.1	SR	102..202	CDD:214555
		SR	234..334	CDD:214555
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..356
		SR	363..463	CDD:214555
		SR	494..594	CDD:214555
		SR	602..702	CDD:214555
		SR	733..833	CDD:214555
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	836..855
		SR	862..962	CDD:214555
		SR	993..1093	CDD:214555
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1093..1114
		SR	1122..1222	CDD:214555
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1222..1243
		SR	1251..1351	CDD:214555
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1351..1372
		SR	1380..1480	CDD:214555
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1480..1501
		SR	1509..1609	CDD:214555
		SR	1638..1738	CDD:214555
		SR	1769..1869	CDD:214555
		CUB	1904..2003	CDD:214483
		SR	2012..2115	CDD:214555	36/123 (29%)
		CUB	2137..2245	CDD:238001	23/107 (21%)
		ZP	2256..2508	CDD:214579	10/55 (18%)