DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Loxl1 and Cd5l

DIOPT Version :9

Sequence 1:	NP_524607.1	Gene:	Loxl1 / 43712	FlyBaseID:	FBgn0039848	Length:	360	Species:	Drosophila melanogaster
Sequence 2:	NP_033820.2	Gene:	Cd5l / 11801	MGIID:	1334419	Length:	352	Species:	Mus musculus

Alignment Length:	233	Identity:	63/233 - (27%)
Similarity:	85/233 - (36%)	Gaps:	70/233 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EGRVEVSFDFGASWGTICSTSWSMREANVVCRQLGLGYA-------SKASQGTEHGDSRKYPWGM 107
            :|||||...  :.|.|:|...|:::.:.|||||||.|.|       :|.:||       |.|..|
Mouse   151 QGRVEVLHQ--SQWSTVCKAGWNLQVSKVVCRQLGCGRALLTYGSCNKNTQG-------KGPIWM 206

  Fly   108 VGTLCRGTERRLADCIRESHYPNLCNARNHNVSIAACVSHSAD--------LEIGLV--DIERTA 162
            ....|.|.|..|..|:. |...|.|             :|..|        .|:.||  |...:.
Mouse   207 GKMSCSGQEANLRSCLL-SRLENNC-------------THGEDTWMECEDPFELKLVGGDTPCSG 257

  Fly   163 RLEA--------------------VPMSRLTCAMEEHCVSADAYEIRRT-NPHAARILLRFSVKA 206
            |||.                    |...:|.|....|    .:.:.|:. .|.|.||.|. .|..
Mouse   258 RLEVLHKGSWGSVCDDNWGEKEDQVVCKQLGCGKSLH----PSPKTRKIYGPGAGRIWLD-DVNC 317

  Fly   207 SNVGTADVSPYANYKEWVWHQCHRHYHSMNVFAT-FDV 243
            |  |......:..::.|.:|.| .|...:.|..| |||
Mouse   318 S--GKEQSLEFCRHRLWGYHDC-THKEDVEVICTDFDV 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Loxl1	NP_524607.1	SRCR	50..137	CDD:278931	32/93 (34%)
		SR	50..136	CDD:214555	32/92 (35%)
		Lysyl_oxidase	149..343	CDD:279521	30/127 (24%)
Cd5l	NP_033820.2	SR	27..127	CDD:214555
		SRCR	32..128	CDD:278931
		SR	141..240	CDD:214555	34/111 (31%)
		SRCR	146..241	CDD:278931	34/112 (30%)
		SR	246..348	CDD:214555	24/109 (22%)
		SRCR	251..348	CDD:278931	22/104 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000389
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000