DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PNPase and zgc:194209

DIOPT Version :9

Sequence 1:	NP_001097990.2	Gene:	PNPase / 43710	FlyBaseID:	FBgn0039846	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_001124264.1	Gene:	zgc:194209 / 570908	ZFINID:	ZDB-GENE-081022-75	Length:	432	Species:	Danio rerio

Alignment Length:	482	Identity:	91/482 - (18%)
Similarity:	155/482 - (32%)	Gaps:	173/482 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 KQNLVVMLEGKGNVVLQQDLLKAIKQGTRE--AQFIIHEIERLQKAYGRQKREVEVA-------- 273
            ::..||.:...|:.:..:...:....|.||  ..||: :.|||.......:..|:|.
Zfish     6 REPAVVKVIADGSTLTHRGEQRVFFHGAREQTLNFIL-QSERLYHTTMLSQSSVKVVLLAVAVGI 69

  Fly   274 ----AEVDPE-----------LGKAVRSMCEMRLREIF--QDSTHDKMSRDNAVNEVRSNVIDKV 321
                :.:|||           .|....:....|.|::|  |....:..:.|...|.....|..|:
Zfish    70 YLIPSPIDPEPYIFEDPPPALEGPLAVNTRLQRGRKLFSGQLKGPESFTADQNGNVYTGTVDGKL 134

  Fly   322 WSSFPDTEPSLITEQFNQTSRTIFREL---IFERGLRCDGRDYDQLRNISCQVDMYKPL----HG 379
            |             :.|..|.....::   |.:.|...|                |:|:    ||
Zfish   135 W-------------RINNESLKFITQMGQNIPQCGFSTD----------------YEPVCGRPHG 170

  Fly   380 SALFQRGQTQVFCTVSLDSQESAMKLDSLAALDSGGLKAKNFMLHYE------FP-PYATG-EVG 436
            ..|.:.||     .:..||.....|:|     .|.|.|.   :||..      .| .:..| |:.
Zfish   171 LRLDRDGQ-----LIVADSYYGLFKVD-----PSTGEKT---LLHSSKDGADGIPFGFLNGLEIS 222

  Fly   437 RIGPV---------GRREMGHGALAERSLLPTLPNDYPFTVRLTSEVLESNGSSSMAS---VCGG 489
            :.|.|         |||.:.:                        ||||:|....:.:   ..|.
Zfish   223 KNGTVFFTDSSSKWGRRHVRY------------------------EVLETNRLGRLLTFDPTSGR 263

  Fly   490 SLALMDA-----GVPVSAP-----AAGVAIGLVTKFENDDTKHLQDYRILTDILGIED------- 537
            ...|:|:     |...|..     .|..:||.:.||.....|......:|.:::|..|
Zfish   264 VRTLLDSLYMPNGFAFSPDEDFLLLAETSIGRIIKFWLKGPKAGMKEVVLNNMIGYPDNIRLSDR 328

  Fly   538 ---YMGDMDMKVAGTR--------KGFTAI-QADLKIPGIPLK----------VVMESLQKATDA 580
               .:|...::.||..        ..:.|: :|.:|:  :||.          ||:|     .|:
Zfish   329 GTFLVGISTVRFAGRLFPPFLDLIGPYPALKRAIVKL--VPLSWYDLLLPKYGVVLE-----LDS 386

  Fly   581 KSNILDIMSEAIREPRKYPKESWPVSE 607
            ...::|    ::.:|..:  .:|.||:
Zfish   387 AGQVID----SLHDPTGH--LTWAVSD 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PNPase	NP_001097990.2	PRK11824	42..751	CDD:236995	91/482 (19%)
zgc:194209	NP_001124264.1	YvrE	84..>325	CDD:225921	58/306 (19%)
		NHL	<106..299	CDD:302697	49/258 (19%)
		NHL repeat	114..149	CDD:271320	7/47 (15%)
		NHL repeat	157..209	CDD:271320	17/80 (21%)
		Str_synth	217..304	CDD:304606	22/110 (20%)
		NHL repeat	218..263	CDD:271320	12/68 (18%)
		NHL repeat	272..299	CDD:271320	5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1185
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900