DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PNPase and Pnpt1

DIOPT Version :9

Sequence 1:	NP_001097990.2	Gene:	PNPase / 43710	FlyBaseID:	FBgn0039846	Length:	771	Species:	Drosophila melanogaster
Sequence 2:	NP_001135843.1	Gene:	Pnpt1 / 360992	RGDID:	1307987	Length:	784	Species:	Rattus norvegicus

Alignment Length:	760	Identity:	426/760 - (56%)
Similarity:	550/760 - (72%)	Gaps:	22/760 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 CL-SLSC-PGGR------------RGIQSSSNGEAPSVEVNFSNGRNMTFSSGRLARFANGTAVC 69
            || .||| |.||            |.:.|.:...|.:|::..   |.:..|||:|||||:|.||.
  Rat    12 CLRPLSCGPLGRPRRHRALSYLQVRALWSGTRSRAVTVDLGH---RKLEISSGKLARFADGCAVV 73

  Fly    70 QMGDTAVMVTAVAKAKPNPGQGFMPLVVDYRLKNAASGRIPMNFMRRELGPSEKEILSARLIDRS 134
            |.||||||||||:|.||:|.| |||||||||.|.||:||||.|::|||:|.|:||||::|:||||
  Rat    74 QSGDTAVMVTAVSKTKPSPSQ-FMPLVVDYRQKAAAAGRIPTNYLRREIGSSDKEILTSRVIDRS 137

  Fly   135 LRPLFHKDYRTETQLVCNMLAMDAVHSPDVLAINAASMALSLSDIPWNGPIGAVRVGLCDGEVLI 199
            :||||...|..:||::||:||:|.::.||:||||.||.||||||||||||:||||:|:.|||.::
  Rat   138 IRPLFPAGYFYDTQVLCNLLAVDGINEPDILAINGASAALSLSDIPWNGPVGAVRIGMIDGECVV 202

  Fly   200 NPTRRELQTSQLDLVVSATKQNLVVMLEGKGNVVLQQDLLKAIKQGTREAQFIIHEIERLQKAYG 264
            ||||:|:.:|.|:|||:...::.:||||.....:||||...|||.|.:..|.||..|::|.|..|
  Rat   203 NPTRKEMSSSTLNLVVAGAPKSQIVMLEASAENILQQDFCHAIKVGVKYTQQIIQSIQQLVKEIG 267

  Fly   265 RQKREVEVAAEVDPELGKAVRSMCEMRLREIFQDSTHDKMSRDNAVNEVRSNVIDKVWSSFPDTE 329
            ..||..:.......|:.|...::...:|..:|.|..|||:|||.|||::|.:..:.:...||:.:
  Rat   268 VAKRTPQKIFTPSAEIVKYTHTIAMEKLYAVFTDYEHDKVSRDEAVNKIRLDTEEHLKEKFPEVD 332

  Fly   330 PSLITEQFNQTSRTIFRELIFERGLRCDGRDYDQLRNISCQVDMYKPLHGSALFQRGQTQVFCTV 394
            ...|.|.||..::.:||.:|.....||||||...||||||:|||:|.||||||||||||||.|||
  Rat   333 QLEIIESFNVVAKEVFRSIILNEYKRCDGRDLTSLRNISCEVDMFKTLHGSALFQRGQTQVLCTV 397

  Fly   395 SLDSQESAMKLDS-LAALDSGGLKAKNFMLHYEFPPYATGEVGRIGPVGRREMGHGALAERSLLP 458
            :.||.||::|.|. :.|::  |:|.||||||||||||||.|.|::..|.|||:|||||||::|.|
  Rat   398 TFDSLESSIKSDQIITAIN--GVKDKNFMLHYEFPPYATNETGKVTGVNRRELGHGALAEKALCP 460

  Fly   459 TLPNDYPFTVRLTSEVLESNGSSSMASVCGGSLALMDAGVPVSAPAAGVAIGLVTKFENDDTKHL 523
            .:|.|:|||:|:|||||||||||||||.|||||||||||||:|:..||||:||||| .|.:...:
  Rat   461 VIPKDFPFTIRVTSEVLESNGSSSMASACGGSLALMDAGVPISSAVAGVAVGLVTK-SNPEKGEI 524

  Fly   524 QDYRILTDILGIEDYMGDMDMKVAGTRKGFTAIQADLKIPGIPLKVVMESLQKATDAKSNILDIM 588
            :|||:||||||||||.||||.|:|||.||.||:|||:|:||:|:|::||::|:||.||..||..|
  Rat   525 EDYRLLTDILGIEDYNGDMDFKIAGTNKGITALQADIKLPGVPVKIIMEAIQQATVAKREILQTM 589

  Fly   589 SEAIREPRKYPKESWPVSETLTVEPQQRAQLIGPSGLHMKRIYLETGTSLTAVDETHFNVFAPSQ 653
            |:.|.:||...||:.||.||:.|...:||:.|||.|.|:|::..|||.:::.|||..|::|||:.
  Rat   590 SKTISKPRASRKENGPVVETVKVPLSKRAKFIGPGGYHLKKLQAETGVTISQVDEETFSIFAPTP 654

  Fly   654 AAMDEAKELIEGYMVKERVPDLEFGGIYTAKITELRDTGVMVILYPSMPPALLHNSQLDQRKIAH 718
            .||.||::.|......::...||||.:|||.|||:|||||||.|||:|...||||||||||||.|
  Rat   655 TAMHEARDFITEICRDDQEQQLEFGAVYTATITEIRDTGVMVKLYPNMTAVLLHNSQLDQRKIKH 719

  Fly   719 PSALNLEVGQEIQVKYFGRDPVSGFMRLSRKVLQGPALGIPRSLN 763
            |:||.||||||||||||||||..|.|||||||||.||..:.::||
  Rat   720 PTALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVLKTLN 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PNPase	NP_001097990.2	PRK11824	42..751	CDD:236995	408/709 (58%)
Pnpt1	NP_001135843.1	PRK11824	47..752	CDD:236995	408/711 (57%)
		RNase_PH_PNPase_1	47..273	CDD:206768	131/229 (57%)
		PNPase	290..363	CDD:281688	26/72 (36%)
		RNase_PH_PNPase_2	366..596	CDD:206769	155/232 (67%)
		KH-I	605..664	CDD:294072	27/58 (47%)
		S1	679..750	CDD:197648	55/70 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353355
Domainoid	1	1.000	204	1.000	Domainoid score	I2853
eggNOG	1	0.900	-	-		E1_COG1185
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12404
Inparanoid	1	1.050	822	1.000	Inparanoid score	I439
OMA	1	1.010	-	-		QHG58167
OrthoDB	1	1.010	-	-		D175537at33208
OrthoFinder	1	1.000	-	-		FOG0005289
OrthoInspector	1	1.000	-	-		oto98737
orthoMCL	1	0.900	-	-		OOG6_102161
Panther	1	1.100	-	-	LDO	PTHR11252
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770