DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gcn2 and EIF2AK3

DIOPT Version :9

Sequence 1:	NP_001263142.1	Gene:	Gcn2 / 43709	FlyBaseID:	FBgn0019990	Length:	1591	Species:	Drosophila melanogaster
Sequence 2:	NP_004827.4	Gene:	EIF2AK3 / 9451	HGNCID:	3255	Length:	1116	Species:	Homo sapiens

Alignment Length:	992	Identity:	228/992 - (22%)
Similarity:	373/992 - (37%)	Gaps:	338/992 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 SSENSSPYYRGH--IYPSK-------CLDHRNTETLYF---------HKMGRQIQRGCCVGEGHS 252
            ||..|.|...|:  |.||.       ..|..:.||:.|         :|.|..:.  ...|:..:
Human   139 SSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVESLLESSYKFGDDVV--LVGGKSLT 201

  Fly   253 QRGCIAYTGIDMHCGQLLYITEWNIKYSQLEQ----------------PCIGGGKCHWS------ 295
            ..|..||:|...:....|...:|:....:.|:                |..|..|.::|
Human   202 TYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQRTQKTVRAVGPRSGNEKWNFSVGHFEL 266

  Fly   296 ------------SESKCMGSHRVDE--VMASIEKQVSSLSQLQHKNLVSYECVLCIKRKEGLLVY 346
                        .||....:...:|  :::.:|:|.:::..:..|..|:...|:...:|.|.|.:
Human   267 RYIPDMETRAGFIESTFKPNENTEESKIISDVEEQEAAIMDIVIKVSVADWKVMAFSKKGGHLEW 331

  Fly   347 LVQDFLLGTSVFSISSSLGWCMDGARMVARGVLDALVFLHNKGVSHSH---------LLDTTVFM 402
            ..|        |....:..|.:...:::...:.|...:..|..|....         ..:.:|::
Human   332 EYQ--------FCTPIASAWLLKDGKVIPISLFDDTSYTSNDDVLEDEEDIVEAARGATENSVYL 388

  Fly   403 DN-------TGNVRVSD-FSLVPNLLELLSGAGQSSSCGDLPAL--GALVESLMPTNSYEMRDFV 457
            ..       ..:||:|: |...|..||.::   ..::...||.:  ..|:.|...|......|..
Human   389 GMYRGQLYLQSSVRISEKFPSSPKALESVT---NENAIIPLPTIKWKPLIHSPSRTPVLVGSDEF 450

  Fly   458 DKCNSDRTLSASE-------LLEHP-----FLRFY---------------VDNGQ---------- 485
            |||.|:...|..|       :|::|     :|.:|               :||..
Human   451 DKCLSNDKFSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDP 515

  Fly   486 -------QQVM-------------------PLPQQQHPNTVQRTGSAMPYQIPTLALSQ------ 518
                   ::::                   |.|.:|...:..:..:...|...:...:.
Human   516 VLLLHWWKEIVATILFCIIATTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDI 580

  Fly   519 ------SRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYK-KMTREVELL 576
                  ||..|:||.:..||:|.||.|.:.:|.:|:..||||||.||  :|:|.: |:.|||:.|
Human   581 KNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLP--NRELAREKVMREVKAL 643

  Fly   577 SRLNHENVVRYFNSWIESVDDADAAEMDKLL----GGEW---SQSQQDL-SVK-----P------ 622
            ::|.|..:|||||:|:|:..:....:||::.    ..:|   |.|..|. |||     |
Human   644 AKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEH 708

  Fly   623 ----AKSPQ------LGPTLEEDE--------------DEEDSSSSMWNGYIPNMEDS------- 656
                |.|||      :|.:.::..              |.||.|.|:...|  |::||
Human   709 IEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAY--NLQDSCLTDCDV 771

  Fly   657 -----------------DSDGIEFVDSNGKVA---VYDD---------EEQEDS----------- 681
                             .|:...:|.|..:.:   |::|         ||.:.:
Human   772 EDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANK 836

  Fly   682 ------TRGKTNS--------PKPL-------------MQ------VMYIQMEFCEKCTL----- 708
                  |..|::|        |:|.             :|      .:||||:.|.|..|
Human   837 LTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMN 901

  Fly   709 -RTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSF 772
             |..|::   .:......:|.:|||.:..:|.:|::||||||.|||....|.:|:|||||.|
Human   902 GRCTIEE---RERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT--- 960

  Fly   773 LALQAHD-----AAPAPVNQITSAEDGTGTGKVGTTLYVAPE-LTGNASKSVYNQKVDMYTLGII 831
             |:...:     ..|.|..       ...||:|||.||::|| :.||:    |:.|||:::||:|
Human   961 -AMDQDEEEQTVLTPMPAY-------ARHTGQVGTKLYMSPEQIHGNS----YSHKVDIFSLGLI 1013

  Fly   832 LFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKDP-----KYEKTVKMLQWLLNHDPAQRPTA 891
            |||:.. ||.|.|||.:|:..:||         ||.|     ||.....|:|.:|:..|.:||.|
Human  1014 LFELLY-PFSTQMERVRTLTDVRN---------LKFPPLFTQKYPCEYVMVQDMLSPSPMERPEA 1068

  Fly   892 ----EELLISDLVPPAQ 904
                |..:..||..|.:
Human  1069 INIIENAVFEDLDFPGK 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD	17..130	CDD:214735
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914	47/281 (17%)
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	152/536 (28%)
		S_TKc	525..895	CDD:214567	149/514 (29%)
		HisS	974..1414	CDD:223202
		class_II_aaRS-like_core	974..>1137	CDD:294192
EIF2AK3	NP_004827.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..101
		Luminal_EIF2AK3	104..420	CDD:188874	51/293 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..571		2/20 (10%)
		PKc_like	587..>663	CDD:304357	37/77 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	841..863		5/21 (24%)
		STKc_EIF2AK3_PERK	<873..1075	CDD:270950	79/229 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1090..1116
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920