DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn2 and HTS1

DIOPT Version :9

Sequence 1:	NP_001263142.1	Gene:	Gcn2 / 43709	FlyBaseID:	FBgn0019990	Length:	1591	Species:	Drosophila melanogaster
Sequence 2:	NP_015358.1	Gene:	HTS1 / 856145	SGDID:	S000006237	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	538	Identity:	128/538 - (23%)
Similarity:	212/538 - (39%)	Gaps:	114/538 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   948 LGSSRAMKSWNSAIIIDDIVSLNPVIEFVKAKVVNLFRKHGAIEVDSPLLSPLSARNSTANANAN 1012
            |.:.:..|.|..:    |:|    :.|.:.:.:..||:|||.:.:|:|:.............::.
Yeast    55 LKTPKGTKDWADS----DMV----IREAIFSTLSGLFKKHGGVTIDTPVFELREILAGKYGEDSK 111

  Fly  1013 AVH-LMTHSGCVVVLPCDLRTQFARHVTMNSVNLIRRYCVDRVYREER--VFNFHPKQSYDCSFD 1074
            .:: |....|.:..|..||...|||:|.||::..|:||.:.:|||.::  :.....::.|.|.||
Yeast   112 LIYNLEDQGGELCSLRYDLTVPFARYVAMNNIQSIKRYHIAKVYRRDQPAMTKGRMREFYQCDFD 176

  Fly  1075 IIAPTTGSHLVDAELLSLAFE-ITSELPRLREKNLAIRMNHTNLLRAILIFCNVP-------KAQ 1131
             :|.|..|.:.|:|.||:..| :||    |..|:..|::||..:|..|.....|.       .:.
Yeast   177 -VAGTFESMVPDSECLSILVEGLTS----LGIKDFKIKLNHRKILDGIFQIAGVKDEDVRKISSA 236

  Fly  1132 YGALFEGTMDFIESRISRFQFHSSIT----GIMEKSRTSAQTLMDMLLANFLLTG---SRSTVDD 1189
            ...|.:...:.::..::..:..|..|    |...|...|.:.:..:|.|:..:|.   ::..:||
Yeast   237 VDKLDKSPWEAVKKEMTEEKGQSEETADKIGEYVKLNGSLKEIHAVLSADANITSNEKAKQGLDD 301

  Fly  1190 SALKSLMRGKGEA----------ASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASN 1244
            .|  :||: ..||          .|||||    |:...||.|.:                  .::
Yeast   302 IA--TLMK-YTEAFDIDSFISFDLSLARG----LDYYTGLIYEV------------------VTS 341

  Fly  1245 GGIVWQMTADLKPNRSGHPSV--------LAIGERYDSMLHEFQKQAQKFNPAMPARGVLSGAGL 1301
            .....:..::||.........        :|.|.|||::::.|.:.:.|.:..:|..|:..|...
Yeast   342 ASAPPENASELKKKAKSAEDASEFVGVGSIAAGGRYDNLVNMFSEASGKKSTQIPCVGISFGVER 406

  Fly  1302 TFSLDK----------------LVAAVGVEYAKDCRAIDVGICVCGTRPPLKDVTYIMRLLWSVG 1350
            .|||.|                .|.|.|  ..||.         .|..|....||   :.||..|
Yeast   407 IFSLIKQRINSSTTIKPTATQVFVMAFG--GGKDW---------TGYLPERMKVT---KQLWDAG 457

  Fly  1351 IRCGIVEAASELGDEAQDLARLGALH--VILVAE---NGSLRVRSFERERFQE--RHLTRTELVE 1408
            |....|..|.....:..|.|.....|  |||..|   .|.|||:...:|...:  ..::..::|.
Yeast   458 IEAEYVYKAKANPRKQFDAAEKAGCHIAVILGKEEYLEGKLRVKRLGQEFADDDGELVSAADIVP 522

  Fly  1409 FIQKML---RSDGLNGTT 1423
            .:|:.|   ..||||..|
Yeast   523 IVQEKLSQIHEDGLNEVT 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD	17..130	CDD:214735
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948
		S_TKc	525..895	CDD:214567
		HisS	974..1414	CDD:223202	117/498 (23%)
		class_II_aaRS-like_core	974..>1137	CDD:294192	48/173 (28%)
HTS1	NP_015358.1	PLN02972	<56..503	CDD:215525	118/498 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810