Protein Alignment Gcn2 and eif2ak2

DIOPT Version :9

• Sequence 1: NP_001263142.1
• Gene: Gcn2 / 43709
• FlyBaseID: FBgn0019990
• Length: 1591
• Species: Drosophila melanogaster
• Sequence 2: NP_001072537.1
• Gene: eif2ak2 / 779992
• XenbaseID: XB-GENE-1001011
• Length: 552
• Species: Xenopus tropicalis
• Alignment Length: 664
• Identity: 169/664 - (25%)
• Similarity: 250/664 - (37%)
• Gaps: 185/664 - (27%)

  Fly   281 QLEQPCIGGGKCHWSSESKCMG-SHR---VDEVMASIEKQVSSLSQLQHK------NLVSYECVL 335
            ||...||..|..:..:|.:..| ||.   ..:|..:.||    |.:.|.|      |:.:...:|
 Frog     9 QLITFCIKNGLAYHFNEVEATGPSHDPRFTSQVFVNQEK----LGEGQDKKKKGAENIAAKMALL 69

  Fly   336 CIKRKEGLLVYLVQD----------FLLGTSVFSISSSLGWCMDGARMVARGVLDALVFLHNKGV 390
            .:|.:|..:....|.          ||...|...:.::.....:|......|.|..|
 Frog    70 TLKERENSVAAAEQSTSEQDSSSIVFLASNSENPVPATSTEMENGCEGNYVGKLHEL-------- 126

  Fly   391 SHSHLLDTTVFMDNTGNVRVSDF--SLVPNLLELLSGAGQSSSCGDLPALGALVESLMPTNSYEM 453
            ...|.|....|.:..|...:.:|  .:|....|.....|.:.......|....:.||.....|::
 Frog   127 CQKHKLICKFFDECYGLPHIPEFWCKVVIGEEEFHKVKGNNKKEAKRKAAYFALMSLKSKYPYDI 191

  Fly   454 R----------DFVDKCNSDRTLSASELLEHPFLRFYVDNG-----QQQVMPLPQQQHPNTVQRT 503
            :          ..::..:...:.||:..||        |.|     .::.:|.|....|....||
 Frog   192 QISDLGVYTEDSKLENSSESPSESAANSLE--------DKGPKNGTTKEAVPHPSNATPTLPLRT 248

  Fly   504 GS-AMPYQIPT------LALSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPAR 561
            .. .:..:.|.      ..|.::.|| .|..:..||.|.||.|||.:..|.|:.|||||:
 Frog   249 RKYELAVKFPNQEKGAQCTLDETFLR-NFTEISRLGSGGFGTVLKAKCKLANKYYAIKRV----- 307

  Fly   562 SRQLYKKMTREVELLSRLNHENVVRYFNSWIESVDDADAAEMDKLLGGEWSQSQQDLSVKPAKSP 626
              :||.|..:|||.|:.|:|.|:|||.:||.                ||...|:...|
 Frog   308 --KLYDKCVKEVEALAHLDHPNIVRYNHSWT----------------GEDCCSESTYS------- 347

  Fly   627 QLGPTLEEDEDEEDSSSSMWNGYIPNMEDSDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSPKP 691
                       ..|.|||      |..:|
 Frog   348 -----------NSDFSSS------PGSKD------------------------------------ 359

  Fly   692 LMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRL--FREIAEGLAHIHQQGIIHRDLKPVNIFL 754
              ..::||||:|||.||::.|..  .|..::...|  ||:|.||:.:||.:|:|||||||.|||.
 Frog   360 --DYLFIQMEWCEKGTLKSWIKH--MNKVEKFKSLVIFRQIIEGVRYIHSKGLIHRDLKPANIFF 420

  Fly   755 DSHDQIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKV---GTTLYVAPELTGNASK 816
            ....:||||||||.|                 |:|...|.....:.   ||..|:|||    ..:
 Frog   421 AEDMKIKIGDFGLVT-----------------QMTGEADRQALERTKGRGTKPYMAPE----QYE 464

  Fly   817 SVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKD-PKYEKTVKMLQWL 880
            ..|..:||::.||:||.|:.. .|.|..|:.:....|||.  .:|.|.::. |..|..:|.   :
 Frog   465 ETYESEVDIFPLGLILVELFY-IFKTVHEKQEEWKKLRNG--ELPPAFVQQYPTEESIIKK---I 523

  Fly   881 LNHDPAQRPTAEEL 894
            |:.|..:||||.:|
 Frog   524 LSRDRKKRPTAAQL 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD	17..130	CDD:214735
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914	43/226 (19%)
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	117/383 (31%)
		S_TKc	525..895	CDD:214567	115/376 (31%)
		HisS	974..1414	CDD:223202
		class_II_aaRS-like_core	974..>1137	CDD:294192
eif2ak2	NP_001072537.1	DSRM_RNAse_III_family	5..71	CDD:380682	17/65 (26%)
		DSRM_EIF2AK2-like	118..183	CDD:380704	12/72 (17%)
		PKc_like	269..541	CDD:389743	117/384 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920