DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gcn2 and Hars2

DIOPT Version :10

Sequence 1:NP_001263142.1 Gene:Gcn2 / 43709 FlyBaseID:FBgn0019990 Length:1591 Species:Drosophila melanogaster
Sequence 2:NP_542367.1 Gene:Hars2 / 70791 MGIID:1918041 Length:505 Species:Mus musculus


Alignment Length:508 Identity:113/508 - (22%)
Similarity:195/508 - (38%) Gaps:132/508 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   969 LNP----VIEFVKAKVVNLFRKHGAIEVDSPLLSPLSARNSTANANANAVH-LMTHSGCVVVLPC 1028
            |:|    |.|.:..|:::.|::|||..:|:|..............|...:: |....|.::.|..
Mouse    65 LSPQQMVVREKILDKIISCFKRHGAKGLDTPAFELKEMLTEKYEDNFGLMYDLKDQGGELLSLRY 129

  Fly  1029 DLRTQFARHVTMNSVNLIRRYCVDRVYREE--RVFNFHPKQSYDCSFDIIAPTTGSHLVDAELLS 1091
            ||...|||::.||.:..::||.|.:|:|.|  .:.....::...|.|| ||......:.|||.|.
Mouse   130 DLTVPFARYLAMNKLKKMKRYQVGKVWRRESPAIAQGRYREFCQCDFD-IAGEFDPMIPDAECLR 193

  Fly  1092 LAFEITSELPRLREKNLAIRMNHTNLLRAILIFCNVPKAQYGALF-------------------- 1136
            :..||   |..|:..:..|::|...::..|...|.||:::...:.                    
Mouse   194 IMCEI---LSGLQLGDFLIKVNDRRVVDGIFAVCGVPESKLRTICSSMDKLDKMSWEGVRHEMVA 255

  Fly  1137 -EGTMDFIESRISRF-QFHSSITGI--------MEKSRTSAQTLMDM-LLANFL-LTGSRSTVDD 1189
             :|....:..||..| |:|..|:.:        :.:|:.:.|.|.|: ||..:| |.|    :.|
Mouse   256 KKGLAPEVADRIGDFVQYHGGISLVEDLFKDPRLSQSQLALQGLGDLKLLFEYLRLFG----IAD 316

  Fly  1190 SALKSLMRGKGEAASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASNGGIVWQMTAD 1254
            .....|        ||||          ||.|..||                      :::....
Mouse   317 KISLDL--------SLAR----------GLDYYTGV----------------------IYEAVLL 341

  Fly  1255 LKPNRSGHPSV----LAIGERYDSMLHEFQKQAQKFNPAMPARGVLSGAGLTFSLDKLVAAVGVE 1315
            ..|.::|..::    :|.|.|||:::.:|..:...    :|..|:..|....|.|.:....:..|
Mouse   342 ESPAQAGKETLSVGSVAAGGRYDNLVAQFDPKGHH----VPCVGLSIGVERIFYLVEQKMKMSGE 402

  Fly  1316 YAKDCRAIDVGICVCGTRPP-LKDVTYIMRLLWSVGIRCGIVEAASELGDEAQDLAR-----LGA 1374
               ..|..:..:.|...:.. |::...|:..||..||:             |:.|.:     |..
Mouse   403 ---KVRTTETQVFVATPQKNFLQERLKIIAELWDAGIK-------------AEMLYKNNPKLLTQ 451

  Fly  1375 LH---------VILVAE----NGSLRVRSFERERFQERHLTRTELVEFIQKML 1414
            ||         ::::.|    .|.:::||....  :|..:.|..||..|||.|
Mouse   452 LHYCEKADIPLMVIIGEQERNEGVIKLRSVASR--EEVTINRESLVAEIQKRL 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gcn2NP_001263142.1 RWD_GCN2 11..131 CDD:467659
PK_eIF2AK_GCN2_rpt1 261..476 CDD:270914
STKc_EIF2AK4_GCN2_rpt2 518..898 CDD:270948
class_II_aaRS-like_core 974..>1137 CDD:444800 44/186 (24%)
PRK12420 1029..1392 CDD:237097 90/419 (21%)
Hars2NP_542367.1 PLN02972 <57..503 CDD:215525 113/508 (22%)
Blue background indicates that the domain is not in the aligned region.

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