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Protein Alignment Gcn2 and Hars2

DIOPT Version :9

Sequence 1:	NP_001263142.1	Gene:	Gcn2 / 43709	FlyBaseID:	FBgn0019990	Length:	1591	Species:	Drosophila melanogaster
Sequence 2:	NP_542367.1	Gene:	Hars2 / 70791	MGIID:	1918041	Length:	505	Species:	Mus musculus

Alignment Length:	508	Identity:	113/508 - (22%)
Similarity:	195/508 - (38%)	Gaps:	132/508 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   969 LNP----VIEFVKAKVVNLFRKHGAIEVDSPLLSPLSARNSTANANANAVH-LMTHSGCVVVLPC 1028
            |:|    |.|.:..|:::.|::|||..:|:|..............|...:: |....|.::.|..
Mouse    65 LSPQQMVVREKILDKIISCFKRHGAKGLDTPAFELKEMLTEKYEDNFGLMYDLKDQGGELLSLRY 129

  Fly  1029 DLRTQFARHVTMNSVNLIRRYCVDRVYREE--RVFNFHPKQSYDCSFDIIAPTTGSHLVDAELLS 1091
            ||...|||::.||.:..::||.|.:|:|.|  .:.....::...|.|| ||......:.|||.|.
Mouse   130 DLTVPFARYLAMNKLKKMKRYQVGKVWRRESPAIAQGRYREFCQCDFD-IAGEFDPMIPDAECLR 193

  Fly  1092 LAFEITSELPRLREKNLAIRMNHTNLLRAILIFCNVPKAQYGALF-------------------- 1136
            :..||   |..|:..:..|::|...::..|...|.||:::...:.
Mouse   194 IMCEI---LSGLQLGDFLIKVNDRRVVDGIFAVCGVPESKLRTICSSMDKLDKMSWEGVRHEMVA 255

  Fly  1137 -EGTMDFIESRISRF-QFHSSITGI--------MEKSRTSAQTLMDM-LLANFL-LTGSRSTVDD 1189
             :|....:..||..| |:|..|:.:        :.:|:.:.|.|.|: ||..:| |.|    :.|
Mouse   256 KKGLAPEVADRIGDFVQYHGGISLVEDLFKDPRLSQSQLALQGLGDLKLLFEYLRLFG----IAD 316

  Fly  1190 SALKSLMRGKGEAASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASNGGIVWQMTAD 1254
            .....|        ||||          ||.|..||                      :::....
Mouse   317 KISLDL--------SLAR----------GLDYYTGV----------------------IYEAVLL 341

  Fly  1255 LKPNRSGHPSV----LAIGERYDSMLHEFQKQAQKFNPAMPARGVLSGAGLTFSLDKLVAAVGVE 1315
            ..|.::|..::    :|.|.|||:::.:|..:...    :|..|:..|....|.|.:....:..|
Mouse   342 ESPAQAGKETLSVGSVAAGGRYDNLVAQFDPKGHH----VPCVGLSIGVERIFYLVEQKMKMSGE 402

  Fly  1316 YAKDCRAIDVGICVCGTRPP-LKDVTYIMRLLWSVGIRCGIVEAASELGDEAQDLAR-----LGA 1374
               ..|..:..:.|...:.. |::...|:..||..||:             |:.|.:     |..
Mouse   403 ---KVRTTETQVFVATPQKNFLQERLKIIAELWDAGIK-------------AEMLYKNNPKLLTQ 451

  Fly  1375 LH---------VILVAE----NGSLRVRSFERERFQERHLTRTELVEFIQKML 1414
            ||         ::::.|    .|.:::||....  :|..:.|..||..|||.|
Mouse   452 LHYCEKADIPLMVIIGEQERNEGVIKLRSVASR--EEVTINRESLVAEIQKRL 502

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.