DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gcn2 and eif2ak1

DIOPT Version :9

Sequence 1:	NP_001263142.1	Gene:	Gcn2 / 43709	FlyBaseID:	FBgn0019990	Length:	1591	Species:	Drosophila melanogaster
Sequence 2:	XP_021335808.1	Gene:	eif2ak1 / 565338	ZFINID:	ZDB-GENE-061013-268	Length:	667	Species:	Danio rerio

Alignment Length:	652	Identity:	176/652 - (26%)
Similarity:	276/652 - (42%)	Gaps:	204/652 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 VSDF-SLVPNLLELLSGAGQSSSCGDLPALGALVESLM------PTNSYEMRDFVDKCNSDRTLS 467
            :.:| |.:||.|                .||:|:|.|.      ||.|..:...:     .:.|:
Zfish    81 IQEFASAIPNQL----------------LLGSLLEHLCFVYESDPTRSRMLFKVI-----GQRLA 124

  Fly   468 ASELL-------EHPFLRFYVDNGQQQVM-----PLPQQQH-----PNTVQRTGSAMPYQIPTLA 515
            |..||       |...:|...:....:::     .|..|:|     ....:||...: :|..|
Zfish   125 AMNLLSPLAISDEFSTVRLQHNRAFTELLHATSSSLFPQEHKYLSTEGQSKRTKDGL-FQAQT-- 186

  Fly   516 LSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLN 580
               ||..:|||.:..||||::|.|.:|.|.||.:|||:|:|.:...:|....|:.|||::||.|.
Zfish   187 ---SRYLSEFEEIATLGKGSYGKVFRVTNKLDGQEYAVKKILIKKVTRDDCMKVLREVKVLSSLQ 248

  Fly   581 HENVVRYFNSWIESVDDADAAEMDKLLG-----------------------------------GE 610
            |.|:|.|..:|:|.|..| ..:.:.|:.                                   .|
Zfish   249 HPNIVGYHTAWMEHVQPA-VTDSNSLVSQTFPALDRPSEPNGCTPEHTNSSNGSFIVFEHSERAE 312

  Fly   611 WSQSQ---QDLSVKPAKS---------------PQ-------LG----------------PTLEE 634
            ..::|   :.:||.|:.|               ||       ||                .||.|
Zfish   313 VKENQVALESISVNPSTSKVDMAQSVCPKNVRKPQNFVPCVFLGKPRSTLNKCPAANWDSSTLSE 377

  Fly   635 DEDEEDSSSSMWNGYIPNMEDSDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSPKPLMQVMYIQ 699
            |:..::......:.||      |.|..|:           .|:||:..:        ...::|||
Zfish   378 DDLSQNRLELNKHSYI------DMDTPEW-----------SEKQENKVQ--------FHLMLYIQ 417

  Fly   700 MEFCEKCTLRTAIDDNLFNDTDRL---------------WRLFREIAEGLAHIHQQGIIHRDLKP 749
            |:.||: :|:..|.:.....|:.|               .::.::|.||:.:||..||:||||||
Zfish   418 MQLCER-SLKDWIQERNSRTTEGLLMSGDPCDSVDCEQALKILKKILEGVEYIHSCGIMHRDLKP 481

  Fly   750 VNIFLDSHD-QIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKVGTTLYVAPE-LTG 812
            .||||..:: .:||||||||..:.: :..|:..|:. :|.....|.|.|..|||.:|.||| |.|
Zfish   482 RNIFLLGNECHVKIGDFGLACQNII-MDEHEKLPSS-SQAGVNPDATHTSGVGTFVYAAPEQLEG 544

  Fly   813 NASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKD-PKYEKTVKM 876
                |.|:.|.|||::|:|.||:.| ||.|.|||..|:..||..  .||:.:..: |...|.:|:
Zfish   545 ----SRYDSKSDMYSIGVIAFELFQ-PFGTEMERVHTLGELRQG--KIPNTLSTNWPILAKYIKL 602

  Fly   877 LQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQEMLRHALANPQSKAYKNLVARCLQQESDEV 941
               |.:.||:.||:|.:||.|||.        ...:|:.|:|            .|.:.::.:|:
Zfish   603 ---LTSSDPSMRPSAPQLLQSDLF--------STNDMVIHSL------------KRKIDEQEEEI 644

  Fly   942 LE 943
            ::
Zfish   645 VQ 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD	17..130	CDD:214735
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914	18/79 (23%)
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	142/473 (30%)
		S_TKc	525..895	CDD:214567	137/463 (30%)
		HisS	974..1414	CDD:223202
		class_II_aaRS-like_core	974..>1137	CDD:294192
eif2ak1	XP_021335808.1	STKc_EIF2AK1_HRI	186..620	CDD:270951	143/477 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920