Protein Alignment Gcn2 and eif2ak3

DIOPT Version :10

• Sequence 1: NP_001263142.1
• Gene: Gcn2 / 43709
• FlyBaseID: FBgn0019990
• Length: 1591
• Species: Drosophila melanogaster
• Sequence 2: XP_005156642.3
• Gene: eif2ak3 / 559564
• ZFINID: ZDB-GENE-050414-2
• Length: 1099
• Species: Danio rerio
• Alignment Length: 829
• Identity: 198/829 - (23%)
• Similarity: 313/829 - (37%)
• Gaps: 300/829 - (36%)

  Fly   312 SIEKQVSSLSQLQHKNLVSYECVLCIKRKEGLLVYLVQDFLLGTSVFSISSSLGWCMDGARMV-- 374
            |...||..|..:...::..::.:....:.||.|::..|        |....:..|.:.|.::.
Zfish   313 SAHTQVEGLDLVIKVSVPDWKVMAFSTKPEGQLIWEHQ--------FCTPIASAWLVGGGKVTPI 369

  Fly   375 -------------------------ARGVLDALVFLHNKGVSHSHLLDTTVFMDNTGNVRVSDFS 414
                                     |||..::.|:|   |:....|     ::.:  :||:|:
Zfish   370 SLFDDTSYNSQTETETQEDDDIMEEARGATESSVYL---GMFQGQL-----YLQS--SVRISE-- 422

  Fly   415 LVPNLLELLSGAGQSSSCGDLPALGALVESLMPTNSYEMRDFV---------------DKC-NSD 463
            ..|:..:.|:|.|     ||        ..:||..:.:.:..:               ||| |:|
Zfish   423 KFPSKSKALNGWG-----GD--------TDMMPPPTVKWKPLIHSPSRTPVLVGSEEFDKCLNND 474

  Fly   464 R------TLSASELLEHPFLRFYVDNG---------------------------------QQQVM 489
            :      :..|..:|::|:     |||                                 :..|:
Zfish   475 KFSHEEYSNGALSILQYPY-----DNGYYFPYSPRYRNRRDETAVSVLLKKDGEGSQVRRKDPVL 534

  Fly   490 PLPQQQ---------------------HPNTV---QRTGSAMPYQIPTLALSQ------------ 518
            .||..:                     ||.|.   ||..|....|..|...:.
Zfish   535 LLPWWKEILGTIFFCIAATTYIVRKFFHPPTTYSRQRKESETQCQTDTKFEADVTEPKEVVVTDM 599

  Fly   519 ------SRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYK-KMTREVELL 576
                  ||..|:||.:..||:|.||.|.:.||.:|:..||||||.||  :|:|.: |:.|||:.|
Zfish   600 RPCEYVSRYLTDFEPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRLP--NRELAREKVMREVKAL 662

  Fly   577 SRLNHENVVRYFNSWIESVDDADAAEMDK-----LLGGEWSQSQQD----LSVK-PAKSPQ---- 627
            ::|.|..::||||:|.||.......:|||     ....:|..|..:    .||| |..:|.
Zfish   663 AKLEHPGIIRYFNAWQESPPQGWQEDMDKRWLKDASTADWLLSSPEHMEAFSVKVPVATPSPVDS 727

  Fly   628 ----------------------LGP--TLEEDEDEEDSSSSMWNGYIPNMED------------- 655
                                  |||  .:.|.:.:.|..:.|.....|:..:
Zfish   728 SCMCAAGGDTSVCVGDQVCVEGLGPDSMMSERDSQADPDAIMEVSDSPHSFELCPPRTVAHGDCT 792

  Fly   656 SDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSP------------------------------- 689
            |.|..|.|.||.     .:.::.:....|.|..|
Zfish   793 SSSFDIVFEDSG-----CEHQDNDSDLSGSTPVPPVCLSQSGSKPQRSTSTGPPISLPSRPTTLS 852

  Fly   690 ----------KPLMQ---VMYIQMEFCEKCTLRTAIDDNL---FNDTDRLWRLFREIAEGLAHIH 738
                      :||:.   .:||||:.|.|..|:..:....   ..:..:...:|.:|||.:..:|
Zfish   853 LAPSTPCPVVRPLLTPKVYLYIQMQLCRKENLKDWMAQRCLPELREHTQCLDIFLQIAEAVDFLH 917

  Fly   739 QQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHD------AAPAPVNQITSAEDGTGT 797
            .:|::||||||.|||....|.:|:|||||.|...   |..|      ..|.|:.       ...|
Zfish   918 SKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMD---QEEDDEELSTLTPMPIY-------ARHT 972

  Fly   798 GKVGTTLYVAPE-LTGNASKSVYNQKVDMYTLGIILFE-MCQPPFDTSMERAQTIMALRNVSINI 860
            |:|||.||::|| |:||:    |:.|||:|:||:|||| :|  ||.|.|||.:|:..:|  ::..
Zfish   973 GQVGTKLYMSPEQLSGNS----YSHKVDIYSLGLILFELLC--PFRTQMERVRTLTEVR--ALQF 1029

  Fly   861 PDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEEL----LISDLVPPAQL 905
            |.|..|....|  .:|::.:|:..||:||.|.|:    |..:|..|.::
Zfish  1030 PAAFCKANILE--AQMVRCMLSRVPAERPEASEITEAPLFQELEVPCRI 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD_GCN2	11..131	CDD:467659
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914	36/212 (17%)
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	145/508 (29%)
		class_II_aaRS-like_core	974..>1137	CDD:444800
		PRK12420	1029..1392	CDD:237097
eif2ak3	XP_005156642.3	None