DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gcn2 and eif2ak3

DIOPT Version :9

Sequence 1:	NP_001263142.1	Gene:	Gcn2 / 43709	FlyBaseID:	FBgn0019990	Length:	1591	Species:	Drosophila melanogaster
Sequence 2:	XP_005156642.2	Gene:	eif2ak3 / 559564	ZFINID:	ZDB-GENE-050414-2	Length:	1099	Species:	Danio rerio

Alignment Length:	829	Identity:	198/829 - (23%)
Similarity:	313/829 - (37%)	Gaps:	300/829 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 SIEKQVSSLSQLQHKNLVSYECVLCIKRKEGLLVYLVQDFLLGTSVFSISSSLGWCMDGARMV-- 374
            |...||..|..:...::..::.:....:.||.|::..|        |....:..|.:.|.::.
Zfish   313 SAHTQVEGLDLVIKVSVPDWKVMAFSTKPEGQLIWEHQ--------FCTPIASAWLVGGGKVTPI 369

  Fly   375 -------------------------ARGVLDALVFLHNKGVSHSHLLDTTVFMDNTGNVRVSDFS 414
                                     |||..::.|:|   |:....|     ::.:  :||:|:
Zfish   370 SLFDDTSYNSQTETETQEDDDIMEEARGATESSVYL---GMFQGQL-----YLQS--SVRISE-- 422

  Fly   415 LVPNLLELLSGAGQSSSCGDLPALGALVESLMPTNSYEMRDFV---------------DKC-NSD 463
            ..|:..:.|:|.|     ||        ..:||..:.:.:..:               ||| |:|
Zfish   423 KFPSKSKALNGWG-----GD--------TDMMPPPTVKWKPLIHSPSRTPVLVGSEEFDKCLNND 474

  Fly   464 R------TLSASELLEHPFLRFYVDNG---------------------------------QQQVM 489
            :      :..|..:|::|:     |||                                 :..|:
Zfish   475 KFSHEEYSNGALSILQYPY-----DNGYYFPYSPRYRNRRDETAVSVLLKKDGEGSQVRRKDPVL 534

  Fly   490 PLPQQQ---------------------HPNTV---QRTGSAMPYQIPTLALSQ------------ 518
            .||..:                     ||.|.   ||..|....|..|...:.
Zfish   535 LLPWWKEILGTIFFCIAATTYIVRKFFHPPTTYSRQRKESETQCQTDTKFEADVTEPKEVVVTDM 599

  Fly   519 ------SRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYK-KMTREVELL 576
                  ||..|:||.:..||:|.||.|.:.||.:|:..||||||.||  :|:|.: |:.|||:.|
Zfish   600 RPCEYVSRYLTDFEPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRLP--NRELAREKVMREVKAL 662

  Fly   577 SRLNHENVVRYFNSWIESVDDADAAEMDK-----LLGGEWSQSQQD----LSVK-PAKSPQ---- 627
            ::|.|..::||||:|.||.......:|||     ....:|..|..:    .||| |..:|.
Zfish   663 AKLEHPGIIRYFNAWQESPPQGWQEDMDKRWLKDASTADWLLSSPEHMEAFSVKVPVATPSPVDS 727

  Fly   628 ----------------------LGP--TLEEDEDEEDSSSSMWNGYIPNMED------------- 655
                                  |||  .:.|.:.:.|..:.|.....|:..:
Zfish   728 SCMCAAGGDTSVCVGDQVCVEGLGPDSMMSERDSQADPDAIMEVSDSPHSFELCPPRTVAHGDCT 792

  Fly   656 SDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSP------------------------------- 689
            |.|..|.|.||.     .:.::.:....|.|..|
Zfish   793 SSSFDIVFEDSG-----CEHQDNDSDLSGSTPVPPVCLSQSGSKPQRSTSTGPPISLPSRPTTLS 852

  Fly   690 ----------KPLMQ---VMYIQMEFCEKCTLRTAIDDNL---FNDTDRLWRLFREIAEGLAHIH 738
                      :||:.   .:||||:.|.|..|:..:....   ..:..:...:|.:|||.:..:|
Zfish   853 LAPSTPCPAVRPLLTPKVYLYIQMQLCRKENLKDWMAQRCLPELREHTQCLDIFLQIAEAVDFLH 917

  Fly   739 QQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHD------AAPAPVNQITSAEDGTGT 797
            .:|::||||||.|||....|.:|:|||||.|...   |..|      ..|.|:.       ...|
Zfish   918 SKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMD---QEEDDEELSTLTPMPIY-------ARHT 972

  Fly   798 GKVGTTLYVAPE-LTGNASKSVYNQKVDMYTLGIILFE-MCQPPFDTSMERAQTIMALRNVSINI 860
            |:|||.||::|| |:||:    |:.|||:|:||:|||| :|  ||.|.|||.:|:..:|  ::..
Zfish   973 GQVGTKLYMSPEQLSGNS----YSHKVDIYSLGLILFELLC--PFRTQMERVRTLTEVR--ALQF 1029

  Fly   861 PDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEEL----LISDLVPPAQL 905
            |.|..|....|  .:|::.:|:..||:||.|.|:    |..:|..|.::
Zfish  1030 PAAFCKANILE--AQMVRCMLSRVPAERPEASEITEAPLFQELEVPCRI 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD	17..130	CDD:214735
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914	36/212 (17%)
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	145/508 (29%)
		S_TKc	525..895	CDD:214567	141/480 (29%)
		HisS	974..1414	CDD:223202
		class_II_aaRS-like_core	974..>1137	CDD:294192
eif2ak3	XP_005156642.2	Luminal_EIF2AK3	100..437	CDD:188874	25/148 (17%)
eif2ak3	XP_005156642.2	STKc_EIF2AK3_PERK	606..1063	CDD:270950	144/483 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920