DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gcn2 and Eif2ak2

DIOPT Version :9

Sequence 1:	NP_001263142.1	Gene:	Gcn2 / 43709	FlyBaseID:	FBgn0019990	Length:	1591	Species:	Drosophila melanogaster
Sequence 2:	NP_062208.2	Gene:	Eif2ak2 / 54287	RGDID:	3402	Length:	513	Species:	Rattus norvegicus

Alignment Length:	382	Identity:	113/382 - (29%)
Similarity:	163/382 - (42%)	Gaps:	123/382 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 RLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENV 584
            |...:||.:..:|.|.||.|.|.::.:|.:.||||||....      ||..|||:.|:.|||.|:
  Rat   231 RFSKDFEDIEEIGSGGFGQVFKAKHRIDGKTYAIKRITYNT------KKAKREVQALAELNHANI 289

  Fly   585 VRYFNSWIESVDDADAAEMDKLLGGEWSQSQQDLSVKPAKSPQLGPTLEEDEDEEDSSSSMWNGY 649
            |:|...|                                          |.||.
  Rat   290 VQYRVCW------------------------------------------EGEDY----------- 301

  Fly   650 IPNMEDSDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSPKPLMQVMYIQMEFCEKCTLRTAIDD 714
                                     |.:.|:||.|.|:..|  .:.::||||||:|.||:..::.
  Rat   302 -------------------------DYDPENSTNGDTSRYK--TRCLFIQMEFCDKGTLQQWLEK 339

  Fly   715 NLFNDTDR--LWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQA 777
            ...:..|:  :..||.:|..|:.:||.:|:|||||||.||||.....||||||||||    ||:
  Rat   340 RNRSQEDKALVLELFEQIVTGVDYIHSKGLIHRDLKPGNIFLVDEKHIKIGDFGLAT----ALE- 399

  Fly   778 HDAAPAPVNQITSAEDGTGTGKVGTTLYVAPELTGNASKSVYNQKVDMYTLGIILFEM---CQPP 839
            :|..|.             |...||..|::||  ..:|...|.::||::.||:||.|:   |:
  Rat   400 NDGNPR-------------TKYTGTPQYMSPE--QKSSLVEYGKEVDIFALGLILAELLHICK-- 447

  Fly   840 FDTSMERAQTIMALRNVSINIPDAMLKDPKYE-KTVKMLQWLLNHDPAQRPTAEELL 895
              |..|:.:....|||       .:..|..:: |...:||.||:..|.:||...|:|
  Rat   448 --TDSEKIEFFQLLRN-------GVFSDDIFDNKEKSLLQKLLSSKPRERPNTSEIL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD	17..130	CDD:214735
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	113/382 (30%)
		S_TKc	525..895	CDD:214567	111/375 (30%)
		HisS	974..1414	CDD:223202
		class_II_aaRS-like_core	974..>1137	CDD:294192
Eif2ak2	NP_062208.2	DSRM_EIF2AK2_rpt1	7..74	CDD:380732
		DSRM_EIF2AK2_rpt2	94..160	CDD:380733
		PKc_like	229..498	CDD:419665	113/382 (30%)
		Interaction with TRAF5. /evidence=ECO:0000250\|UniProtKB:P19525	235..513		112/378 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920