Protein Alignment Gcn2 and PEK

DIOPT Version :10

• Sequence 1: NP_001263142.1
• Gene: Gcn2 / 43709
• FlyBaseID: FBgn0019990
• Length: 1591
• Species: Drosophila melanogaster
• Sequence 2: NP_649538.1
• Gene: PEK / 40653
• FlyBaseID: FBgn0037327
• Length: 1162
• Species: Drosophila melanogaster
• Alignment Length: 1173
• Identity: 254/1173 - (21%)
• Similarity: 415/1173 - (35%)
• Gaps: 412/1173 - (35%)

  Fly    67 KLHVTCPSKYPKLPPKIS---------------------LEESKGMSDQLLEALRNQLQAQSQEL 110
            :|.:|...::.::.|.:|                     |..|...||.|:.:...:.::....:
  Fly   113 RLELTNNGQFVRMIPSLSGGIYKFDGDSIDPIPITAEHLLSSSAKFSDDLVISGGKETRSYGVSV 177

  Fly   111 RGEVMIYELAQTVQAFLLEHNKPPKGSFYDQMLQDKQKRDQELQDIQRQRES----LQRQTLIDE 171
            |...::||.:.....     |...:|...|..:::..:.|| |:|.::.|:.    ::...|:|:
  Fly   178 RTGQLLYECSLNGCV-----NSTEEGLAIDDTIREPDEEDQ-LEDGEQLRDEAGYIVRHDPLLDD 236

  Fly   172 ---VERRKEMFKTEAKRRGEPRRSMSESNPRHPSSSESSENSSPYYRGHIYPSKC-LDHRNTETL 232
               |.|:.:..:....|.|..|.:.|..  :|....             :.||:| |..|:...|
  Fly   237 VIIVRRQTQTVRAVESRTGVERWNFSVG--QHELDL-------------VRPSECQLQPRDELEL 286

  Fly   233 YFHKMGRQ--IQRG--CCVGEGHSQRGCIAYTGIDMHCGQLLY--------ITEWNIKYSQLEQP 285
            ....:..:  :..|  |...:...|              .:|:        ::.||.......||
  Fly   287 AVLDVDIKVVVPEGIICAFSKSEPQ--------------TMLWKYKFDHPIVSAWNTNADDELQP 337

  Fly   286 --CIGGGKCHWSSESKCMGSHRVDEVMASIEKQVSSLSQLQHKNLVSYECVLCIKRKEGLLVYLV 348
              .....:..|..:..       |..:.:..:...|:      .|..|:..|.|:..    :.|.
  Fly   338 IDLFSSAQWLWDQDEN-------DTELPNAPQSPPSI------YLGMYDKQLYIQES----IRLR 385

  Fly   349 QDFLLGTSVF-------SISSSLGW----------------------CMDGA------------- 371
            |:.:..|.|:       |:...:.|                      ..:||
  Fly   386 QEIMDQTKVYQQLTGDTSLMPRIPWKPISASSKSLVIFRKDQEDPEMIAEGAVAQGGELVPYDDE 450

  Fly   372 --RMVARGVLDALVFLHNKGVSHSHLLDTTVFMDNTGNVRVSDFSLVPNLLELLSGAGQSSSCG- 433
              .:.|:.||:|..|::..|          .:...||:               |:|..:.|:..
  Fly   451 NFAVAAQSVLNASEFVNGNG----------FYFYTTGD---------------LNGPQECSTQNN 490

  Fly   434 --DLPAL-------GALVESLMPTNSYEMRDFVDKCNSD----------------RTLSASELLE 473
              ||||:       .|..|....|.::.:.|.:.....|                :.:.......
  Fly   491 PTDLPAITAPTSPTNATSEGTEATGNHSVNDDLGFSLDDIDAPVKVVILSLWFWWKEIVVIAFTS 555

  Fly   474 HPFLRFYVDNGQQQV----------MPLP---QQQHPNTVQRTGSAMPYQIP------------- 512
            ...|..::....|:|          :|:.   :....:|....|..:|.|.|
  Fly   556 AVILNIFMGQRNQRVEREYLVIERHVPVQTAIEATEASTQALLGPVVPMQRPGNRFSFPPGQANQ 620

  Fly   513 -TLALS--------QSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPAR--SRQLY 566
             |::.|        .||.:::||::..||:|.||.|.:.:|.||...||||||.||.:  |||
  Fly   621 RTISESTTHSGEHYTSRFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQ-- 683

  Fly   567 KKMTREVELLSRLNHENVVRYFNSWIESVDDADAAEMD-KLLGGEWSQSQQ----DLSVKPAKSP 626
             ::.||...|:...|.|:||||:||.|:.......|.| |||..|.|.|.|    |.|..|:.:.
  Fly   684 -RVLREARTLASCEHHNIVRYFHSWTETPPTGWQEEEDRKLLAHELSTSIQIETPDDSTMPSLTE 747

  Fly   627 QLGPTLEED-----EDEEDSSSSMWNGYIPNME-----------DSDSDG-IEFVDSNGKVAV-- 672
            ||....::.     .|..:|::...:.::|...           |.:.|. |||...:...|:
  Fly   748 QLKEKRQQQLLSWVSDAANSTACSHDFHLPGESSLKNIREEYDYDEEEDSLIEFRSESQSAALRA 812

  Fly   673 ----------YDDEEQE---------------------------------------DSTRGKTNS 688
                      .:||||:                                       :|.|.|::.
  Fly   813 EEEDDTDDDYEEDEEQQGDHEKRHRSSVSIDIHSASFDLKNINYSQHQLVSNSFQIESVRPKSSG 877

  Fly   689 --------------------------------------------PKPLMQVMYIQMEFCEKCTLR 709
                                                        .||....:||||:.|.|.:||
  Fly   878 SDDANDDNKARRKPLTLALAQNHNNNQNGSQPTPSSATILNGTVAKPSKVYLYIQMQLCRKESLR 942

  Fly   710 TAIDDNLFNDT--DRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSF 772
            ..:.||. ::|  ..:..:|.:|.:.:.::|.:|:|||||||.|||.....|||||||||.|
  Fly   943 DWLRDNR-SETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSNIFFSQDGQIKIGDFGLVT--- 1003

  Fly   773 LALQAHDAAPAPVNQITSAEDGTG-------TGKVGTTLYVAPE-LTGNASKSVYNQKVDMYTLG 829
                  |.|..| |.:....|.:|       |.:|||.||::|| |.|..    |:.|||:|:||
  Fly  1004 ------DMADIP-NLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQH----YDYKVDIYSLG 1057

  Fly   830 IILFEMCQPPFDTSMERAQTIMALR------NVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQR 888
            :|.||: ...|.|.|||.:|:.:||      :.::|.|.      :|:    :||.:|:..|.||
  Fly  1058 LIFFEL-HVYFSTEMERIKTLRSLRDGQYPKDFAVNYPQ------QYD----LLQQMLSAQPEQR 1111

  Fly   889 PTAEELLISDLVPPAQLEANELQEMLRHALANPQSKAYKNLVARCLQQESDEVLEHTYHLGSSRA 953
            |..::|       .:||. |.||  |.|.|:..||             |..|:.|....|..||.
  Fly  1112 PQTKQL-------KSQLR-NILQ--LPHLLSEGQS-------------EQAELAERARRLSRSRT 1153

  Fly   954 MKS 956
            ..|
  Fly  1154 FSS 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD_GCN2	11..131	CDD:467659	12/84 (14%)
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914	40/294 (14%)
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	148/514 (29%)
		class_II_aaRS-like_core	974..>1137	CDD:444800
		PRK12420	1029..1392	CDD:237097
PEK	NP_649538.1	Luminal_EIF2AK3	73..401	CDD:188874	54/339 (16%)
		Protein Kinases, catalytic domain	635..1113	CDD:473864	146/506 (29%)