Protein Alignment Gcn2 and Hars1

DIOPT Version :9

• Sequence 1: NP_001263142.1
• Gene: Gcn2 / 43709
• FlyBaseID: FBgn0019990
• Length: 1591
• Species: Drosophila melanogaster
• Sequence 2: NP_001020585.1
• Gene: Hars1 / 307492
• RGDID: 1310695
• Length: 508
• Species: Rattus norvegicus
• Alignment Length: 568
• Identity: 122/568 - (21%)
• Similarity: 226/568 - (39%)
• Gaps: 139/568 - (24%)

  Fly   910 LQEMLRHALANPQSKAYKNLVARCLQQESDEVLEHTYHLGSSRAMKSWNSAIIIDDIVSLNP--- 971
            |:|::|...|:.:....:...|..:::|..::|:....||.....:.:         |...|
  Rat     7 LEELVRLQGAHVRGLKEQKASAEQIEEEVTKLLKLKAQLGHDEGKQKF---------VLKTPKGT 62

  Fly   972 ---------VIEFVKAKVVNLFRKHGAIEVDSPLLSPLSARNSTANANANAVH-LMTHSGCVVVL 1026
                     |.|.|...::..|::|||..:|:|:.............::..:: |....|.::.|
  Rat    63 RDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLTGKYGEDSKLIYDLKDQGGELLSL 127

  Fly  1027 PCDLRTQFARHVTMNSVNLIRRYCVDRVYREERVFNFHP-------KQSYDCSFDIIAPTTGSHL 1084
            ..||...|||::.||.:..|:||.:.:|||.:     :|       ::.|.|.|| ||......:
  Rat   128 RYDLTVPFARYLAMNKLTNIKRYHIAKVYRRD-----NPAMTRGRYREFYQCDFD-IAGQFDPMI 186

  Fly  1085 VDAELLSLAFEITSELPRLREKNLAIRMNHTNLLRAILIFCNVPKAQYGALF------------- 1136
            .|||.|.:..||.|.   |:..|..:::|...:|..:...|.||.:::..:.
  Rat   187 PDAECLKIMCEILSS---LQIGNFQVKVNDRRILDGMFAVCGVPDSKFRTICSSVDKLDKVSWEE 248

  Fly  1137 --------EGTMDFIESRISRF-QFHSSITGI--------MEKSRTSAQTLMDM-LLANFL-LTG 1182
                    :|....:..||..: |.|..::.:        :.:::.:.:.|.|: ||..:| |.|
  Rat   249 VKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQAVEGLGDLKLLFEYLTLFG 313

  Fly  1183 SRSTVDDSALKSLMRGKGEAASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASNGGI 1247
                :||.....|        |||||    |:...|:.|.                       .:
  Rat   314 ----IDDKISFDL--------SLARG----LDYYTGVIYE-----------------------AV 339

  Fly  1248 VWQMTADLKPNRSGHPSV----LAIGERYDSMLHEFQKQAQKFNPAMPARGVLSGAGLTFSL--D 1306
            :.||     |.::|...:    :|.|.|||.::..|..:.:|    :|..|:..|....||:  .
  Rat   340 LLQM-----PTQAGEEPLGVGSIAAGGRYDGLVGMFDPKGRK----VPCVGLSIGVERIFSIVEQ 395

  Fly  1307 KLVAAVGVEYAKDCRAIDVGICVCGTRPP-LKDVTYIMRLLWSVGIRCGIV-EAASELGDEAQDL 1369
            ||.|:     .:..|..:..:.|...:.. |::...::..||..||:..:: :...:|.::.|..
  Rat   396 KLEAS-----EEKVRTTETQVLVASAQKKLLEERLKLISELWDAGIKAELLYKKNPKLLNQLQYC 455

  Fly  1370 ARLGALHVILVAE----NGSLRVRSF-ERERFQERHLTRTELVEFIQK 1412
            ...|...|.::.|    :|.:::||. .||....|   |.:|||.|::
  Rat   456 EEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVR---REDLVEEIRR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD	17..130	CDD:214735
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948
		S_TKc	525..895	CDD:214567
		HisS	974..1414	CDD:223202	110/492 (22%)
		class_II_aaRS-like_core	974..>1137	CDD:294192	45/191 (24%)
Hars1	NP_001020585.1	HisRS_RNA	5..49	CDD:238474	9/41 (22%)
		HisS	56..501	CDD:223202	112/510 (22%)
		HisRS-like_core	69..394	CDD:238396	85/381 (22%)
		HisRS_anticodon	408..499	CDD:238436	21/93 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810