DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gcn2 and Hars2

DIOPT Version :9

Sequence 1:	NP_001263142.1	Gene:	Gcn2 / 43709	FlyBaseID:	FBgn0019990	Length:	1591	Species:	Drosophila melanogaster
Sequence 2:	NP_001014034.2	Gene:	Hars2 / 307491	RGDID:	1308426	Length:	507	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	109/503 - (21%)
Similarity:	200/503 - (39%)	Gaps:	122/503 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   969 LNP----VIEFVKAKVVNLFRKHGAIEVDSPLLSPLSARNSTANANANAVH-LMTHSGCVVVLPC 1028
            |:|    |.|.:..|:::.|::|||..:|:|..............|...:: |....|.::.|..
  Rat    67 LSPQQMVVREKILDKIISCFKRHGAKGLDTPAFELKEMLTEKYEDNFGLMYDLEDQGGELLSLRY 131

  Fly  1029 DLRTQFARHVTMNSVNLIRRYCVDRVYREE--RVFNFHPKQSYDCSFDIIAPTTGSHLVDAELLS 1091
            ||...|||::.||.:..::||.|.:|:|.|  .:.....::...|.|| ||......:.|||.|.
  Rat   132 DLTVPFARYLAMNKLKRMKRYQVGKVWRRESPAIVQGRYREFCQCDFD-IAGEFDPMIPDAECLR 195

  Fly  1092 LAFEITSELPRLREKNLAIRMNHTNLLRAILIFCNVPKAQYGALF-------------------- 1136
            :..||   |..|:..:..|::|...::..:...|.||::::..:.
  Rat   196 IMCEI---LSGLQLGDFLIKVNDRRVVDGMFAVCGVPESKFRTICSSMDKLDKMSWEDVRLEMVA 257

  Fly  1137 -EGTMDFIESRISRF-QFHSSITGIME--------KSRTSAQTLMDM-LLANFL-LTGSRSTVDD 1189
             :|....:..||..: |.|..|:.:.|        :|:.:.|.|.|: ||..:| |.|    :.|
  Rat   258 GKGLAPEVADRIGDYVQCHGGISLVEELFKDPRLSQSQLALQGLGDLKLLFEYLRLFG----IAD 318

  Fly  1190 SALKSLMRGKGEAASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASNGGIVWQMTAD 1254
            .....|        ||||          ||.|..||                      :::....
  Rat   319 KISLDL--------SLAR----------GLDYYTGV----------------------IYEAVLL 343

  Fly  1255 LKPNRSGHPSV----LAIGERYDSMLHEFQKQAQKFNPAMPARGVLSGAGLTFSLDKLVAAVGVE 1315
            ..|.::|..::    :|.|.|||.::.:|..:..    ::|.      .||:..::::...|..:
  Rat   344 ESPAQAGKETLNVGSVAAGGRYDRLVAQFDPKGH----SVPC------VGLSIGVERIFYLVEQK 398

  Fly  1316 YAKDC---RAIDVGICVCGTRPP-LKDVTYIMRLLWSVGIRCGIV-----EAASELG-DEAQDLA 1370
            ....|   |..:..:.|...:.. |::...|:..||..||:..::     :..::|. .|.:|:.
  Rat   399 MKISCEKVRTTETQVFVATPQKNFLQERLKIIAQLWDAGIKAEMLYKNNPKLLTQLHYCEKEDIP 463

  Fly  1371 RLGALHVILVAE----NGSLRVRSFERERFQERHLTRTELVEFIQKML 1414
            .:     :::.|    .|.:::||....  :|..:.|..||..|||.|
  Rat   464 LM-----VIIGEQEQNEGVVKLRSVASR--EEVTVNRESLVAEIQKRL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD	17..130	CDD:214735
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948
		S_TKc	525..895	CDD:214567
		HisS	974..1414	CDD:223202	105/492 (21%)
		class_II_aaRS-like_core	974..>1137	CDD:294192	43/186 (23%)
Hars2	NP_001014034.2	HisS	58..505	CDD:223202	109/503 (22%)
		HisRS-like_core	71..396	CDD:238396	82/382 (21%)
		HisRS_anticodon	410..501	CDD:238436	18/97 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810