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Protein Alignment Gcn2 and HARS1

DIOPT Version :9

Sequence 1:	NP_001263142.1	Gene:	Gcn2 / 43709	FlyBaseID:	FBgn0019990	Length:	1591	Species:	Drosophila melanogaster
Sequence 2:	NP_002100.2	Gene:	HARS1 / 3035	HGNCID:	4816	Length:	509	Species:	Homo sapiens

Alignment Length:	588	Identity:	125/588 - (21%)
Similarity:	228/588 - (38%)	Gaps:	150/588 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   886 AQRPTAEELLISDLVPPAQLEANELQEMLRHALANPQSKAYKNLVARCLQQESDEVLEHTYHLGS 950
            |:|...|||:        :|:...::.:       .|.||...|:    ::|..::|:....||.
Human     2 AERAALEELV--------KLQGERVRGL-------KQQKASAELI----EEEVAKLLKLKAQLGP 47

  Fly   951 SRAMKSWNSAIIIDDIVSLNP------------VIEFVKAKVVNLFRKHGAIEVDSPLLSPLSAR 1003
            ..:.:.:         |...|            |.|.|...::..|::|||..:|:|:.......
Human    48 DESKQKF---------VLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETL 103

  Fly  1004 NSTANANANAVH-LMTHSGCVVVLPCDLRTQFARHVTMNSVNLIRRYCVDRVYREERVFNFHP-- 1065
            ......::..:: |....|.::.|..||...|||::.||.:..|:||.:.:|||.:     :|
Human   104 MGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRD-----NPAM 163

  Fly  1066 -----KQSYDCSFDIIAPTTGSHLVDAELLSLAFEITSELPRLREKNLAIRMNHTNLLRAILIFC 1125
                 ::.|.|.|| ||......:.|||.|.:..||.|.   |:..:..:::|...:|..:...|
Human   164 TRGRYREFYQCDFD-IAGNFDPMIPDAECLKIMCEILSS---LQIGDFLVKVNDRRILDGMFAIC 224

  Fly  1126 NVPKAQYGALF---------------------EGTMDFIESRISRF-QFHSSITGI--------M 1160
            .|..:::..:.                     :|....:..||..: |.|..::.:        :
Human   225 GVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKL 289

  Fly  1161 EKSRTSAQTLMDM-LLANFL-LTGSRSTVDDSALKSLMRGKGEAASLARGALRELETVVGLAYSL 1223
            .:::.:.:.|.|: ||..:| |.|    :||.....|        |||||    |:...|:.|.
Human   290 SQNKQALEGLGDLKLLFEYLTLFG----IDDKISFDL--------SLARG----LDYYTGVIYE- 337

  Fly  1224 GVKCPIHIWAGLPISFDRASNGGIVWQMTADLKPNRSGHPSVLAIGERYDSMLHEFQKQAQKFNP 1288
                                  .::.|..|.......|..|| |.|.|||.::..|..:.:|
Human   338 ----------------------AVLLQTPAQAGEEPLGVGSV-AAGGRYDGLVGMFDPKGRK--- 376

  Fly  1289 AMPARGVLSGAGLTFSL--DKLVAAVGVEYAKDCRAIDVGICVCGTRPP-LKDVTYIMRLLWSVG 1350
             :|..|:..|....||:  .:|.|     ..:..|..:..:.|...:.. |::...::..||..|
Human   377 -VPCVGLSIGVERIFSIVEQRLEA-----LEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAG 435

  Fly  1351 IRCGIV-EAASELGDEAQDLARLGALHVILVAE----NGSLRVRSF-ERERFQERHLTRTELVEF 1409
            |:..:: :...:|.::.|.....|...|.::.|    :|.:::||. .||....|   |.:|||.
Human   436 IKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVR---REDLVEE 497

  Fly  1410 IQK 1412
            |::
Human   498 IKR 500

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.