DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gcn2 and EIF2AK1

DIOPT Version :9

Sequence 1:NP_001263142.1 Gene:Gcn2 / 43709 FlyBaseID:FBgn0019990 Length:1591 Species:Drosophila melanogaster
Sequence 2:NP_055228.2 Gene:EIF2AK1 / 27102 HGNCID:24921 Length:630 Species:Homo sapiens


Alignment Length:467 Identity:146/467 - (31%)
Similarity:220/467 - (47%) Gaps:121/467 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   514 LALSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSR 578
            |....||...|||.|..||||.:|.|.||||.||.:.||||:|.:...::.:..|:.|||::|:.
Human   156 LEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAG 220

  Fly   579 LNHENVVRYFNSWIESV----------------------------------DDADAA-------- 601
            |.|.|:|.|..:|||.|                                  |::.::        
Human   221 LQHPNIVGYHTAWIEHVHVIQPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPT 285

  Fly   602 -EMDKLLGGEWSQSQQDLSVKPA------KSPQLGPTLEEDED--EEDSSSSMWNGYIP------ 651
             |.:|..|...:::|.:.|||..      :|.:|..|||..|:  ...|:||:....:|      
Human   286 PEKEKRFGESDTENQNNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSH 350

  Fly   652 ------NMEDSDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSPKPLMQVMYIQMEFCEKCTL-- 708
                  :.|:|..:.:.|:                   |:|.:...||  ::|||:.||....  
Human   351 LEESFTSTEESSEENVNFL-------------------GQTEAQYHLM--LHIQMQLCELSLWDW 394

  Fly   709 --------RTAIDDNL--FNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHD-QIKI 762
                    |..:|::.  :...:...::|:|:.||:.:||..||:||||||.||||...| |:||
Human   395 IVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKI 459

  Fly   763 GDFGLATTSFLALQAHDAAPAPVNQITSAEDG----TGTGKVGTTLYVAPE-LTGNASKSVYNQK 822
            ||||||.|..|          ..|...:..:|    |.|.:|||.||.:|| |.|    |.|:.|
Human   460 GDFGLACTDIL----------QKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEG----SEYDAK 510

  Fly   823 VDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQ 887
            .|||:||::|.|:.| ||.|.||||:.:..||  :..:|:::.|  :.....|.:|.|...:.:|
Human   511 SDMYSLGVVLLELFQ-PFGTEMERAEVLTGLR--TGQLPESLRK--RCPVQAKYIQHLTRRNSSQ 570

  Fly   888 RPTAEELLISDL 899
            ||:|.:||.|:|
Human   571 RPSAIQLLQSEL 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gcn2NP_001263142.1 RWD 17..130 CDD:214735
PK_eIF2AK_GCN2_rpt1 261..476 CDD:270914
STKc_EIF2AK4_GCN2_rpt2 518..898 CDD:270948 143/460 (31%)
S_TKc 525..895 CDD:214567 138/450 (31%)
HisS 974..1414 CDD:223202
class_II_aaRS-like_core 974..>1137 CDD:294192
EIF2AK1NP_055228.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
STKc_EIF2AK1_HRI 160..581 CDD:270951 143/460 (31%)
S_TKc 167..583 CDD:214567 142/456 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..301 4/41 (10%)
HRM 1 410..415 0/4 (0%)
HRM 2 552..557 0/4 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D433474at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2124
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.850

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