DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gcn2 and EIF2AK1

DIOPT Version :10

Sequence 1:NP_001263142.1 Gene:Gcn2 / 43709 FlyBaseID:FBgn0019990 Length:1591 Species:Drosophila melanogaster
Sequence 2:NP_055228.2 Gene:EIF2AK1 / 27102 HGNCID:24921 Length:630 Species:Homo sapiens


Alignment Length:467 Identity:146/467 - (31%)
Similarity:220/467 - (47%) Gaps:121/467 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   514 LALSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSR 578
            |....||...|||.|..||||.:|.|.||||.||.:.||||:|.:...::.:..|:.|||::|:.
Human   156 LEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAG 220

  Fly   579 LNHENVVRYFNSWIESV----------------------------------DDADAA-------- 601
            |.|.|:|.|..:|||.|                                  |::.::        
Human   221 LQHPNIVGYHTAWIEHVHVIQPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPT 285

  Fly   602 -EMDKLLGGEWSQSQQDLSVKPA------KSPQLGPTLEEDED--EEDSSSSMWNGYIP------ 651
             |.:|..|...:::|.:.|||..      :|.:|..|||..|:  ...|:||:....:|      
Human   286 PEKEKRFGESDTENQNNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSH 350

  Fly   652 ------NMEDSDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSPKPLMQVMYIQMEFCEKCTL-- 708
                  :.|:|..:.:.|:                   |:|.:...||  ::|||:.||....  
Human   351 LEESFTSTEESSEENVNFL-------------------GQTEAQYHLM--LHIQMQLCELSLWDW 394

  Fly   709 --------RTAIDDNL--FNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHD-QIKI 762
                    |..:|::.  :...:...::|:|:.||:.:||..||:||||||.||||...| |:||
Human   395 IVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKI 459

  Fly   763 GDFGLATTSFLALQAHDAAPAPVNQITSAEDG----TGTGKVGTTLYVAPE-LTGNASKSVYNQK 822
            ||||||.|..|          ..|...:..:|    |.|.:|||.||.:|| |.|    |.|:.|
Human   460 GDFGLACTDIL----------QKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEG----SEYDAK 510

  Fly   823 VDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQ 887
            .|||:||::|.|:.| ||.|.||||:.:..||  :..:|:::.|  :.....|.:|.|...:.:|
Human   511 SDMYSLGVVLLELFQ-PFGTEMERAEVLTGLR--TGQLPESLRK--RCPVQAKYIQHLTRRNSSQ 570

  Fly   888 RPTAEELLISDL 899
            ||:|.:||.|:|
Human   571 RPSAIQLLQSEL 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gcn2NP_001263142.1 RWD_GCN2 11..131 CDD:467659
PK_eIF2AK_GCN2_rpt1 261..476 CDD:270914
STKc_EIF2AK4_GCN2_rpt2 518..898 CDD:270948 143/460 (31%)
class_II_aaRS-like_core 974..>1137 CDD:444800
PRK12420 1029..1392 CDD:237097
EIF2AK1NP_055228.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
SIFI-degron. /evidence=ECO:0000269|PubMed:38297121 85..104
STKc_EIF2AK1_HRI 160..581 CDD:270951 143/460 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..301 4/41 (10%)
HRM 1 410..415 0/4 (0%)
HRM 2 552..557 0/4 (0%)
Blue background indicates that the domain is not in the aligned region.

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