DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gcn2 and hri1

DIOPT Version :9

Sequence 1:	NP_001263142.1	Gene:	Gcn2 / 43709	FlyBaseID:	FBgn0019990	Length:	1591	Species:	Drosophila melanogaster
Sequence 2:	NP_594738.1	Gene:	hri1 / 2541728	PomBaseID:	SPAC20G4.03c	Length:	704	Species:	Schizosaccharomyces pombe

Alignment Length:	671	Identity:	187/671 - (27%)
Similarity:	266/671 - (39%)	Gaps:	208/671 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 LHNKGVSHSHLLDTTVFMDNTGNVRVSDFS-------LVPNLLELLSGAGQSSSCGDL-PALGAL 441
            |||   ..|....:|:.|.:|.:.:.|.:|       ...:.|.:||..|......:: |::..|
pombe   104 LHN---LLSKAFRSTLPMSSTKDSKKSRYSSPDGVLAKTASFLSVLSDGGYEDDVMNVKPSVNVL 165

  Fly   442 -----------VESLMPTNSYEMRDFVDKC-NSDRT--LSASELLEHPFLRFYVDNGQQQVMPLP 492
                       :||..|..:.|...|.|.| :.|.|  ||.|.....|
pombe   166 SNRLNHLPVEALESCFPQTTLESSTFADFCEHKDGTGNLSFSNFDSFP----------------- 213

  Fly   493 QQQHPNTVQRTGSAMPYQIPTLALSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIP 557
                  ||||                ||..::||.|..||||.:|.|.|.||..|..|||:|:||
pombe   214 ------TVQR----------------SRYASDFEELELLGKGGYGSVYKARNKFDGVEYALKKIP 256

  Fly   558 LPARSRQLYKKMTREVELLSRLNHENVVRYFNSWIE---------------SVDD--ADAAEMDK 605
            |..||......:.||...|:||||.||:|:|:||:|               |.|:  :.:|::|.
pombe   257 LRLRSFSTSSNIFRESRTLARLNHPNVIRFFSSWVELLPSSEKQIEEEPLASADETLSQSADIDN 321

  Fly   606 --------LLGGEWSQSQQDLSVKPAKSPQLGP------------TLEEDEDEEDSSSSMWNGYI 650
                    ||...:..|.|.|..:.:.:..|.|            .|.:.|.::|.:.|
pombe   322 FMFDMDTGLLQHTYPSSVQILFQEDSVADDLTPCYSTKNSTCNLTDLFKKEADQDYAES------ 380

  Fly   651 PNMEDSDSDGIEFVDSNGKVA------------VYDDEEQEDSTRGKTNSP----KPLMQVMYIQ 699
               .|..|...: ||:.||:|            .:..|.:||..   :|.|    :||  .:|||
pombe   381 ---HDCSSTTSQ-VDTLGKLAPTKSASEMLLMDSFLSEREEDEC---SNIPSFDQQPL--CLYIQ 436

  Fly   700 MEFCEKCTLRTAI---DDNLFNDTDRLWR-----LFREIAEGLAHIHQ-QGIIHRDLKPVNIFLD 755
            |..||: ||...|   :.::.....:..|     ||..|.||:.::|. ..::||||||.||||.
pombe   437 MALCEE-TLEKHINRRNKHIHGVMSKGLRNCYILLFARILEGVLYLHDAMHLVHRDLKPRNIFLS 500

  Fly   756 S----------------HDQI------------------KIGDFGLATTSFLALQAHDAAPAPVN 786
            |                .|.:                  |||||||.                ::
pombe   501 SGVHSEPCSVCLPNFSDEDNVEVSNAYEPVNQRTLCVVPKIGDFGLV----------------LS 549

  Fly   787 QITSAEDGTGTGK----VGTTLYVAPELTGNASKSVY--NQKVDMYTLGIILFEMCQPPFDTSME 845
            |..:.|:||.:..    |||:.|.||||.....:||.  |...|:|.|||:.||:.. ||:|.||
pombe   550 QSDNLEEGTNSSAESSFVGTSTYAAPELFSKHMRSVMNNNSSTDIYALGILFFELLY-PFNTRME 613

  Fly   846 RAQTIMALRNVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANEL 910
            ||..|..|:. .|...|.:...|:....::.:....|    :||||.:||.|:|.  ..|..|||
pombe   614 RASAIANLKK-GIFPHDFLDSMPEEASLIRSMLSSSN----KRPTAAQLLTSNLF--HDLVVNEL 671

  Fly   911 QEMLRHALANPQSKAYKNLVA 931
            .  :..||.....|...||.|
pombe   672 H--VYQALLEDAEKRNNNLKA 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD	17..130	CDD:214735
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914	27/112 (24%)
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	143/481 (30%)
		S_TKc	525..895	CDD:214567	139/471 (30%)
		HisS	974..1414	CDD:223202
		class_II_aaRS-like_core	974..>1137	CDD:294192
hri1	NP_594738.1	STKc_EIF2AK	217..661	CDD:270898	144/497 (29%)
hri1	NP_594738.1	Pkinase	224..658	CDD:278497	139/471 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	73	1.000	Domainoid score	I2572
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2124
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940