Protein Alignment Gcn2 and HARS2

DIOPT Version :10

• Sequence 1: NP_001263142.1
• Gene: Gcn2 / 43709
• FlyBaseID: FBgn0019990
• Length: 1591
• Species: Drosophila melanogaster
• Sequence 2: NP_001350464.1
• Gene: HARS2 / 23438
• HGNCID: 4817
• Length: 512
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 121/549 - (22%)
• Similarity: 220/549 - (40%)
• Gaps: 83/549 - (15%)

  Fly   902 PAQLEANELQEMLRHALANPQSKAYKNLVARCLQQ--ESDEVLEHTYHLGSSRAMKSWNSAIII- 963
            |.:..|:.|.::||...|:...      ..||..|  ||.:|.|..  |.|...........||
Human     8 PRRAWASLLSQLLRPPCASCTG------AVRCQSQGEESLQVAEAV--LTSQLKAHQEKPNFIIK 64

  Fly   964 --DDIVSLNPVIEFVKAKVVNL----FRKHGAIEVDSPLLSPLSARNSTANANANAVH-LMTHSG 1021
              .....|:|....|:.|:::|    |::|||..:|:|..............::..:: |....|
Human    65 TPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDSGLMYDLKDQGG 129

  Fly  1022 CVVVLPCDLRTQFARHVTMNSVNLIRRYCVDRVYREE--RVFNFHPKQSYDCSFDIIAPTTGSHL 1084
            .::.|..||...|||::.||.|..::||.|.:|:|.|  .:.....::...|.|| ||......:
Human   130 ELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRYREFCQCDFD-IAGQFDPMI 193

  Fly  1085 VDAELLSLAFEITSELPRLREKNLAIRMNHTNLLRAILIFCNVPKAQYGALFEGTMDFIESRISR 1149
            .|||.|.:..||   |..|:..:..|::|...::..:...|.||::::.|:. .::|.::....:
Human   194 PDAECLKIMCEI---LSGLQLGDFLIKVNDRRIVDGMFAVCGVPESKFRAIC-SSIDKLDKMAWK 254

  Fly  1150 FQFHSSITGIMEKSRTSAQTLMDMLLANFLLTGSRSTVDD-------SALKSLMRGKGEAASLAR 1207
            ...|..:.     .:..|..:.|.:.......|..|.|:.       |..|..:.|.|:..
Human   255 DVRHEMVV-----KKGLAPEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALEGLGDLK---- 310

  Fly  1208 GALRELETVVGLAYSLGVKCPIHIWAGLPISFDRA-SNG-----GIVWQMTADLKPNRSGHPSV- 1265
             .|.|..|:.|:|..              ||||.: :.|     |::::......|.::|...:
Human   311 -LLFEYLTLFGIADK--------------ISFDLSLARGLDYYTGVIYEAVLLQTPTQAGEEPLN 360

  Fly  1266 ---LAIGERYDSMLHEFQKQAQKFNPAMPARGVLSGAGLTFSL-DKLVAAVGVEYAKDCRAIDVG 1326
               :|.|.|||.::..|..:..|    :|..|:..|....|.: ::.:...|    :..|..:..
Human   361 VGSVAAGGRYDGLVGMFDPKGHK----VPCVGLSIGVERIFYIVEQRMKTKG----EKVRTTETQ 417

  Fly  1327 ICVCGTRPP-LKDVTYIMRLLWSVGIRCGIV-EAASELGDEAQDLARLGALHVILVAE----NGS 1385
            :.|...:.. |::...::..||..||:..:: :...:|..:.......|...|:::.|    .|.
Human   418 VFVATPQKNFLQERLKLIAELWDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGV 482

  Fly  1386 LRVRSFERERFQERHLTRTELVEFIQKML 1414
            :::||....  :|..:.|...|..|||.|
Human   483 IKIRSVASR--EEVAIKRENFVAEIQKRL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD_GCN2	11..131	CDD:467659
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948
		class_II_aaRS-like_core	974..>1137	CDD:444800	45/169 (27%)
		PRK12420	1029..1392	CDD:237097	83/388 (21%)
HARS2	NP_001350464.1	PLN02972	<12..510	CDD:215525	120/545 (22%)