Protein Alignment Gcn2 and Eif2ak2

DIOPT Version :9

• Sequence 1: NP_001263142.1
• Gene: Gcn2 / 43709
• FlyBaseID: FBgn0019990
• Length: 1591
• Species: Drosophila melanogaster
• Sequence 2: XP_006523926.1
• Gene: Eif2ak2 / 19106
• MGIID: 1353449
• Length: 529
• Species: Mus musculus
• Alignment Length: 603
• Identity: 150/603 - (24%)
• Similarity: 220/603 - (36%)
• Gaps: 223/603 - (36%)

  Fly   372 RMVARGVLDALVFLHNKGVSHSHLLDTTV-----FMDNTGNV----RVSDFSL-VPNLLELLSGA 426
            |...:.::|...|...||.|.....:...     .:||...|    ..|:..| |.|.:.|::..
Mouse    53 RFTFQVLIDEKEFPEAKGRSKQEARNAAAKLAVDILDNENKVDCHTSASEQGLFVGNYIGLVNSF 117

  Fly   427 GQSSSCGDLPALGALVESLMPTNSYEMRDFVDKCNSDRT---------------LSASE----LL 472
            .|...      |....|...|.:....| |:.||...:|               |:|.|    ||
Mouse   118 AQKKK------LSVNYEQCEPNSELPQR-FICKCKIGQTMYGTGSGVTKQEAKQLAAKEAYQKLL 175

  Fly   473 EHP--------------FLRF-----YVDNGQQQVMP------------LPQQQH-------PNT 499
            :.|              |..|     ...||..|..|            |.:.:.       |:.
Mouse   176 KSPPKTAGTSSSVVTSTFSGFSSSSSMTSNGVSQSAPGSFSSENVFTNGLGENKRKSGVKVSPDD 240

  Fly   500 VQRTGSAMPYQIPTLALSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQ 564
            |||....:          .:|..::||.:..:|.|.||.|.|.::.:|.:.|||||:      :.
Mouse   241 VQRNKYTL----------DARFNSDFEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRV------KY 289

  Fly   565 LYKKMTREVELLSRLNHENVVRYFNSWIESVDDADAAEMDKLLGGEWSQSQQDLSVKPAKSPQLG 629
            ..:|...||:.|:.|||.|:|:|.:.| |.||
Mouse   290 NTEKAEHEVQALAELNHVNIVQYHSCW-EGVD--------------------------------- 320

  Fly   630 PTLEEDEDEEDSSSSMWNGYIPNMEDSDSDGIEFVDSNGKVAVYDDE-EQEDSTRGKTNSPKPLM 693
                                                       ||.| ...|::|.||
Mouse   321 -------------------------------------------YDPEHSMSDTSRYKT------- 335

  Fly   694 QVMYIQMEFCEKCTL--------RTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPV 750
            :.::||||||:|.||        ::.:|..|..|      |:.:|..|:.:||.:|:|||||||.
Mouse   336 RCLFIQMEFCDKGTLEQWMRNRNQSKVDKALILD------LYEQIVTGVEYIHSKGLIHRDLKPG 394

  Fly   751 NIFLDSHDQIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDG-TGTGKVGTTLYVAPELTGNA 814
            ||||.....||||||||||    ||:               .|| :.|.:.||..|::||   ..
Mouse   395 NIFLVDERHIKIGDFGLAT----ALE---------------NDGKSRTRRTGTLQYMSPE---QL 437

  Fly   815 SKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALR--NVSINIPDAMLKDPKYEKTVKML 877
            ....|.::||::.||:||.|:....| |..|:.:...:||  :.|.:|.|        .|...:|
Mouse   438 FLKHYGKEVDIFALGLILAELLHTCF-TESEKIKFFESLRKGDFSNDIFD--------NKEKSLL 493

  Fly   878 QWLLNHDPAQRPTAEELL 895
            :.||:..|..||...|:|
Mouse   494 KKLLSEKPKDRPETSEIL 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD	17..130	CDD:214735
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914	29/146 (20%)
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	110/390 (28%)
		S_TKc	525..895	CDD:214567	108/381 (28%)
		HisS	974..1414	CDD:223202
		class_II_aaRS-like_core	974..>1137	CDD:294192
Eif2ak2	XP_006523926.1	DSRM_EIF2AK2_rpt1	21..88	CDD:380732	6/34 (18%)
		DSRM_EIF2AK2_rpt2	108..175	CDD:380733	14/73 (19%)
		PKc_like	249..514	CDD:389743	110/390 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433474at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920