DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gcn2 and pek-1

DIOPT Version :9

Sequence 1:NP_001263142.1 Gene:Gcn2 / 43709 FlyBaseID:FBgn0019990 Length:1591 Species:Drosophila melanogaster
Sequence 2:NP_509912.1 Gene:pek-1 / 181334 WormBaseID:WBGene00003970 Length:1077 Species:Caenorhabditis elegans


Alignment Length:1100 Identity:244/1100 - (22%)
Similarity:381/1100 - (34%) Gaps:392/1100 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KAKESFRERQAQELEVIKSIFGCDVEDLRPQANPSLWKPTDIRIQLTPLR--DSSNGLETY---- 63
            |..:.|...|..|.    |:..|...|.....||.:.    ||.....:|  |:..|:|.:    
 Worm   153 KGFDLFTGEQKYEC----SMESCGPGDTETPKNPIIL----IRRTTNSIRAMDTLRGIERWNLST 209

  Fly    64 ----VCTKLHVTCPS-----KYPKLPP--------KISLEESKGMSD----QLLEALRNQLQAQS 107
                |.....:|.|:     |....||        |.:.||.|...|    .:.:...||:    
 Worm   210 AEIGVTLAGGITSPTLVSDVKILLQPPDGVIVAVDKYNREEWKTNVDGHIVSVWQVYGNQI---- 270

  Fly   108 QELRGEVMIYELAQTVQAFLLEHNKPPKGSFYDQMLQDKQKRDQELQDIQRQRESLQRQT----- 167
                ||:.|::               |...|..|           .:.:||::.:||.|:     
 Worm   271 ----GEISIFD---------------PSNIFTTQ-----------YEVMQREQHNLQTQSSLLYM 305

  Fly   168 -------LIDEVERRKEMFKTEAKRRGEPRRSMSESNPRHPSSSESSENSSPYYRGHIYPSKCLD 225
                   .|.:..:.|...|.......|.......:|||..:::|.:       |...|..|   
 Worm   306 GTSNGFPFIIQSPKAKNNLKQRMNALPELSTMTELTNPRFCTANEET-------RSLAYNVK--- 360

  Fly   226 HRNTETLYFHKMGRQIQRGCCVGEGHSQRGCIAYTGIDMHCGQLLYITEWNIKYSQLEQPCIGGG 290
             ..|..|..|...|           |||...|                         |...:.|.
 Worm   361 -DETLRLVLHNAFR-----------HSQSKAI-------------------------EDKSLSGS 388

  Fly   291 KCHWSSESKCMGSHRVDEVMASIEKQVSSLSQLQHKNLVSYECVLCIKRKEGLLVYLVQD----- 350
                       .:.|..:::|| :.:||: .::..:||.|...     .|.|...|||.:     
 Worm   389 -----------SARRKLQIIAS-DTEVSA-QRIGTENLRSTSV-----SKSGDYGYLVLESEPQR 435

  Fly   351 --FLLGTSVFSISSSLGWCMDGARMVA-----RGVLDALVFLHNKGVSHS-----HLLDTTVFMD 403
              |.:.:.:..:.:...:..:...:|:     .||..|:|:  ||....|     ||..|.....
 Worm   436 VKFKVNSPITLMQTIFSYIFNPTAVVSFLAGLIGVTVAVVY--NKIAKSSPRMIEHLSSTESAET 498

  Fly   404 NTGNVRVSDFSLVPNLLELLSGAGQSSSCGDLPALGAL-VESLMPTNSYEMRDFVDKCNSDRTLS 467
            .:.:.|....|..|...|:.....:.|.....| :||: .:.|||         ::|.|.:    
 Worm   499 ESASHRTRTTSFAPTDDEIERFVEEGSDLSTTP-IGAIHRKPLMP---------IEKSNIE---- 549

  Fly   468 ASELLEHPFLRFYVDNGQQQVMPL----------PQQQHPN----------TVQRTGSAMPYQIP 512
                          .:.|.|:.|:          .:....|          |:.|:         
 Worm   550 --------------THTQPQIKPVQRLVKTDIDTDEDSFSNDEKKRLLRNRTISRS--------- 591

  Fly   513 TLALSQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPL----PARSRQLYKKMTREV 573
            :|....||...||||...:|.|.||.|.:.::|.|..|||:|||.:    .||:|.|     ||.
 Worm   592 SLEGFTSRFANEFEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVADNDKARNRVL-----REA 651

  Fly   574 ELLSRLNHENVVRYFNSW-------------------------------------------IESV 595
            ..|:..:|..::|||.:|                                           :.|.
 Worm   652 RALAMFDHPGIIRYFYAWEERPPKGFQEKEDENLLGKIKAEKLAKLHEIKKAKKHTSEGKRVRSA 716

  Fly   596 DDADAAE---MDKLLG------GEWSQSQ-----------------------------QDLSVKP 622
            |.|..||   |..::|      ..||.|.                             ::.||..
 Worm   717 DTASFAESFAMPPVVGNTTDAENSWSTSAKPQEVGAKRTTSESKLGLHGGSDRTTAELKEESVAF 781

  Fly   623 AKSPQLGPTLEEDEDEEDSSSSMWNGYI---PNMEDSDSDGIEFVDSNG------------KVAV 672
            ::|.:...|.|:....::|.||.....|   |...:|.|.||||||.:.            ::||
 Worm   782 SESDEESDTTEDSSSSDESPSSSSGSSIDDEPKKYNSSSGGIEFVDGSDDVDNEAVKETKKEIAV 846

  Fly   673 YDD------------EEQEDSTRGKTNSPKPLMQVMYIQMEFCEKCTL-------RTAIDDNLFN 718
            .::            |.||...|.:.::..  ...:||.|:.|.:.||       :|.....|| 
 Worm   847 IEELSIHNRAMIVETENQELEVRERNDTGD--CAYLYIVMQLCAEKTLEDWIRRSKTMESRPLF- 908

  Fly   719 DTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIF--LDS---HDQIKIGDFGLATTSFLALQAH 778
             |.:.|  .:::|.||.::|.:|.|||||||.|:|  |||   |..:||||.||||.:       
 Worm   909 -TMKNW--IKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLATKT------- 963

  Fly   779 DAAPAPVNQITSAEDGTGTGK----VGTTLYVAPELTGNASKSVYNQKVDMYTLGIILFEMCQPP 839
            |.||    :||..:|...:.|    |||..|::||   ......|.:|||::.||::..|:. ..
 Worm   964 DGAP----KITVRQDSDSSAKHTKNVGTRSYMSPE---QLKHQQYTEKVDIFALGLVATELI-IS 1020

  Fly   840 FDTSMERAQTIMALRNVSI-----NIPDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEEL 894
            |.|:.||..|....:...|     |:|::  :|        .|..|.:.:|::||||.|:
 Worm  1021 FSTASERIHTFADFQKGDIPAILDNVPES--RD--------FLLQLTSLEPSERPTAHEV 1070

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gcn2NP_001263142.1 RWD 17..130 CDD:214735 28/139 (20%)
PK_eIF2AK_GCN2_rpt1 261..476 CDD:270914 40/232 (17%)
STKc_EIF2AK4_GCN2_rpt2 518..898 CDD:270948 139/509 (27%)
S_TKc 525..895 CDD:214567 136/502 (27%)
HisS 974..1414 CDD:223202
class_II_aaRS-like_core 974..>1137 CDD:294192
pek-1NP_509912.1 Luminal_IRE1_like 54..333 CDD:276097 42/221 (19%)
STKc_EIF2AK3_PERK 597..1074 CDD:270950 139/509 (27%)
S_TKc 836..1076 CDD:214567 80/265 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D433474at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

Return to query results.
Submit another query.