DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gcn2 and gcn-2

DIOPT Version :9

Sequence 1:NP_001263142.1 Gene:Gcn2 / 43709 FlyBaseID:FBgn0019990 Length:1591 Species:Drosophila melanogaster
Sequence 2:NP_001367229.1 Gene:gcn-2 / 174953 WormBaseID:WBGene00013591 Length:1699 Species:Caenorhabditis elegans


Alignment Length:1860 Identity:439/1860 - (23%)
Similarity:751/1860 - (40%) Gaps:441/1860 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DEKAKESFRERQAQELEVIKSIFGCDVEDLRPQANPSLWKPTDIRIQLTPLRDSS--NG---LET 62
            ||:.||: :..|.:|...:.:::...:..::  |:..:|.||:..|.|..| ||.  ||   .::
 Worm    10 DERVKEN-QHLQEEEKLALDAVYLNQITYIK--AHWHVWVPTNCHILLKAL-DSCFLNGDPLGKS 70

  Fly    63 YVCTKLHVTCPSKYPKLPPKISLEESKGMSDQLLEALRNQLQAQSQELRGEVMIYELAQTVQAFL 127
            .:...|||.|...||:..|.:.|.:.:|:|.:.::.|...|:..:....|.|:|.|||..|:.||
 Worm    71 KLSVILHVKCSEDYPQRKPAVDLLDPQGLSKEDVQNLLTILRQMADTWEGCVVIAELAHRVREFL 135

  Fly   128 LEHNKPPKGSFYDQMLQDKQKRDQELQDIQRQRESLQRQTLIDEVERRK--EMFKTEAKRRGE-- 188
            .:|...|.|||:|.||.:|.:.:.|.|..:...|..:.:.|.:|:.:|.  ||.||....|.|  
 Worm   136 TDHTPRPAGSFHDDMLANKVRTEAEKQRKRLDTEQKELELLEEEMRQRNAIEMEKTLNGTRQENE 200

  Fly   189 -----PRRSMSESNPRHPSSSESSENSSPYYRGHIYPSKCLDHRNTETLYFHKMGRQIQRGCCVG 248
                 .||.:..||                     .|       ||:                  
 Worm   201 TRIIGGRRIVVLSN---------------------MP-------NTQ------------------ 219

  Fly   249 EGHSQRGCIAYTGIDMHCGQLLYITEWNIKYSQLEQPCIGGGKCHWSSESKCMGSHRVDEVMASI 313
                                 |.|:||..::|....|..|..|      .......::|.|...|
 Worm   220 ---------------------LLISEWTFRFSSNRNPAEGKRK------DFAPFLQKLDAVYNEI 257

  Fly   314 EK--QVSSLSQLQHKNLVSYECV-----------LCIKRKEGLLVYLVQDFLLGTSVFSISSSLG 365
            :|  ::..|.|    |||.|..|           :.|:......::..::.:..|....:..|  
 Worm   258 QKLCEIKGLDQ----NLVEYAFVHLQKISVSPDQILIQLNVAQKIFSSEENMQDTYELIVQKS-- 316

  Fly   366 WCMDGARMVARGVLDALVFLHNKGVSHSHLLDTTVFMDN-TGN--VRVSDFSLVPNLLELLSGAG 427
               :..|::|...:..|.:||...::|.||...:|:..| ||:  .|.|||..:..||:|:...|
 Worm   317 ---NLLRLLAAQAICGLRYLHEASMTHKHLTLGSVWTRNSTGDCVFRFSDFGSMGPLLDLVKMFG 378

  Fly   428 QSSSCG------------------DLPALGALVESLM-------------------PTNSYEMRD 455
            ...| |                  ||..||.|::.|:                   .|.:..:.:
 Worm   379 DICS-GKYVARDEDKEKEYDRRRKDLFQLGTLLDGLILATRGSTYSRVPTPVEGNQNTGTNLLGN 442

  Fly   456 FVDKCNSDRTLSASELLEHPFLRFYVDNGQQQVMPLPQQQHPNTVQRTGSAMPYQIPTLALSQSR 520
            |:.||...:.:  .:|:|.|||:...           |.:..|.....|.||.        ...|
 Worm   443 FIAKCQEAKNI--DQLVEDPFLKEEC-----------QSESENIFTPFGGAMS--------PDGR 486

  Fly   521 LRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENVV 585
            :..:..::..||:|.||||:.|||.:|:.:||||||||.|:|.:|.:|:.:|.:..::|||.|:|
 Worm   487 MLADNVIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLNAKSDKLNRKIAKEAKFFAKLNHPNMV 551

  Fly   586 RYFNSW-------IESVDDADAA-------------EMDKL--------------LGG------- 609
            ||:.:|       :|...|.|::             :..||              |||       
 Worm   552 RYYYAWAEDLIPIVEETSDDDSSLGAVPIPGKEKIGKKGKLKTGKSLEDKENKANLGGGDSLMPM 616

  Fly   610 ----------------EWS--------------QSQQDLSVKPAKSPQLGPTLEEDEDEEDSSSS 644
                            |||              ..|...|........|.....:|||::|||..
 Worm   617 NLRGLVKDHSIGVDAKEWSTPFGKPEGPKCASRMRQSKRSTPSGGLKHLSECSSDDEDDDDSSEI 681

  Fly   645 MWNGYIPNMEDSDSDGIEFVD--------------SNGKVAVYD----DE------EQEDSTRGK 685
            .|:.....:||.:||..:..|              |.|..:|::    ||      |.||....:
 Worm   682 DWDAESEEVEDEESDDSDEEDEDDGERLVQLNTETSTGADSVFERSTADEDVVFTAESEDLNAKR 746

  Fly   686 TNS---------------------PKPLMQVMYIQMEFCEKCTLRTAIDDN-LFNDTDRLWRLFR 728
            ..|                     |....:::.||||:|::.|||..||:| .||....:||:|.
 Worm   747 RESIELMEINTTTTSKSKLAIDVVPVRKPRILCIQMEYCDRATLRQYIDENHCFNAPTEVWRIFS 811

  Fly   729 EIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAH------------DAA 781
            |:..||.::|...:||||:||:||||.|.:.:|||||||||...::.:..            :|.
 Worm   812 EVLCGLKYMHDMAMIHRDIKPLNIFLTSQNGVKIGDFGLATLEAMSSKGKIVGGAAEKSTSIEAM 876

  Fly   782 PAPVNQITSAEDGTGTGKVGTTLYVAPELTGN--ASKSVYNQKVDMYTLGIILFEMCQPPFDTSM 844
            .:|....:...|...|..:||.||:||||..:  ..|:.|..|:|:|:.|::||||...|...||
 Worm   877 LSPNGVKSKGSDVHQTRDIGTQLYMAPELFVDELVHKAPYTSKIDIYSAGVVLFEMFYRPLPPSM 941

  Fly   845 ERAQTIMALRNVSINIPD---AMLKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLE 906
            :|..|:..||: .|.||.   |.|..|......:.::.:|..:|.:||||::||..:.:|....|
 Worm   942 DRVSTLNNLRD-DIKIPSDFGAGLAAPMAGLARRTVEKMLQRNPDERPTADDLLNDEDLPMHTKE 1005

  Fly   907 ANELQEMLRHALANPQSKAYKNLVARCLQQESDEVLEHTYHLGSSRAMKSWNSAIIIDDIVSLNP 971
            ....:.:....:.....:....|:.:..::|....|.:.|.:........:|:..::        
 Worm  1006 DATFRNLCEKVIKKRDGRMNAWLLDKQFKEEVPTSLNYCYDVDICLERAKYNNREVL-------- 1062

  Fly   972 VIEFVKAKVVNLFRKHGAIEVDSPLLSPLSARNSTANANANAVHLMTHSGCVVVLPCDLRTQFAR 1036
             :|.::|:...:.:.|...::.:..|.|:|...:.|:.....|.::..||..|.||.|||..|.|
 Worm  1063 -VETLRAEFCKILKIHSFEKLHTHTLMPVSTALAAASVRTKPVEVLDRSGVPVALPMDLRQNFVR 1126

  Fly  1037 HVTMNSVNLIRRYCVDRVYREERVFNFHPKQSYDCSFDIIAPTTGSHLVDAELLSLAFE-ITSEL 1100
            ....|||..::|:...|||.:... |.||.:.::|..|.|.|...|..::||||.:|.| :...|
 Worm  1127 FCVRNSVQRMKRFNFGRVYSQTSA-NGHPHERWECCVDCIGPQCSSPSLEAELLLVACEMMIGSL 1190

  Fly  1101 PRLREKNLAIRMNHTNLLRAILIFCNVPKAQYGALFEGTMDFIESRISRFQFHSSITGIMEKSRT 1165
            |.::   ..:::.|..|:.|.:....:.......|.:.             .|  :..:.::.. 
 Worm  1191 PGMK---FTLKIGHAQLIEAQIRHLKLSDDVRAELLDA-------------LH--LISVSDRPH- 1236

  Fly  1166 SAQTLMDML-------LANFLLTGSRSTVDDS--ALKSLM-----RGKGEAAS-LARGALRELET 1215
            |.:..||||       .|| ::|.....|:|:  |.|..:     :.|.:||. |...|:|:||.
 Worm  1237 SHKEKMDMLTPKIGAKAAN-IITKLLIPVEDNFGAFKEKVACFRKKLKVDAARVLVDKAIRDLEE 1300

  Fly  1216 VVGLAYSLGVKCPIHIWAGLPISFD-------RASNGGIVWQMTADLKP-----NRSGHPSVLAI 1268
            :|| .:..   |.......:.|.:|       |....|:::|:..: ||     |:.|....:..
 Worm  1301 IVG-TFKF---CRTEAIEQISIVYDSQTCYRPRTFGDGLLFQIQVE-KPSTIANNKRGRRQNVLA 1360

  Fly  1269 GERYDSMLHEFQKQAQKFNPAMPARGVLSGAGLTFSL-----DKLVAAVGVEYA--KDCRAIDVG 1326
            |.||||.|.. ::..:.|...:|.  .:||.|:...:     |.:..:..:...  ..|:     
 Worm  1361 GGRYDSALLR-ERHPRDFVYEIPL--CISGFGVAMDVVSQIRDSINKSANIPKTPQNHCK----- 1417

  Fly  1327 ICVCGTRPP-----LKDVTYIMRLLWSVGIRCGIVE-AASELGDEAQDLARLGALHVILVAENGS 1385
            :.:|....|     :.....:.:.|||:||...:.. ...:|....:...|....|::.|....:
 Worm  1418 VLICSMVQPDGSNLITQKFELAKKLWSMGIEADVFHIPVDDLESLTEHRNRASITHILAVYNTLN 1482

  Fly  1386 LRVRSFERERFQERHLTRTELVEF---IQKMLRS-DGLNGTTVDNFSQLSALGSG--DNRSSGGK 1444
            ..:...|         |.:|.::.   |..:.|. ..|:|.::    .::..|.|  .:.|:.|:
 Worm  1483 EVICKTE---------TSSETMDVDSAISSVWRGVQALDGQSI----HMTPCGGGPISSISTPGE 1534

  Fly  1445 ERERGE--------------NGLSTSASNATIKNNYSQLPNLQVTFLTH-DK--PTANYKRRLEN 1492
            .....:              :.:||:.:..:|:...:.:.||.|..:|. |:  .....|:|:|:
 Worm  1535 AHHHDDHHPGTPVIASKCFRSSVSTTVATTSIRPISATVANLNVILVTSADRFHKVMKEKKRVES 1599

  Fly  1493 QVAQQMSSTLSQFLKKETFVVLVVELPPAVVNAIVGAINPREIRKRETEPEINYVIER-FSKY-K 1555
            ||...::..::.|..|....|||.::|..|:..||.     |:.|..:|.||:.:.:: ..|: |
 Worm  1600 QVRNHLTEFVAHFTSKTRIEVLVCDIPADVIKKIVS-----ELTKTSSEAEIDKLFDQLIQKHGK 1659

  Fly  1556 RYISEINEE---VVDYLSDAKTPIVAL-YSISDSYYRVII 1591
            ..:|.:..:   .::.:|.....:..| |..||::||.::
 Worm  1660 VDLSPLRRQFHITLNGISTGSAQVAILFYRQSDNFYRYLV 1699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gcn2NP_001263142.1 RWD 17..130 CDD:214735 33/117 (28%)
PK_eIF2AK_GCN2_rpt1 261..476 CDD:270914 56/267 (21%)
STKc_EIF2AK4_GCN2_rpt2 518..898 CDD:270948 152/513 (30%)
S_TKc 525..895 CDD:214567 149/503 (30%)
HisS 974..1414 CDD:223202 106/483 (22%)
class_II_aaRS-like_core 974..>1137 CDD:294192 45/163 (28%)
gcn-2NP_001367229.1 RWD 23..138 CDD:214735 33/117 (28%)
PKc_like 217..>373 CDD:419665 42/209 (20%)
PKc_like 486..>560 CDD:419665 33/73 (45%)
PKc_like <776..997 CDD:419665 83/221 (38%)
class_II_aaRS-like_core 1106..>1227 CDD:412273 37/137 (27%)
HisZ <1141..1397 CDD:226228 67/284 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 141 1.000 Domainoid score I2926
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H40891
Inparanoid 1 1.050 361 1.000 Inparanoid score I1279
Isobase 1 0.950 - 0 Normalized mean entropy S4325
OMA 1 1.010 - - QHG53068
OrthoDB 1 1.010 - - D433474at33208
OrthoFinder 1 1.000 - - FOG0004143
OrthoInspector 1 1.000 - - oto17995
orthoMCL 1 0.900 - - OOG6_102717
Panther 1 1.100 - - LDO PTHR11042
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2124
SonicParanoid 1 1.000 - - X3408
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.960

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