Protein Alignment Gcn2 and zyg-1

DIOPT Version :10

• Sequence 1: NP_001263142.1
• Gene: Gcn2 / 43709
• FlyBaseID: FBgn0019990
• Length: 1591
• Species: Drosophila melanogaster
• Sequence 2: NP_495103.1
• Gene: zyg-1 / 173956
• WormBaseID: WBGene00006988
• Length: 706
• Species: Caenorhabditis elegans
• Alignment Length: 732
• Identity: 143/732 - (19%)
• Similarity: 246/732 - (33%)
• Gaps: 289/732 - (39%)

  Fly   517 SQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNRE-YAIKRIPLPARSRQLYKKMTREVELLSRLN 580
            |.||| :.:..|..:|||.||.|...:.  :|.| .|||||.         ||:.:
 Worm     6 SGSRL-SAYSHLKEIGKGGFGVVYAAQR--ENGEKVAIKRID---------KKVPK--------- 49

  Fly   581 HENVVRYFNSWIESVDDADAAEMDKLLGGEWSQSQQDLSVKPAKSPQLGPTLEEDEDEEDSSSSM 645
              |.|                         |::.|....:|.:|
 Worm    50 --NRV-------------------------WTEIQTMKELKKSK--------------------- 66

  Fly   646 WNGYIPNMEDSDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSPKPLMQVMYIQMEFCEKCTLRT 710
               |:          :||         |:|..::..|              ||.||.||..:|:.
 Worm    67 ---YV----------VEF---------YEDFVEDGYT--------------YIVMELCEGGSLQA 95

  Fly   711 AIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFL-DSHDQ---IKIGDFGLATTS 771
            .:.::...|......:.|::...::.:|:..:|||||...|:|: ||..:   :|:||||||||
 Worm    96 YVREHGALDDATAVHVLRQLISAVSFMHRVNVIHRDLSAGNVFIKDSKKKKMTVKLGDFGLATT- 159

  Fly   772 FLALQAHDAAPAPVNQITSAEDGTGTGK-----VGTTLYVAPELTGNASKSVYNQKVDMYTLGII 831
                                   .|.|:     |||..::||::....    |.|..|:|:||.:
 Worm   160 -----------------------LGRGETTCTIVGTPGFIAPQVYDQE----YTQSADVYSLGAV 197

  Fly   832 LFEM----------CQPPFDTSMERAQTIMALRNVS----INIPDAMLKDPKYEKT--------- 873
            |:.|          ..|....|...|:.:..:.:..    |.:...:|.:..||.|
 Worm   198 LYTMLTARNPPPKGLPPTCGMSPNAARLVEQMMDTDAKKRIPLTQIVLSEFMYENTNENAVIFSR 262

  Fly   874 --------------VKMLQWLLNHD----------PA--------QRPTAEELLISD-------- 898
                          |:..:...:.|          ||        .||..:.:..:.
 Worm   263 EHSRDGRRQRSREPVRSSRDDRSRDGRALIRSSSQPAHSGRAPLSNRPIHDRMPSTSSRGFDSER 327

  Fly   899 -----------LVPPAQLEAN--------------------------ELQEMLRHALANPQSKAY 926
                       .|||::.:.|                          ||....|..:|     |.
 Worm   328 GRERDRDSGRGTVPPSREDRNRSQLWPIRMDRLEGQRVCTAGGRYIVELDTRCRFEVA-----AQ 387

  Fly   927 KNLVARCLQQESDEVLEHTY-HLGSSRAMKSWNSAIIIDDIVSL--NPVI----EFVKAKVVNLF 984
            .|.|.|.|..|.||:::..| |....|.::..|..   :::::|  ||.:    ..:..:|.|.:
 Worm   388 GNFVKRILIVEVDEMVQTVYVHRIPDRTVRGRNGE---EELITLTNNPFVYTSYSQMPKEVQNDY 449

  Fly   985 ---RKHGAIEVDSPLLSPLSARNSTANANANAVHLMTHSGCVVVLPCDL---------------- 1030
               :|..|:.: |..::.::.|..:...:|.| .||.:....:.||..:
 Worm   450 MRLQKMVAVTI-SGRVAKVTFRRPSQFPDAQA-QLMENGDLRIKLPRSVIVRKMDNGEIFNCIDG 512

  Fly  1031 ---RTQFARHVTMNSVNLIRRYCVDRVYREERVFNFHPKQSYDCSFDIIAPTTGSHLVDAELLSL 1092
               :.|....:|:..||.:.:|.:    |.|:..| ...:...| |.|:. :.|:::|.:...||
 Worm   513 IATQKQAVSGITLTKVNEVYKYLI----RFEQCLN-GMDRGMVC-FPIVF-SAGTNMVGSSPSSL 570

  Fly  1093 AFEITSELPRLREKNLA 1109
            ....:|:..|....||:
 Worm   571 MPSGSSQTSRFPFSNLS 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD_GCN2	11..131	CDD:467659
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	88/444 (20%)
		class_II_aaRS-like_core	974..>1137	CDD:444800	31/158 (20%)
		PRK12420	1029..1392	CDD:237097	19/100 (19%)
zyg-1	NP_495103.1	S_TKc	13..249	CDD:214567	76/367 (21%)
		Polo_box_2	351..460	CDD:408318	23/116 (20%)
		Polo_box_3	463..561	CDD:408331	19/105 (18%)