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Protein Alignment Gcn2 and Eif2ak1

DIOPT Version :10

Sequence 1:	NP_001263142.1	Gene:	Gcn2 / 43709	FlyBaseID:	FBgn0019990	Length:	1591	Species:	Drosophila melanogaster
Sequence 2:	NP_038585.2	Gene:	Eif2ak1 / 15467	MGIID:	1353448	Length:	619	Species:	Mus musculus

Alignment Length:	605	Identity:	174/605 - (28%)
Similarity:	267/605 - (44%)	Gaps:	137/605 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 DFSLVPNLLELLSGAGQSSSCGDLPALGALVESLM----------PTNSYEM-----RDFVD--- 458
            |.|.||..|::|....|..:...|.|...|:.||:          |.:|.::     :.|:.
Mouse    39 DESDVPAELQVLKEPLQQPTFPFLVANQLLLVSLLEHLSHVHEPNPLHSKQVFKLLCQTFIKMGL 103

  Fly   459 ----KCNSDRTLSASELLEHPFLRFYVDNGQQQVMPLPQQQHPNTVQRTGSAMPYQIPTLALSQS 519
                .|:.:  .|:..|..:..:...:.:.:::|...|.|.:....:.....:.::..|     |
Mouse   104 LSSFTCSDE--FSSLRLHHNRAITHLMRSAKERVRQDPCQDNSYMQKIRSREIAFEAQT-----S 161

  Fly   520 RLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENV 584
            |...|||.|..||||.:|.|.||||.||.:.||||:|.:.:.::....|:.|||::|:.|.|.|:
Mouse   162 RYLNEFEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGLQHPNI 226

  Fly   585 VRYFNSWIE----------------SVDDADAAEMDKLLGG----EWSQSQQDLSVKPAKSPQLG 629
            |.|..:|||                |::.....|.|:..||    |.|.|.....:.|.|....|
Mouse   227 VGYHTAWIEHVHVVQPQDRVPIQLPSLEVLSEQEGDRDQGGVKDNESSSSIVFAELTPEKEKPFG 291

  Fly   630 PTLEEDEDEEDSSSSMWNGYIPNMEDSDS------DGIEFVDSNGKVAV---------------- 672
            .: |...:..:..|...|..:.|..:|:|      ||:  .|.:.:..|
Mouse   292 ES-EVKNENNNLVSYTANLVVRNSSESESSIELQEDGL--TDLSVRPVVRHQLPLGHSSELEGNF 353

  Fly   673 -YDDEEQEDSTR--GKTNSPKPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLW---------- 724
             ..||..|.:..  |:|.....||  ::|||:.|| .:|...|.:.  |...|.:
Mouse   354 TSTDESSEGNLNLLGQTEVRYHLM--LHIQMQLCE-LSLWDWITER--NKRSREYVDEAACPYVM 413

  Fly   725 -----RLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHD-QIKIGDFGLATTSFLALQAHDAAPA 783
                 ::|:|:.||:.:||..||:||||||.||||...| |:||||||||....:.
Mouse   414 ASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACADIIQ--------- 469

  Fly   784 PVNQITSAEDGTG----TGKVGTTLYVAPE-LTGNASKSVYNQKVDMYTLGIILFEMCQPPFDTS 843
              |...:..:|.|    |.:|||.||.:|| |.|    |.|:.|.|||:||:||.|:.| ||.|.
Mouse   470 --NADWTNRNGKGTRTHTSRVGTCLYASPEQLEG----SQYDAKSDMYSLGVILLELFQ-PFGTE 527

  Fly   844 MERAQTIMALRNVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDL--------- 899
            ||||..:..:|  :..||:::.|  :.....|.:|.|...:.:|||:|.:||.|:|
Mouse   528 MERATVLTGVR--TGRIPESLSK--RCPVQAKYIQLLTGRNVSQRPSALQLLQSELFQTTGNVNL 588

  Fly   900 -----VPPAQLEANELQEML 914
                 :...:.|..||::.|
Mouse   589 TLQMKIIEQEKEIEELKKQL 608

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.