Protein Alignment Gcn2 and Hars1

DIOPT Version :10

• Sequence 1: NP_001263142.1
• Gene: Gcn2 / 43709
• FlyBaseID: FBgn0019990
• Length: 1591
• Species: Drosophila melanogaster
• Sequence 2: NP_032240.3
• Gene: Hars1 / 15115
• MGIID: 108087
• Length: 509
• Species: Mus musculus
• Alignment Length: 567
• Identity: 119/567 - (20%)
• Similarity: 225/567 - (39%)
• Gaps: 137/567 - (24%)

  Fly   910 LQEMLRHALANPQSKAYKNLVARCLQQESDEVLEHTYHLGSSRAMKSWNSAIIIDDIVSLNP--- 971
            |:|::|...|:.:....:...|..:::|..::|:....||.....:.:         |...|
Mouse     7 LEELVRLQGAHVRGLKEQKASAEQIEEEVTKLLKLKAQLGQDEGKQKF---------VLKTPKGT 62

  Fly   972 ---------VIEFVKAKVVNLFRKHGAIEVDSPLLSPLSARNSTANANANAVH-LMTHSGCVVVL 1026
                     |.|.|...::..|::|||..:|:|:.............::..:: |....|.::.|
Mouse    63 RDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLTGKYGEDSKLIYDLKDQGGELLSL 127

  Fly  1027 PCDLRTQFARHVTMNSVNLIRRYCVDRVYREERVFNFHP-------KQSYDCSFDIIAPTTGSHL 1084
            ..||...|||::.||.:..|:||.:.:|||.:     :|       ::.|.|.|| ||......:
Mouse   128 RYDLTVPFARYLAMNKLTNIKRYHIAKVYRRD-----NPAMTRGRYREFYQCDFD-IAGQFDPMI 186

  Fly  1085 VDAELLSLAFEITSELPRLREKNLAIRMNHTNLLRAILIFCNVPKAQYGALF------------- 1136
            .|||.|.:..||.|.   |:..|..:::|...:|..:...|.||.:::..:.
Mouse   187 PDAECLKIMCEILSS---LQIGNFLVKVNDRRILDGMFAVCGVPDSKFRTICSSVDKLDKVSWEE 248

  Fly  1137 --------EGTMDFIESRISRF-QFHSSITGI--------MEKSRTSAQTLMDM-LLANFLLTGS 1183
                    :|....:..||..: |.|..::.:        :.:::.:.:.|.|: ||..:|:...
Mouse   249 VKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQAVEGLGDLKLLFEYLILFG 313

  Fly  1184 RSTVDDSALKSLMRGKGEAASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASNGGIV 1248
               :||.....|        |||||    |:...|:.|.                       .::
Mouse   314 ---IDDKISFDL--------SLARG----LDYYTGVIYE-----------------------AVL 340

  Fly  1249 WQMTADLKPNRSGHPSV----LAIGERYDSMLHEFQKQAQKFNPAMPARGVLSGAGLTFSL--DK 1307
            .||     |.::|...:    :|.|.|||.::..|..:.:|    :|..|:..|....||:  .:
Mouse   341 LQM-----PTQAGEEPLGVGSIAAGGRYDGLVGMFDPKGRK----VPCVGLSIGVERIFSIVEQR 396

  Fly  1308 LVAAVGVEYAKDCRAIDVGICVCGTRPP-LKDVTYIMRLLWSVGIRCGIV-EAASELGDEAQDLA 1370
            |.|:     .:..|..:..:.|...:.. |::...::..||..||:..:: :...:|.::.|...
Mouse   397 LEAS-----EEKVRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCE 456

  Fly  1371 RLGALHVILVAE----NGSLRVRSF-ERERFQERHLTRTELVEFIQK 1412
            ..|...|.::.|    :|.:::||. .||....|   |.:|||.|::
Mouse   457 EAGIPLVAIIGEQELKDGVIKLRSVASREEVDVR---REDLVEEIRR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD_GCN2	11..131	CDD:467659
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948
		class_II_aaRS-like_core	974..>1137	CDD:444800	45/191 (24%)
		PRK12420	1029..1392	CDD:237097	88/413 (21%)
Hars1	NP_032240.3	HisRS_RNA	5..49	CDD:238474	9/41 (22%)
		PLN02972	<57..505	CDD:215525	109/508 (21%)