Protein Alignment Gcn2 and Gcn2

DIOPT Version :10

• Sequence 1: NP_001263142.1
• Gene: Gcn2 / 43709
• FlyBaseID: FBgn0019990
• Length: 1591
• Species: Drosophila melanogaster
• Sequence 2: XP_061511700.1
• Gene: Gcn2 / 1280343
• VectorBaseID: AGAMI1_005912
• Length: 1661
• Species: Anopheles gambiae
• Alignment Length: 1732
• Identity: 801/1732 - (46%)
• Similarity: 1089/1732 - (62%)
• Gaps: 221/1732 - (12%)

  Fly     7 KESFRERQAQELEVIKSIFGCDVEDLRPQANPSLWKPTDIRIQLTPLRDSSNGLETYVCTKLHVT 71
            ||:.||||..|||||||||..:||||||:...  |||.::|:.|||.|.|:.  |.||...|:||
Mosquito     4 KETIRERQENELEVIKSIFHDEVEDLRPRTGK--WKPLELRLHLTPQRGSAK--EAYVKADLYVT 64

  Fly    72 CPSKYPKLPPKISLEESKGMSDQLLEALRNQLQAQSQELRGEVMIYELAQTVQAFLLEHNKPPKG 136
            |..||||.|||:.|:.:.|:||.|:..|..:|:..:.||:|||||:|||.||||||.:||.||||
Mosquito    65 CSPKYPKCPPKLELKHAVGLSDSLVRELTEKLEQLADELKGEVMIFELANTVQAFLHQHNVPPKG 129

  Fly   137 SFYDQMLQDKQKRDQELQDIQRQRESLQRQTLIDEVERRKEMFKTEAKRRGEPRRSMSESNPRHP 201
            ||||:||.::||:....|:..:..|:|:||.:.||::|||:  :.|..|| |.|.|.:||:|.|.
Mosquito   130 SFYDEMLANQQKQALARQNTLQAEETLKRQAIQDELQRRKK--ELERTRR-ESRHSTNESSPMHR 191

  Fly   202 -SSSESSENSSPYYRGHIYPSKCLDHRNTETLYFHKMGRQIQRGCCVGEGHSQRGCIAYTGIDMH 265
             .||.|:|||...|        |::||.:|.||| :.||::.||.|:  ||||||||||.|||..
Mosquito   192 LHSSSSTENSDGAY--------CVEHRRSEVLYF-RDGRKVLRGSCL--GHSQRGCIAYAGIDQQ 245

  Fly   266 CGQLLYITEWNIKYSQLEQPCIGGGKCHWSSESKCMGSHRVDEVMASIEKQVSSLSQLQHKNLVS 330
            .|:|:|:|||.:.|.         |:|  |:||:.:....|:.|:..:|:....|..|:||:|::
Mosquito   246 TGELVYLTEWTLYYD---------GEC--SAESRTIRGRPVETVVGEMERLADGLIPLKHKHLIA 299

  Fly   331 YECVLCIKRKEGLLVYLVQDFLLGTSVFSISSSLGWCMDGARMVARGVLDALVFLHNKGVSHSHL 395
            ||.|||...||.|.:::||:|:||||:||||.||||.::||.|||:|.|:||::|||.||||.:|
Mosquito   300 YEGVLCRMGKEALTLFVVQEFILGTSLFSISGSLGWSVEGASMVAKGTLEALIYLHNNGVSHDNL 364

  Fly   396 LDTTVFMDNTGNVRVSDFSLVPNLLELLSG---AGQSSSCGDLPALGALVESLMPTNSYEMRDFV 457
            .|:||||||.|.|||:||.|:|.:.||...   ..||....|||:||.|:|:|:..:| ||:|||
Mosquito   365 SDSTVFMDNAGMVRVADFRLIPYIQELSDSQHLLHQSLRSPDLPSLGGLIEALLAPHS-EMKDFV 428

  Fly   458 DKCNSDRTLSASELLEHPFLRF-------YVDNGQQQVMPLPQQQ---HPNTV-QRTGSAMPYQ- 510
            ::|.|:||:||:|||:|||||.       :|..||||:.....|:   .|.|| ||:.:....|
Mosquito   429 ERCKSERTISATELLDHPFLRSTLLLHTDHVAMGQQQLTAAALQKALPAPTTVGQRSENGQQQQL 493

  Fly   511 ----IPTLAL---------SQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARS 562
                :|.:.|         .:||::||||:|.||||||:||||||||.|||||||||||.|||||
Mosquito   494 QQQLVPYMPLVMNGSGTGQEKSRIQTEFELLSYLGKGAYGDVLKVRNKLDNREYAIKRIRLPARS 558

  Fly   563 RQLYKKMTREVELLSRLNHENVVRYFNSWIESVDDAD---AAEMD-KLLGG------EWSQSQQ- 616
            :|.||||||||||||||||||||||:|||:|:...|:   |.:.: ::.||      :||.:.:
Mosquito   559 KQFYKKMTREVELLSRLNHENVVRYYNSWVEATSTAEMLAATDTEGEMAGGGTVSSCDWSVASRP 623

  Fly   617 -----------------DLSVKPAKSPQL---------GPTLEEDEDEED-------------SS 642
                             ||..|..:...:         ..:.||||||||             ||
Mosquito   624 KRRASRVRRTTATAAAADLVKKGIEDKNIDCFVDFLPNDTSSEEDEDEEDDDETNDLDEDSSSSS 688

  Fly   643 SSMWNGYIPN----MEDSDSD---GIEFVDSNGKVAVYDDEEQEDST-------RGKTNSPKPLM 693
            |...:|.|.|    .|:|.:|   |||||.|||:...|:...:..|.       :..|....|.:
Mosquito   689 SDESSGSISNHRKLNEESFNDSSGGIEFVGSNGEAPSYNSYGEAGSAVENGGGKKAATTPAPPEV 753

  Fly   694 QVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHD 758
            ..||||||||||.|||||||..|:.|.||:|||||||.|||:||||||:||||||||||||||.|
Mosquito   754 LYMYIQMEFCEKSTLRTAIDAGLYQDIDRVWRLFREIVEGLSHIHQQGMIHRDLKPVNIFLDSRD 818

  Fly   759 QIKIGDFGLATTSFLAL--QAH-DAAP--------APVNQITSAEDGTG-TGKVGTTLYVAPELT 811
            |:|||||||||||.|||  |.| :|.|        |.:.|..|::.|.. ||||||.||||||||
Mosquito   819 QVKIGDFGLATTSILALQNQGHQNATPGQMGHLAVASIQQGKSSDIGYSLTGKVGTALYVAPELT 883

  Fly   812 GNASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKDPKYEKTVKM 876
            ||||:|.||||||:|:||||||||...|.:|.|||.:|:|.||:.:|.:|:|:|.|.:|.:.|::
Mosquito   884 GNASRSTYNQKVDLYSLGIILFEMSSQPLNTGMERVKTLMDLRSDAIRLPEALLTDARYSRLVQV 948

  Fly   877 LQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQEMLRHALANPQSKAYKNLVARCLQQESDEV 941
            ::|||||||.:||||||:|.|:|||..:|||.|:|:::||.|:||||:.||:|:|||..|.||.:
Mosquito   949 IRWLLNHDPQKRPTAEEVLCSELVPRTRLEAEEIQDVVRHILSNPQSRHYKHLIARCFAQASDPI 1013

  Fly   942 LEHTYHLGSSRAMKSWNSAIIIDDIVSLNPVI---EFVKAKVVNLFRKHGAIEVDSPLLSPLSAR 1003
            .|.:||.                |:|.:.|::   ::||||:|.||||||||||.:|||:|.:.:
Mosquito  1014 CELSYHF----------------DMVPMIPILPRFDYVKAKLVALFRKHGAIEVVTPLLTPYTKQ 1062

  Fly  1004 NSTANANANAVHLMTHSGCVVVLPCDLRTQFARHVTMNSVNLIRRYCVDRVYREERVFNFHPKQS 1068
            ::   |.:|.|.||||||.||.||.|||..|.||:.:|.:..||||.:.|||||::||||||||.
Mosquito  1063 HA---ARSNTVKLMTHSGSVVTLPDDLRVPFLRHIALNGIKHIRRYSIGRVYREKKVFNFHPKQV 1124

  Fly  1069 YDCSFDIIAPTTGSHLVDAELLSLAFEITSELPRLREKNLAIRMNHTNLLRAILIFCNVPKAQYG 1133
            |:|:|||:.|:.|..:.|||||::|.::..||..|:.:|:..|:||..||||||:.||||..:|.
Mosquito  1125 YECAFDIVTPSRGHLITDAELLAIATDVMRELNLLQGRNVFFRLNHIGLLRAILMHCNVPMDKYR 1189

  Fly  1134 ALFEGTMDFIESRISRFQFHSSITGIM--EKSRTSAQTLMDML---LANFLLTGSRSTVDDSALK 1193
            .|||...:|::.:||:||..|.|..::  ..::.:...|.|.|   |::..|.|.      |.||
Mosquito  1190 ELFEMVAEFLDEKISKFQLSSLINSLIGGSAAKINVSFLCDALQLELSSVGLLGG------SILK 1248

  Fly  1194 SLMRGKGEAASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASNGGIVWQMTADLKPN 1258
            |::||||||||||:.|:|||||||.||.::||:||:::..|||::::||..||||||:..:|||.
Mosquito  1249 SIIRGKGEAASLAKVAVRELETVVTLAQNMGVQCPLNVCPGLPVNYERAKTGGIVWQLLGELKPK 1313

  Fly  1259 RSGHPSVLAIGERYDSMLHEFQKQAQKFNPAMPARGV-LSGAGLTFSLDKLVAAV----GVEYAK 1318
            |....:.:|:|.|||..|.||||..  .|..:....| |||||.:|.|||||.|:    |.|
Mosquito  1314 RKNPLTTIAVGGRYDGKLAEFQKSG--INNGLQVPKVDLSGAGFSFLLDKLVNAIAPTAGYE--- 1373

  Fly  1319 DCRAIDVGICVCGTRPPLKDVTYIMRLLWSVGIRCGIVE----AASELGDEAQDLARLGALHVIL 1379
               .|:|.|||.|:||..|:|...:|.|||..|:..:||    |..:||.||      ||..|:|
Mosquito  1374 ---PIEVMICVTGSRPQPKEVAQTLRPLWSNSIKTCVVETSAGAVDDLGKEA------GATVVVL 1429

  Fly  1380 VAENGSLRVRSFERERFQERHLTRTELVEFIQKMLRSDGLNGTTVDNFSQLSALGSGDNR----- 1439
            :.:.|.:||||:..:||||.|:||.||:.:|.:.||...::...:....|.::||.....
Mosquito  1430 LGDGGEMRVRSWNHDRFQELHVTRPELMPYILRTLRRSDVSTGELSQALQSTSLGGASTSASFSY 1494

  Fly  1440 -------SSGGKERERGENGLSTSASNATIKNNYSQLPNLQVTFLTHDKPTANYKRRLENQVAQQ 1497
                   ||....|..     |.|:|.|:.:.:.:..|.|.:.|||.:|...:.|||.|:||..:
Mosquito  1495 SSSFTAISSAASTRLS-----SASSSAASQQQSINTSPPLDLVFLTSEKINTSKKRRYEHQVEHK 1554

  Fly  1498 MSSTLSQFLKKETFVVLVVELPPAVVNAIVGAINPREIRKRETEP-----------EINYVIERF 1551
            ||..||:|.:||...:::|::|.|.:..:||.|:|.|...:|.:.           |:..:.||:
Mosquito  1555 MSPVLSKFHRKEKVTLIMVDVPSAPLRGLVGLIDPLECGSQEDDDDIPSGSTTDRVELQSLCERY 1619

  Fly  1552 SKYKRYISEINEEVVDYLSDAK--TPIVALYSISDSYYRVII 1591
            .||||.:.:|..|:||..:.:|  ||||.|||:.|::.|:|:
Mosquito  1620 PKYKRQLMQIYNEIVDLFAQSKGTTPIVGLYSVIDTFCRLIL 1661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gcn2	NP_001263142.1	RWD_GCN2	11..131	CDD:467659	65/119 (55%)
		PK_eIF2AK_GCN2_rpt1	261..476	CDD:270914	106/217 (49%)
		STKc_EIF2AK4_GCN2_rpt2	518..898	CDD:270948	241/455 (53%)
		class_II_aaRS-like_core	974..>1137	CDD:444800	88/162 (54%)
		PRK12420	1029..1392	CDD:237097	171/376 (45%)
Gcn2	XP_061511700.1	None