DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gcn2 and Eif2ak4

DIOPT Version :9

Sequence 1:NP_001263142.1 Gene:Gcn2 / 43709 FlyBaseID:FBgn0019990 Length:1591 Species:Drosophila melanogaster
Sequence 2:NP_001099214.2 Gene:Eif2ak4 / 114859 RGDID:1311439 Length:1649 Species:Rattus norvegicus


Alignment Length:1761 Identity:565/1761 - (32%)
Similarity:880/1761 - (49%) Gaps:305/1761 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 KESFRERQAQELEVIKSIFGCDVEDLRPQANPSLWKPTDIRIQLTPLRDSSNGLETYVCTKLHVT 71
            :||:.:||..||:.:::|:|.|.:||||.|...:.:|.:|.:.|.|  ....|.|.||..:|.|.
  Rat    16 QESYSQRQDHELQALEAIYGSDFQDLRPDARGRVREPPEINLVLYP--QGLAGEEVYVQVELRVK 78

  Fly    72 CPSKYPKLPPKISLEESKGMSDQLLEALRNQLQAQSQELRGEVMIYELAQTVQAFLLEHNKPPKG 136
            ||..||.:.|:|.|:.:||:|::.:..|::.|:..:::..|||||:|||..||:||.||||||..
  Rat    79 CPPTYPDVVPEIELKNTKGLSNESVNLLKSHLEELAKKQCGEVMIFELAHHVQSFLSEHNKPPPK 143

  Fly   137 SFYDQML----QDKQKRDQELQDIQRQRESLQRQTLIDEVERRKEMFKTEAKRRGEPRRSMSE-- 195
            ||:::||    |:||:|..|    .||:|..:::.::.|:::|||..|.|.||:...::...|  
  Rat   144 SFHEEMLERQAQEKQQRLLE----ARQKEEQEQREILHEIQKRKEEIKEEKKRKEMAKQERLEIT 204

  Fly   196 --SNPRHPS-----------------------------SSESSENSSPY--YRGHIYPSKCLDHR 227
              :|..|.|                             ||..|.....|  ..|...|..|    
  Rat   205 SLTNQDHASKRDPAGHRAAAILHGGSPDFVGNGKARAHSSGRSRRERQYSVCSGEASPGSC---- 265

  Fly   228 NTETLYFHKMGR----QIQRGCCVGEGHSQRGCIAYTGIDMHCGQLLYITEWNIKYSQLEQPCIG 288
              :.||| .:|.    .:.:|.||| ...|.|.:.|..::...|..:.:.||.:::.:...||: 
  Rat   266 --DILYF-CVGSADQLMVHKGKCVG-SDEQLGKVVYNALETATGSFVLLYEWVLQWQKKMGPCL- 325

  Fly   289 GGKCHWSSESKCMGSHRVDEVMASI---EKQVSSLSQLQHKNLVSYECVLCIKRKEGLLVYLVQD 350
                  :|:.|    .::|:....|   |.:.|||.:|.|.|:|.|..:...:.|:.::|.::.:
  Rat   326 ------TSQEK----EKIDKCKKQIQGAETEFSSLVKLSHPNIVRYFAMNSREEKDSIVVDILAE 380

  Fly   351 FLLGTSVFS-ISSSLGWCMDGARMVARGVLDALVFLHNKGVSHSHLLDTTVFMDNTGNVRVSDFS 414
            .:.|.|:.: :|.|....|...|.....:|..|.:||...|.|..|...:|.:|..|.|:::|:|
  Rat   381 HISGISLAAHLSHSGPVPMHQLRKYTAQLLAGLDYLHRNSVVHKVLSTASVLVDAEGTVKITDYS 445

  Fly   415 LVPNLLEL------------LSGAG---QSSSCGDLPALGALVESL------------MPTN-SY 451
            :...|.::            .|.:.   ::...||:..||.|:.||            :|:: ..
  Rat   446 ISKRLADICKEDVFEQTRVRFSDSALPYKTGKKGDVWRLGLLLLSLSQGQECEEYPVTIPSDLPA 510

  Fly   452 EMRDFVDKC---NSDRTLSASELLEHPFLRFYVDNGQQQVMPLPQQQHPNTVQRTGSAMPY---- 509
            :.:||:.||   :.....|..:||:|.|:      ..|..|||.:|...::     ....|    
  Rat   511 DFQDFLKKCVCLDDKERWSPQQLLKHSFI------NPQPKMPLVEQSPEDS-----GGQDYIETI 564

  Fly   510 ----QIPTLAL------SQSRLRTEFEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQ 564
                |:|:.|.      ..||...|||.|..|||||||.|:||:|.||...||:||||:...|||
  Rat   565 IPSNQLPSAAFFTETQRQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQ 629

  Fly   565 LYKKMTREVELLSRLNHENVVRYFNSWIE-----------SVDDADAAEMDKLLGGEWSQSQQDL 618
             ::::..||.|||||:|||:|||:|:|||           ..|....|:.....||:.|...::|
  Rat   630 -FRRIKGEVTLLSRLHHENIVRYYNAWIERHERPAVPGTPPPDYIPQAQNSSATGGKASGDTEEL 693

  Fly   619 -SVKPAKSPQLGPTL----------------------------EEDEDEEDSSSSMWNGYIPNME 654
             ||:.|..|   |.|                            ||||||.|...|  ..::| ..
  Rat   694 GSVEAAAPP---PILSSSVEWSTSAERSNSARFPVTGQDSSSDEEDEDERDGVFS--QSFLP-AS 752

  Fly   655 DSDSDGI-EFVDSNGKVAVYDDEEQEDSTRG--KTNSPKPLMQVMYIQMEFCEKCTLRTAIDDNL 716
            |||||.| :..|.|.|....|::..|..:|.  :.:.....:..:|||||:|||.|||..||..|
  Rat   753 DSDSDIIFDNEDENSKSQNQDEDCNEKDSRHEIEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGL 817

  Fly   717 FNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAH--- 778
            |.||.|||||||||.:|||:||::|:||||||||||||||.|.:|||||||| |..||..|.   
  Rat   818 FRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLA-TDHLAFNAEGKQ 881

  Fly   779 -DAAPAPVNQITSAEDGTGTGKVGTTLYVAPELTGNASKSVYNQKVDMYTLGIILFEMCQPPFDT 842
             |.|...|  |.|...|..||.|||.|||:||:.| ::||.||||||:::||||||||...|..|
  Rat   882 DDQAGDHV--IKSDPSGHLTGMVGTALYVSPEVQG-STKSAYNQKVDLFSLGIILFEMSYHPMVT 943

  Fly   843 SMERAQTIMALRN-VSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLE 906
            :.||...:..||: .|...||. .:|.::.|...::.||||||||:||||.|||.|:|:||.|:|
  Rat   944 ASERIFVLNQLRDPTSPKFPDD-FEDGEHTKQKSVISWLLNHDPAKRPTAMELLKSELLPPPQME 1007

  Fly   907 ANELQEMLRHALANPQSKAYKNLVARCLQQESDEVLEHTYHLGSSRAMKSWNSAIIIDDIVSLNP 971
            .:||.|:|.|.|||...|||:.::::...|.|...:::||.                .||:..|.
  Rat  1008 ESELHEVLHHTLANTDGKAYRTMMSQLFCQHSSPAIDYTYD----------------SDILKGNF 1056

  Fly   972 VIEFVKAK------VVNLFRKHGAIEVDSPLLSPLSARNSTANANANAVHLMTHSGCVVVLPCDL 1030
            :|...|.:      :|.:|::|||:::.:|||.|   ||.....:..|...|.|||.:|:||.||
  Rat  1057 LIRTAKIQQLVCETIVRVFKRHGAVQLCTPLLLP---RNRQIYEHNEAALFMDHSGMLVMLPFDL 1118

  Fly  1031 RTQFARHVTMNSVNLIRRYCVDRVYREERVFNFHPKQSYDCSFDIIAPTTGSHLVDAELLSLAFE 1095
            |..|||:|..|::..::|||::||:|..::..||||:..:|:|||:..|..|.|..||.:...:|
  Rat  1119 RVPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTANSSLPTAETIYTIYE 1183

  Fly  1096 ITSELPRLREKNLAIRMNHTNLLRAILIFCNVPKAQYGALFEGTMDFIESRISRFQFHSSITGIM 1160
            :..|.|.|:|:|.:|.:|||.||:|||:.|.:|:.:...::....|.:..:::|.:..:....:.
  Rat  1184 VIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYVILYDAVTEKLTRREVEAKFCNLS 1248

  Fly  1161 EKSRTSAQTLMDMLLANFLLTGSRSTVDD--SALKSLMRGKGEAASLARGALRELETVVGLAYSL 1223
            ..|.:..:      |..|:  ..:..:.|  ..:.||::.|...|.|.:.:|::||.||||...|
  Rat  1249 LSSNSLCR------LYKFI--EQKGDLQDLTPTINSLIKQKTGIAQLVKYSLKDLEEVVGLLKKL 1305

  Fly  1224 GVKCPIHIWAGLPISFDRASNGGIVWQMTADLKPNRSGHPSVLAIGERYDSMLHEFQKQAQKFNP 1288
            |||..:.|..||.....:  :.||::|..|..|..:...|.:||.|.|||.::.:| :..|...|
  Rat  1306 GVKLQVSINLGLVYKVQQ--HNGIIFQFLAFSKRRQRVVPEILAAGGRYDLLIPKF-RGPQALGP 1367

  Fly  1289 AMPARGVLSGAGLTFSLDKLVAAV---GVEYAKDCRAIDVGIC----VCGTRPPLKDVTYIMRLL 1346
                  |.:..|::.::||:.|||   |       ..:.|..|    |...:..:.....:.:.|
  Rat  1368 ------VPTAVGVSIAIDKIFAAVLNMG-------EPVTVSSCDLLVVSAGQMSMSRAINLTQKL 1419

  Fly  1347 WSVGIRCGIVEAASELGDEAQDLARLGAL-HVILVA--ENGSLRVRSFERERFQERHLTRTELVE 1408
            |:.||...|:...|:..:|.|:..|...: :|.||:  |...::|:|||:||..|:.:..::||:
  Rat  1420 WTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLESDLVD 1484

  Fly  1409 FIQKMLRSDGLNGTTVDNFSQLSALGSGDNRSSGGKERERGENGLSTSASNATIKNNYSQLPNL- 1472
            .:.:.||      |.|           ||         ||.....|.:.:..|:|.::|....| 
  Rat  1485 HVMQKLR------TKV-----------GD---------ERNFRDASDNLAVQTLKGSFSNASGLF 1523

  Fly  1473 ---------QVTFLTHDKPTANYKRRLENQVAQQMSSTLSQFLKKETFV-VLVVELPPAVV---- 1523
                     .|:.::.:|.:|:.:||.|.||..::.:||:...:|.:.: :|.|:||...:    
  Rat  1524 EIHGTTVVPTVSVISPEKLSASTRRRHEIQVQTRLQTTLANLHQKSSEIEILAVDLPKETILQFL 1588

  Fly  1524 ----NAIVGAINPREIRKRETEPEINYVIERFSKYKRYISEINEEVVDYLSDAKTPIVALYSISD 1584
                :|...|.|          ..:..::.|..| :||:..:.:|:.:...:.|..::.|||..|
  Rat  1589 SLEWDADEQAFN----------TTVKQLLSRLPK-QRYLKLVCDEIYNIKVEKKVSVLFLYSYRD 1642

  Fly  1585 SYYRVI 1590
            .|||::
  Rat  1643 DYYRIL 1648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gcn2NP_001263142.1 RWD 17..130 CDD:214735 44/112 (39%)
PK_eIF2AK_GCN2_rpt1 261..476 CDD:270914 57/249 (23%)
STKc_EIF2AK4_GCN2_rpt2 518..898 CDD:270948 196/427 (46%)
S_TKc 525..895 CDD:214567 191/417 (46%)
HisS 974..1414 CDD:223202 137/457 (30%)
class_II_aaRS-like_core 974..>1137 CDD:294192 64/168 (38%)
Eif2ak4NP_001099214.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 4/9 (44%)
RWD 26..137 CDD:214735 44/112 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..260 5/32 (16%)
Pkinase 289..539 CDD:278497 60/260 (23%)
PK_eIF2AK_GCN2_rpt1 299..538 CDD:270914 57/249 (23%)
STKc_EIF2AK4_GCN2_rpt2 583..999 CDD:270948 196/427 (46%)
S_TKc 590..1001 CDD:214567 194/422 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..785 33/128 (26%)
Histidyl-tRNA synthetase-like. /evidence=ECO:0000250|UniProtKB:Q9QZ05 1022..1493 150/519 (29%)
HisS 1050..1486 CDD:223202 141/462 (31%)
class_II_aaRS-like_core 1061..1385 CDD:294192 109/343 (32%)
HGTP_anticodon 1396..1486 CDD:294191 24/89 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166346294
Domainoid 1 1.000 208 1.000 Domainoid score I2757
eggNOG 1 0.900 - - E1_COG0124
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H40891
Inparanoid 1 1.050 737 1.000 Inparanoid score I567
OMA 1 1.010 - - QHG53068
OrthoDB 1 1.010 - - D433474at33208
OrthoFinder 1 1.000 - - FOG0004143
OrthoInspector 1 1.000 - - oto97850
orthoMCL 1 0.900 - - OOG6_102717
Panther 1 1.100 - - LDO PTHR11042
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3408
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

Return to query results.
Submit another query.