DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt1a6a

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_659545.2	Gene:	Ugt1a6a / 94284	MGIID:	2137698	Length:	531	Species:	Mus musculus

Alignment Length:	550	Identity:	142/550 - (25%)
Similarity:	248/550 - (45%)	Gaps:	86/550 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVCLLPGYSE---------------GARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYP 56
            :.||||....               |.::|.| | ...||:......::.|:..||:|.
Mouse     1 MACLLPAAQTLPAGFLFLVLWASVLGDKLLVV-P-QDGSHWLSMKEIVEHLSERGHDIM------ 57

  Fly    57 QREPFRNIHDIPVPEVFENFNEVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNEGV-RRDILGP 120
                      :.||||    |.:|..:...|....|..:..|.:....:|..||..: ...::||
Mouse    58 ----------VLVPEV----NLLLGESKYYRRKIFSVTYSLEELQTRFRTFGNNHFLPGASLMGP 108

  Fly   121 QKPH-FDLVIMDLW--------------------RMDVLSG---------LAAYFDAPIIGMASY 155
            .:.: .:::::|::                    :.|.|..         ||.|.:.|.:.:..
Mouse   109 LREYRNNMIVVDMFFSNCQSLLKDSATLSFLRENKFDALFTDPAMPCGVILAEYLNLPSVYLFR- 172

  Fly   156 GTDWKIDELMG-NVSPISYLQSPSSRFYDLEAYGERL----LHLMERTFSYMNYKWRHVRKQETL 215
            |....::.::| :.||:||:....::|.|...:.:||    ::::|....|..|.     |.|.:
Mouse   173 GFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILENYLYYCLYS-----KYEII 232

  Fly   216 YSQFFPSVAERKPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFI 280
            .|...........|.:.|    |.|:...|....|||.:||||.:||::.....: |:.|.:.::
Mouse   233 ASDLLKRDVSLPSLHQNS----LWLLRYDFVFEYPRPVMPNMIFLGGINCKKKGK-LTQEFEAYV 292

  Fly   281 QGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQ 345
            ..:||.|::.||||:.|  ..:.|.:...:.|....:||.::|::..........|..:.||.||
Mouse   293 NASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQ 355

  Fly   346 QAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEE 410
            ..:|.||..:.||||.|.....|.|.:|.||:.:|...||..|...:...|.|:.||:.:||:::
Mouse   356 NDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADD 420

  Fly   411 FRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYH 475
            ..:.:..::.|||::|.....::.::|:|::|::.|::|.|||:.||||.|::.|..||.:.:||
Mouse   421 LENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYH 485

  Fly   476 SLDVFGTFLVGALVILGIVTYLLVMTLRKC 505
            ||||.|..|...|.::.||........|||
Mouse   486 SLDVIGFLLAIVLTVVFIVFKCCAYGCRKC 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	124/505 (25%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	133/511 (26%)
Ugt1a6a	NP_659545.2	egt	15..503	CDD:223071	133/522 (25%)
Ugt1a6a	NP_659545.2	UDPGT	27..522	CDD:278624	136/523 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840671
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690