Protein Alignment Ugt35D1 and UGT2A3

DIOPT Version :10

• Sequence 1: NP_651866.1
• Gene: Ugt35D1 / 43708
• FlyBaseID: FBgn0051002
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 158/563 - (28%)
• Similarity: 282/563 - (50%)
• Gaps: 86/563 - (15%)

  Fly     4 IFLLV---CLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEIT-------SVSPY--P 56
            :|||:   |:..|:.  .::| |:|. ..||:......|:.|...|||:|       |:..|  |
Human     9 VFLLLQLFCVGCGFC--GKVL-VWPC-DMSHWLNVKVILEELIVRGHEVTVLTHSKPSLIDYRKP 69

  Fly    57 QREPFRNIHDIPVPEVFENFNEV---LRIASTP-RSTWQSSDFINEYVLNLTKTV-------LNN 110
            ....|..:|   :|:.....||:   |.:...| .|||||...:|::.:.:..|:       :.|
Human    70 SALKFEVVH---MPQDRTEENEIFVDLALNVLPGLSTWQSVIKLNDFFVEIRGTLKMMCESFIYN 131

  Fly   111 EGVRRDILGPQKPHFDLVIMD--LWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGNV-SPIS 172
            :.:.:.:   |:.::|::::|  :...|:::.|.|   .|.:..........::...|.: :|:|
Human   132 QTLMKKL---QETNYDVMLIDPVIPCGDLMAELLA---VPFVLTLRISVGGNMERSCGKLPAPLS 190

  Fly   173 YLQSPSSRFYDLEAYGER--------LLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPL 229
            |:..|.:...|...:.||        |.|...:.:.|  :.|      |..||:   ::.....|
Human   191 YVPVPMTGLTDRMTFLERVKNSMLSVLFHFWIQDYDY--HFW------EEFYSK---ALGRPTTL 244

  Fly   230 SEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALS------AELDHFIQGAGESGV 288
            .|.....::.|:..::....|:||.||...|||||. ...:||.      .|:::|:|.:||.|:
Human   245 CETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHC-KPAKALPKINFYLQEMENFVQSSGEDGI 308

  Fly   289 IYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPP-----NVFISKWFPQQAI 348
            :.||||:  ..::::|::..::....|.:||:::|:::     ||.|     |..:..|.||..:
Human   309 VVFSLGS--LFQNVTEEKANIIASALAQIPQKVLWRYK-----GKKPSTLGANTRLYDWIPQNDL 366

  Fly   349 LAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRS 413
            |.||..|.||||||:....|:|:||.||:|:|...||..|:.|::..|..:.:|.|.||||:...
Human   367 LGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLR 431

  Fly   414 TIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLD 478
            .:..::|:.|::|.|...:..:.|||:||::.|::|.|:|:.||||.|::.|..||.:.:::|:|
Human   432 ALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSID 496

  Fly   479 VFGTFLVGALVILGIVTYLLVMTLRKCLFLIKRGKCEAIKKIQ 521
            |.| ||:..     :.|.:.:.|  || ||....|....:||:
Human   497 VIG-FLLAC-----VATAIFLFT--KC-FLFSCQKFNKTRKIE 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	GT1_Gtf-like	18..449	CDD:340817	127/472 (27%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	151/542 (28%)