DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt2a6

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001138283.1	Gene:	ugt2a6 / 797211	ZFINID:	ZDB-GENE-081104-3	Length:	529	Species:	Danio rerio

Alignment Length:	546	Identity:	148/546 - (27%)
Similarity:	261/546 - (47%)	Gaps:	76/546 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLVCLL-----PGYSEGARILAVFPLPSS-SHYFFALPYLKSLASLGHEIT-------SVSPYPQ 57
            ||||||     .|:|  .|:|.   :|.. ||:....|.:::|....|.:|       ...|:.|
Zfish     6 LLVCLLLCGVDVGWS--GRVLV---MPGEYSHWHNMRPVIEALVDKNHSVTVLVGSSSPTVPHTQ 65

  Fly    58 REPFR------------------NIHDIPVPEVFENFNEVLRIASTPRSTWQSSDFINEYVLNLT 104
            :|.|.                  :.|::.:.|....:.:.|.:       ||.......:...|.
Zfish    66 KERFEYHVFKVNMEKEVVDYLWIHFHELWMNETISTYEKTLEV-------WQLMSLFRAHSEELV 123

  Fly   105 KTVLNNEGVRRDILGPQKPHFDLVIMDLWRMDVLSGLAAYFDAP-IIGM-ASYGTDWKIDELMGN 167
            |. |.:.|:.:.:   :..::|::..|| .|.....:|...:.| ::.| .|:.:  .::.|.|.
Zfish   124 KG-LFDVGLLKTL---RDSNYDVLFSDL-TMPFSDLMAQKLNIPHVLSMRISFAS--ALERLCGQ 181

  Fly   168 VS-PISYLQSPSSRFY--DLEAYGER----LLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAE 225
            :. |.||:.:..::.:  |..::.||    ||::.......:..|:..    :.:|::.   ..|
Zfish   182 MPVPQSYVPAAVAQGHLTDRMSFTERVENMLLYITHTAMFQLTTKFTF----DHIYAEI---SGE 239

  Fly   226 RKPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIY 290
            ...:.|.....|:.|:..::....|||:.||...||||.. ...:.|:.||:.|:|.:|:.|::.
Zfish   240 PTTMCETIGKTDIWLIRTYWDFEYPRPFPPNFKFVGGLQC-KPAKPLAKELEEFVQSSGDHGIVV 303

  Fly   291 FSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVK 355
            ||||:.:  |:|:..:...:......:.|::||::..:......||..|..|.||..:|.||..|
Zfish   304 FSLGSMI--KNLTVQKANTIAAALGQISQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTK 366

  Fly   356 LFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLT 420
            .||||||.....|:|:||.||:|||...||..|:.|::..|..:||:...:.|::....:..:|.
Zfish   367 AFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLMHLKSKGAAVVLDFFTLESKDLVDALKTVLN 431

  Fly   421 NKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLV 485
            |.|::|:....:..:.||||||::.|::|.|:|:.:|||.|::|...:|.:.:||.||| ..||
Zfish   432 NPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDV-AAFL- 494

  Fly   486 GALVILGIVTYLLVMTLRKCLFLIKR 511
              |.|..::|:|.|   :.|.||.:|
Zfish   495 --LSITALITFLWV---KACCFLFRR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	129/495 (26%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	136/514 (26%)
ugt2a6	NP_001138283.1	UDPGT	21..519	CDD:278624	140/529 (26%)
ugt2a6	NP_001138283.1	egt	<254..485	CDD:223071	79/233 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585011
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55988
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.830