DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt2b6

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001170806.2	Gene:	ugt2b6 / 792506	ZFINID:	ZDB-GENE-100402-4	Length:	527	Species:	Danio rerio

Alignment Length:	551	Identity:	147/551 - (26%)
Similarity:	261/551 - (47%)	Gaps:	69/551 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPIFLLVCLLPGYSEG--ARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSP--------- 54
            |.|:...:.||...|.|  ..:|..|  ...||:......|::|...||::|.:.|
Zfish     1 MRPLACFLSLLSLLSAGECGNVLVWF--TEGSHWINMKIVLETLIDRGHDVTVLVPDASLFMKAN 63

  Fly    55 ------YPQREPFRNIHDIPVPEVF-ENF-------NEVLRIASTPRSTWQSSDFINEYVLNLTK 105
                  |   :||....|....:|| |.|       .:.|.........::.:..:.:..::...
Zfish    64 ASDRFSY---QPFNVSMDEQEMKVFIEEFLYFSLYEMDQLNFFQMQSKVYEFTSKLQDMSISYCD 125

  Fly   106 TVLNNEGVRRDILGPQKPHFDLVIMD-LWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGNV- 168
            .||.:.|:...:   :|..||:|..| :::...:  :|...:.|::....:......:.:.|.:
Zfish   126 GVLKSPGLLDKL---RKHKFDVVFSDPIYQCSDI--VAEELNVPLVYTFRFSLAHAAERMCGQIP 185

  Fly   169 SPISYLQSPSSRFYDLEAYGER----LLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPL 229
            :|.||:....|:..|..::.||    |.:|.:..|:.  :.|   :|.:..|:::|     .:|.
Zfish   186 APPSYVPGAMSKLTDKMSFTERIYNMLFYLSQDAFAI--FAW---KKIDNYYTEYF-----GRPT 240

  Fly   230 S--EISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFS 292
            |  |:....|:.|:..::....|||:|||...:||||.. ..:.|..:::.|:|.:||.|::.|:
Zfish   241 SYCEMMGRADIWLIRTYWDFEFPRPFVPNFKYIGGLHCT-PAKPLPKDMEEFVQSSGEDGIVVFT 304

  Fly   293 LGTNVKS--KSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKP----PNVFISKWFPQQAILAH 351
            ||:.|..  |.:|..    :....|.:||:::|::..|    ||    .|..|.||.||..:|.|
Zfish   305 LGSLVGKVPKEISNR----IASALAQIPQKVLWRYGGE----KPDTLGENTRIYKWIPQNDLLGH 361

  Fly   352 PNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVL-NIKQMTSEEFRSTI 415
            |..:.||||||.....|:|:||.||:|:|...||..||.|:...|..:|: :||.|..:|....:
Zfish   362 PKTRAFITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDSIKSMQPQELVDKL 426

  Fly   416 IRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVF 480
            ..::.:.|::|.|...:..:.|:||||::.:::|.|:|:.:|||.|::|...:|.:.:||.||||
Zfish   427 NTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVF 491

  Fly   481 GTFLVGALVILGIVTYLLVMTLRKCLFLIKR 511
            ........::|.|...:....:.:|.|..||
Zfish   492 AFLTTVLTLVLYICFKMAKFFIMRCCFRSKR 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	132/500 (26%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	137/518 (26%)
ugt2b6	NP_001170806.2	UDPGT	20..523	CDD:278624	141/532 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55988
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930