DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and UGT8

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001121646.2	Gene:	UGT8 / 7368	HGNCID:	12555	Length:	541	Species:	Homo sapiens

Alignment Length:	538	Identity:	143/538 - (26%)
Similarity:	255/538 - (47%)	Gaps:	59/538 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PIFLLVCLLPGYSEGARILAVFPLPSSSH-YFFALPYLKSLASLGHE--------------ITSV 52
            |.|:|:....|.::.|:|:.|.|:...|| |.|     |:|||..||              |...
Human     6 PYFILLWSAVGIAKAAKIIIVPPIMFESHMYIF-----KTLASALHERGHHTVFLLSEGRDIAPS 65

  Fly    53 SPYP-QREPFRNIHDIPVPEVFENFNEVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNEGVRRD 116
            :.|. ||.|  .|.:....:.|.. :::..|.|...:..:..|.::.|..|....|.|:..::
Human    66 NHYSLQRYP--GIFNSTTSDAFLQ-SKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQ-- 125

  Fly   117 ILGPQKPHFDLVIMDLWRMDVLSGLAAYFDAPIIGM--ASYGTDWKIDELMGNVSPISYLQSPSS 179
              |.:|..|||:::|      .:.:..:..|.::|:  |.:.|.......:|..:|::|:...:|
Human   126 --GLKKEKFDLLLVD------PNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNS 182

  Fly   180 RFYDLEAYGERLLHLMERT----FSYMNYKWRHVRKQETLYSQFFPSVAERKPLSEISRNFDLVL 240
            ...|    ...||..|:.|    .|.:...:..:.|.|.:..::  ::...|.:.::.....|.:
Human   183 LLTD----RMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKY--NLLPEKSMYDLVHGSSLWM 241

  Fly   241 VNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSED 305
            :.....|..|||.:||::.|||: :......|..:|..::.||.|.|.:..|.|..|  |.||||
Human   242 LCTDVALEFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVNGANEHGFVLVSFGAGV--KYLSED 303

  Fly   306 RRKVLLETFASLPQRIVWKFEDELLPGKPP-----NVFISKWFPQQAILAHPNVKLFITHGGLLS 365
            ....|......|||:::|:|.     |..|     |..:.:|.||..:|.|..:|.|::||||.|
Human   304 IANKLAGALGRLPQKVIWRFS-----GPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNS 363

  Fly   366 TIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARI 430
            ..|:|:||.|::|:|...|.:..|..|:..|:|::|..|.:|.:|....:::::.|.|:.:.|:.
Human   364 IFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQK 428

  Fly   431 TAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVT 495
            .:..::|||..|:...|:|.:|::.|.||.|::.|...:.|.:|..||:....|:||.::..:::
Human   429 LSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLS 493

  Fly   496 YLLVMTLRKCLFLIKRGK 513
            ::.....||...|..|.|
Human   494 WVTKFIYRKIKSLWSRNK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	129/485 (27%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	133/507 (26%)
UGT8	NP_001121646.2	Glycosyltransferase_GTB-type	21..502	CDD:415824	134/512 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150669
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8458
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.740