Protein Alignment Ugt35D1 and UGT8

DIOPT Version :10

• Sequence 1: NP_651866.1
• Gene: Ugt35D1 / 43708
• FlyBaseID: FBgn0051002
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_003351.3
• Gene: UGT8 / 7368
• HGNCID: 12555
• Length: 541
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 143/538 - (26%)
• Similarity: 255/538 - (47%)
• Gaps: 59/538 - (10%)

  Fly     3 PIFLLVCLLPGYSEGARILAVFPLPSSSH-YFFALPYLKSLASLGHE--------------ITSV 52
            |.|:|:....|.::.|:|:.|.|:...|| |.|     |:|||..||              |...
Human     6 PYFILLWSAVGIAKAAKIIIVPPIMFESHMYIF-----KTLASALHERGHHTVFLLSEGRDIAPS 65

  Fly    53 SPYP-QREPFRNIHDIPVPEVFENFNEVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNEGVRRD 116
            :.|. ||.|  .|.:....:.|.. :::..|.|...:..:..|.::.|..|....|.|:..::
Human    66 NHYSLQRYP--GIFNSTTSDAFLQ-SKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQ-- 125

  Fly   117 ILGPQKPHFDLVIMDLWRMDVLSGLAAYFDAPIIGM--ASYGTDWKIDELMGNVSPISYLQSPSS 179
              |.:|..|||:::|      .:.:..:..|.::|:  |.:.|.......:|..:|::|:...:|
Human   126 --GLKKEKFDLLLVD------PNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNS 182

  Fly   180 RFYDLEAYGERLLHLMERT----FSYMNYKWRHVRKQETLYSQFFPSVAERKPLSEISRNFDLVL 240
            ...|    ...||..|:.|    .|.:...:..:.|.|.:..::  ::...|.:.::.....|.:
Human   183 LLTD----RMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKY--NLLPEKSMYDLVHGSSLWM 241

  Fly   241 VNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSED 305
            :.....|..|||.:||::.|||: :......|..:|..::.||.|.|.:..|.|..|  |.||||
Human   242 LCTDVALEFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVNGANEHGFVLVSFGAGV--KYLSED 303

  Fly   306 RRKVLLETFASLPQRIVWKFEDELLPGKPP-----NVFISKWFPQQAILAHPNVKLFITHGGLLS 365
            ....|......|||:::|:|.     |..|     |..:.:|.||..:|.|..:|.|::||||.|
Human   304 IANKLAGALGRLPQKVIWRFS-----GPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNS 363

  Fly   366 TIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARI 430
            ..|:|:||.|::|:|...|.:..|..|:..|:|::|..|.:|.:|....:::::.|.|:.:.|:.
Human   364 IFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQK 428

  Fly   431 TAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVT 495
            .:..::|||..|:...|:|.:|::.|.||.|::.|...:.|.:|..||:....|:||.::..:::
Human   429 LSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLS 493

  Fly   496 YLLVMTLRKCLFLIKRGK 513
            ::.....||...|..|.|
Human   494 WVTKFIYRKIKSLWSRNK 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	GT1_Gtf-like	18..449	CDD:340817	120/457 (26%)
UGT8	NP_003351.3	Glycosyltransferase_GTB-type	21..502	CDD:471961	134/512 (26%)