DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and UGT2B17

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001068.1	Gene:	UGT2B17 / 7367	HGNCID:	12547	Length:	530	Species:	Homo sapiens

Alignment Length:	561	Identity:	153/561 - (27%)
Similarity:	270/561 - (48%)	Gaps:	94/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGYSEGA--RILAVFPLPSSSHYFFALPYLKSLASLGHEI----------------- 49
            :|||:.|...:|.|:  ::| |:| ...||:......|:.|...|||:
Human     8 VFLLMQLSCYFSSGSCGKVL-VWP-TEYSHWINMKTILEELVQRGHEVIVLTSSASILVNASKSS 70

  Fly    50 --------TSVSPYPQREPFRNIHDIPVPEVFEN-----FNEVLRIASTPRSTWQSSDFINEYVL 101
                    ||::.....:.|..:.|.....:.:|     |:::..:.      |:.||    |.:
Human    71 AIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELC------WEYSD----YNI 125

  Fly   102 NLTKTVLNNEGVRRDILGPQKPHFDLVIMDLWRMDVLSG--LAAYFDAPIIGMASYGTDWKIDEL 164
            .|.:..:.|:.:.|.:   |:..||:::.|....   .|  ||...:.|.:....:...:.:::.
Human   126 KLCEDAVLNKKLMRKL---QESKFDVLLADAVNP---CGELLAELLNIPFLYSLRFSVGYTVEKN 184

  Fly   165 MGN-VSPISYLQSPSSRFYDLEAYGER---LLHLMERTFSYMNY---KWRHVRKQETLYSQFFPS 222
            .|. :.|.||:....|...|...:.||   :::::...|.:..|   ||          .||:..
Human   185 GGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKW----------DQFYSE 239

  Fly   223 VAER-KPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGES 286
            |..| ..|.|.....::.|:..::....|||::||:..|||||. ...:.|..|::.|:|.:||:
Human   240 VLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHC-KPAKPLPKEMEEFVQSSGEN 303

  Fly   287 GVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVF-----ISKWFPQQ 346
            |::.||||:.:  .::||:...::....|.:||:::|:|:     ||.||..     :.||.||.
Human   304 GIVVFSLGSMI--SNMSEESANMIASALAQIPQKVLWRFD-----GKKPNTLGSNTRLYKWLPQN 361

  Fly   347 AILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEF 411
            .:|.||..|.||||||.....|:|:||.||:|:|...||..|:.|::..|..|.::|:.|:|.:.
Human   362 DLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDL 426

  Fly   412 RSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHS 476
            .:.:..::.:..::|.....:..:.|||:||::.|::|.|:|:.||||.|::||..:|.:::|||
Human   427 LNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHS 491

  Fly   477 LDVFGTFLVGALVILGIVTYLLVMTLRKCLF----LIKRGK 513
            |||..       .:|..|..::.|..:.|||    |.|.||
Human   492 LDVIA-------FLLACVATMIFMITKCCLFCFRKLAKTGK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	133/504 (26%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	141/529 (27%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	143/536 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150255
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8458
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690