DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and UGT2B7

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001065.2	Gene:	UGT2B7 / 7364	HGNCID:	12554	Length:	529	Species:	Homo sapiens

Alignment Length:	529	Identity:	153/529 - (28%)
Similarity:	249/529 - (47%)	Gaps:	80/529 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SHYFFALPYLKSLASLGHEIT------SVSPYPQREPFRNIHDIP---VPEVFENF--NEVLRIA 83
            ||:......|..|...|||:|      |:...|.......|...|   .....|||  .::.|.:
Human    34 SHWMNIKTILDELIQRGHEVTVLASSASILFDPNNSSALKIEIYPTSLTKTELENFIMQQIKRWS 98

  Fly    84 STPRST-W-------QSSDFINEYVLNLTKTVLNNEGVRRDILGPQKPHFDLVIMD-LWRMDVLS 139
            ..|:.| |       :......:......|.|::|:...:.:   |:..||::..| ::....|
Human    99 DLPKDTFWLYFSQVQEIMSIFGDITRKFCKDVVSNKKFMKKV---QESRFDVIFADAIFPCSEL- 159

  Fly   140 GLAAYFDAPIIGMASYGTDWKIDELMGN-VSPISYLQSPSSRFYDLEAYGERLLHLMERTFSYMN 203
             ||..|:.|.:...|:...:..::..|. :.|.||:....|...|...:.||:.:::     |:.
Human   160 -LAELFNIPFVYSLSFSPGYTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMI-----YVL 218

  Fly   204 Y-----------KWRHVRKQETLYSQFFPSVAER-KPLSEISRNFDLVLVNQHFTLGPPRPYVPN 256
            |           ||          .||:..|..| ..|||.....|:.|:...:....|.|.:||
Human   219 YFDFWFEIFDMKKW----------DQFYSEVLGRPTTLSETMGKADVWLIRNSWNFQFPYPLLPN 273

  Fly   257 MIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRI 321
            :..|||||. ...:.|..|::.|:|.:||:||:.||||:.|  .:::|:|..|:....|.:||::
Human   274 VDFVGGLHC-KPAKPLPKEMEDFVQSSGENGVVVFSLGSMV--SNMTEERANVIASALAQIPQKV 335

  Fly   322 VWKFEDELLPGKPP-----NVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPC 381
            :|:|:     |..|     |..:.||.||..:|.||..:.||||||.....|:|:||.||:|:|.
Human   336 LWRFD-----GNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPL 395

  Fly   382 LFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETA 446
            ..||..|:.|::..|..:.::...|:|.:..:.:.|::.:.|::|.....:....|||:||::.|
Human   396 FADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRA 460

  Fly   447 IWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMTLRKCLFLI-- 509
            ::|.|:|:.||||.|::||..||.:.:||||||.|..||....::.|||       :.|||..
Human   461 VFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVATVIFIVT-------KCCLFCFWK 518

  Fly   510 -----KRGK 513
                 |:||
Human   519 FARKAKKGK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	130/469 (28%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	150/525 (29%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	150/525 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150431
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8458
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690