Protein Alignment Ugt35D1 and UGT2B4

DIOPT Version :10

• Sequence 1: NP_651866.1
• Gene: Ugt35D1 / 43708
• FlyBaseID: FBgn0051002
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 161/559 - (28%)
• Similarity: 266/559 - (47%)
• Gaps: 93/559 - (16%)

  Fly     6 LLVCLLPGYSEGA--RILAVFPLPSSSHYFFALPYLKSLASLGHEIT------SVSPYPQREPFR 62
            ||:.|...:|.|:  ::| |:| ...||:......|..|...|||:|      |:|..|......
Human    10 LLIQLSCYFSSGSCGKVL-VWP-TEFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTL 72

  Fly    63 NIHDIPVPEVFENFNEVL-----RIASTPRST------------WQSSDFINEYVLNLTKTVLNN 110
            .....||......|.:::     |.|..|:.|            |..:|.:.::    .|.:::|
Human    73 KFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKF----CKDIVSN 133

  Fly   111 EGVRRDILGPQKPHFDLVIMD-LWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGN-VSPISY 173
            :.:.:.:   |:..||:|:.| ::....|  ||.....|.:....:...:.|::..|. :.|.||
Human   134 KKLMKKL---QESRFDVVLADAVFPFGEL--LAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSY 193

  Fly   174 LQSPSSRFYDLEAYGERLLHLMERTFSYMNY-----------KWRHVRKQETLYSQFFPSVAER- 226
            :....|...|...:.||:.:::     |:.|           ||          .||:..|..|
Human   194 VPVVMSELSDQMTFIERVKNMI-----YVLYFEFWFQIFDMKKW----------DQFYSEVLGRP 243

  Fly   227 KPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYF 291
            ..|||.....|:.|:..::....|.|.:||:..|||||. ...:.|..|::.|:|.:||:||:.|
Human   244 TTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHC-KPAKPLPKEMEEFVQSSGENGVVVF 307

  Fly   292 SLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPP-----NVFISKWFPQQAILAH 351
            |||:.|  .:.||:|..|:....|.:||:::|:|:     |..|     |..:.||.||..:|.|
Human   308 SLGSMV--SNTSEERANVIASALAKIPQKVLWRFD-----GNKPDTLGLNTRLYKWIPQNDLLGH 365

  Fly   352 PNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTII 416
            |..:.||||||.....|:|:||.||:|:|...||..|:.|::..|..:.|:...|:|.:..:.:.
Human   366 PKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALK 430

  Fly   417 RLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFG 481
            .::.:..::|.|...:..:.|||:||::.|::|.|:|:.||||.|::||..||.:.:||||||.|
Human   431 TVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTG 495

  Fly   482 TFLVGALVILGIVTYLLVMTLRKCLFLI-------KRGK 513
            ..|.....::.|:|        ||||.:       |:||
Human   496 FLLACVATVIFIIT--------KCLFCVWKFVRTGKKGK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	GT1_Gtf-like	18..449	CDD:340817	127/474 (27%)
UGT2B4	NP_066962.2	UDPGT	24..524	CDD:278624	153/541 (28%)